Quinapril hydrochloride

Bezeichnung:Quinapril hydrochloride

CAS-Nr82586-55-8

Englisch Name:Quinapril hydrochloride

CBNumberCB8100984

SummenformelC25H31ClN2O5

Molgewicht474.98

MOL-Datei82586-55-8.mol

Quinapril hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	120-130°C
alpha	D23 +14.5° (c = 1.2 in ethanol) (Klutchko); D25 +15.4° (c = 2 in methanol) (Goel, Krolls)
storage temp.	2-8°C
Löslichkeit	H2O: >10mg/mL
Aggregatzustand	solid
Farbe	white
CAS Datenbank	82586-55-8(CAS DataBase Reference)

Sicherheit

S-Sätze:	22-24/25
WGK Germany	2
RTECS-Nr.	NW7176000
HS Code	2933492250
Giftige Stoffe Daten	82586-55-8(Hazardous Substances Data)
Toxizität	Freely sol in aq solvents. LD50 in male, female mice, rats (mg/kg): 1739, 1840, 4280, 3541 orally; 504, 523, 158, 107 i.v. (Kaplan, 1989)

Gefahreninformationscode (GHS)

Quinapril hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
Quinapril hydrochloride has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on renal tubular epithelial cell proliferation in human renal tubular epithelial cells. It has also been used as an ACE inhibitor to evaluate its effects on the expression of angiotensin II (AII) in patient-derived Atheroma samples.
Verwenden
Antihypertensive;Dopamine receptor agonist
Verwenden
Quinapril is an angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.
Definition
ChEBI: Quinapril hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of quinapril and hydrogen chloride. A prodrug for quinaprilat hydrochloride (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) for the treatment of hypertension and congestive heart failure. It has a role as an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It contains a quinapril(1+).
Trademarks
Accupril (Pfizer); Quinapril (Lupin); Quinapril (Ranbaxy) .
Allgemeine Beschreibung
Quinapril hydrochloride,(S)-[(S)-N-[(S)21-carboxy3-phenylpropyl]alanyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid 1-ethyl ester hydrochloride(Acuretic), forms the diacid quinaprilate in thebody. It is more potent than captopril and equipotent to theactive form of enalapril.
Biochem/physiol Actions
Quinapril is a short-acting angiotensin converting enzyme (ACE) inhibitor.

Quinapril hydrochloride Upstream-Materialien And Downstream Produkte

Quinapril hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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