Acrichin dihydrochloride Struktur

Amodiachinhydrochlorid

Bezeichnung:Amodiachinhydrochlorid

CAS-Nr69-44-3

Englisch Name:Acrichin dihydrochloride

CBNumberCB8156037

SummenformelC20H23Cl2N3O

Molgewicht392.32

MOL-Datei69-44-3.mol

Synonyma

Amodiachinhydrochlorid

Amodiachinhydrochlorid physikalisch-chemischer Eigenschaften

storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO: 125 mg/mL (291.52 mM)
Aggregatzustand	Solid
Farbe	Light yellow to yellow

Sicherheit

WGK Germany

Gefahreninformationscode (GHS)

Acrichin dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Yellow crystalline solid; odorless; bitter. Soluble in water; sparingly soluble in alcohol; very slightly soluble in benzene, chloroform, and ether.
Originator
Camoquin HCl,Parke Davis,US,1950
Verwenden
Medicine (antimalarial).
Manufacturing Process
72.8 g (0.5 mol) of p-aminophenol hydrochloride is dissolved in 500 cc of water and added to 99 g (0.5 mol) of 4,7-dichloroquinoline. After a few minutes of warming in a steam bath, 4-(4'-hydroxyanilino)-7-chloroquinoline hydrochloride, of sufficient purity for use in further experiments, precipitates as a yellow crystalline solid. Recrystallized from methanol, the MP is over 300°C.
A mixture consisting of 13.5 g of 4-(4'-hydroxyanilino)-7-chloroquinoline hydrochloride dissolved in absolute ethanol is treated with a solution of 4.38 g of diethylamine and 1.8 g of paraformaldehyde in 20 cc of absolute ethanol. The reaction mixture is heated under reflux for 16 hours, evaporated to onehalf volume and the warm solution treated with an excess of hydrogen chloride dissolved in absolute ethanol. Acetone is added to the warm solution until it becomes turbid and then the solution is cooled. The crude dihydrochloride which separates is collected and purified by recrystallization from methanol; MP 240-242°C.
By using an equivalent amount of 4-(4'-hydroxyanilino)-7-bromoquinoline in the above procedure, 4-(3'-diethylaminomethyl-4'-hydroxyanilino)-7- bromoquinoline dihydrochloride is obtained; MP (base) 206-208°C dec.
Trademarks
Camoquin (Parke-Davis).
Therapeutic Function
Antimalarial

Acrichin dihydrochloride Upstream-Materialien And Downstream Produkte

Amodiachinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

69-44-3, Acrichin dihydrochloride Verwandte Suche:

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