Triprolidine hydrochloride

Bezeichnung:Triprolidine hydrochloride

CAS-Nr6138-79-0

Englisch Name:Triprolidine hydrochloride

CBNumberCB6232533

SummenformelC19H23ClN2

Molgewicht314.85

MOL-Datei6138-79-0.mol

Triprolidine hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	115-120°C
storage temp.	2-8°C
Löslichkeit	alcohol: soluble1 in 1.5 of solvent
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	>=10 g/100 mL at 20 ºC
Merck	13,9817
Stabilität	Stable, but discolours in light. Incompatible with strong oxidizing agents.
LogP	4.223 (est)
CAS Datenbank	6138-79-0(CAS DataBase Reference)
EPA chemische Informationen	Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)- (6138-79-0)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	UT7658000
HS Code	2933399090

Gefahreninformationscode (GHS)

Triprolidine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
TRIPROLIDINE HYDROCHLORIDE is a white, crystalline powder.
Verwenden
TRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet
Verwenden
anticholinergic (opthalmic)
Verwenden
trans-Triprolidine Hydrochloride is a potent H1 receptor antagonist. Anti-histamines.
Definition
TRIPROLIDINE HYDROCHLORIDE is a hydrate that is the monohydrate form of triprolidine hydrochloride. A sedating antihistamine, it is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.
Trademarks
Actidil (GlaxoSmithKline); Myidyl (USl).
Allgemeine Beschreibung
Triprolidine hydrochloride,(E)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine monohydrochloridemonohydrate (Actidil), is a white crystalline powder with a slight, but unpleasant, odor. It is soluble inwater and in alcohol, and its solutions are alkaline to litmus.
The antihistaminic activity is confined mainly to the geometricisomer in which the pyrrolidinomethyl group is transto the 2-pyridyl group. Pharmacological studies confirm thehigh activity of triprolidine and the superiority of (E) overcorresponding (Z) isomers as H1-antihistamines. At guineapig ileum sites, the affinity of triprolidine for H-receptorswas more than 1,000 times the affinity of its (Z) diasteromer.The relative potency of triprolidine is of the same orderas that of dexchlorpheniramine. The peak effect occursabout 3.5 hours after oral administration, and the duration ofeffect is about 12 hours.
Allgemeine Beschreibung
Odorless white crystalline powder. Bitter taste.
Air & Water Reaktionen
Water soluble.
Reaktivität anzeigen
Triprolidine hydrochloride discolors on exposure to light.
Health Hazard
SYMPTOMS: Symptoms of exposure to Triprolidine hydrochloride may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea.
Brandgefahr
Flash point data for Triprolidine hydrochloride are not available; however, Triprolidine hydrochloride is probably combustible.
Biologische Aktivität
Potent H 1 receptor antagonist.

Triprolidine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

6138-79-0, Triprolidine hydrochloride Verwandte Suche:

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