Povidone iodine

Bezeichnung:Povidone iodine

CAS-Nr25655-41-8

Englisch Name:Povidone iodine

CBNumberCB1121625

SummenformelC6H9I2NO

Molgewicht364.95

MOL-Datei25655-41-8.mol

Synonyma

1-Vinyl-2-pyrrolidinonpolymere, Iodkomplex

Poly(1-(2-oxo-1-pyrrolidinyl)ethylen)iodkomplex

Povidone iodine physikalisch-chemischer Eigenschaften

Schmelzpunkt	300 °C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	H2O: soluble100mg/mL
Aggregatzustand	Powder
Farbe	Yellow-brown
Geruch (Odor)	ylsh. brn. amorphous powd., sl. char. odor
Wasserlöslichkeit	Soluble in water, ethyl alcohol, isopropyl alcohol, polyethylene glycol and glycerol. Insoluble in chloroform, carbon tetrachloride, hexane, acetone and petroleum ether.
Merck	13,7784
InChI	InChI=1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)8;1-2/h2H,1,3-5H2;
InChIKey	FAAHNQAYWKTLFD-UHFFFAOYSA-N
SMILES	II.C(N1CCCC1=O)=C
CAS Datenbank	25655-41-8(CAS DataBase Reference)
EPA chemische Informationen	Povidone-iodine (25655-41-8)

Sicherheit

S-Sätze:	24/25-22
WGK Germany	2
RTECS-Nr.	TR1579600
TSCA	Yes
HS Code	29339900
Giftige Stoffe Daten	25655-41-8(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Povidone iodine Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
GELBES BIS BRAUNES HYGROSKOPISCHES PULVER.
CHEMISCHE GEFAHREN
Zersetzung beim Erhitzen unter Bildung giftiger Rauchemit Stickstoffoxiden und Iod. Schwache Säure in wässriger Lösung.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wiederholter oder andauernder Hautkontakt kann Dermatitis hervorrufen.
LECKAGE
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.
Beschreibung
Povidone iodine is iodophor, used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. A 10% povidone iodine solution contains 1% available iodine, but free-iodine is at 0.1% concentration. Skin exposure causes irritant rather than allergic contact dermatitis. In such a situation, however, iodine seems to be the true hapten.
Chemische Eigenschaften
Povidone iodine is a complex of iodine with povidone. It occurs as a yellowish brown to reddish brown amorphous powder, having a slight characteristic odour. Its solution is acid to litmus. Soluble in water and in alcohol, practically insoluble in chloroform, in carbon tetrachloride, in ether, in solvent hexane, and in acetone. It is an external antiseptic with a broad microbicidal spectrum against bacteria, fungi, viruses, protozoa, and yeasts. This gel has about 1.0% available iodine.
Originator
Betadine ,Purdue Frederick ,US ,1957
History
Povidone iodine (PI) is frequently used during surgical preparation, postoperative wound cleaning and dressing. It was described by Shelaski about seventy years ago (Shelanski and Shelanski, 1956). PI consists of the complex structure of povidone, a polymer that is structurally similar to plasma proteins, and the iodine element, which has antimicrobial properties. The function of polyvinylpyrrolidone (PVP) used as a polymer includes increasing iodine solubility and penetration, decreasing iodine ion concentration and keeping iodine bound. However, PVP does not have antimicrobial properties. Shelanski defined this complex structure as 'iodophor' (Shelanski and Shelanski, 1956).
Verwenden
Polyvinylpyrrolidone-iodine complex is used as a slow iodine release formulation that iodinates lipids and oxidizes cell compounds such as tyrosine side chains. It is utilized to study microbial decontamination of human donor eyes as well as inactivation of infectious hematopoietic necrosis virus. It is also used as a carbon nanotube coating agent to enhance water solubility. It serves as a topical antiseptic in surgery, as an aerosol for skin and mucous membrane infections and is used to prevent infection in wounds.
synthetische
Povidone Iodine Solution is an antiseptic and disinfectant agent. The preparation method of povidone iodine: be that 1.17% potassium iodide is dissolved in part water in 10% water by mass percent, 2.34% iodine is added to wherein stirring and dissolving, be mixed with iodine solution standby; 0.01% stability auxiliary agent is dissolved in part water 10% water standby; In complex reaction still, add remaining water, open and stir, dropping into 10.0% polyvinylpyrrolidone k30 dissolves, then substep adds above-mentioned two kinds of solution that prepare, finally add 7.5% solvent normal propyl alcohol, after feeding intake, allow reactant mixture at 20 ℃, react 2 hours, react complete mixture is lowered the temperature and obtained betagen solution.
Application
Povidone iodine is a broad spectrum antiseptic for topical application. It is used in first aid for minor cuts, grazes, burns, abrasions and blisters. Povidone iodine has broad applications in medicine as a surgical scrub; for pre- and post-operative skin cleansing.
Trademarks
Betadine (Alcon); E-Z Prep (Becton Dickinson Microbiology).
Therapeutic Function
Topical antiinfective
Biologische Aktivität
Povidone iodine is a microcide with broad-spectrum activity against bacteria, fungi, viruses, and protozoans. It reduces total anaerobic and aerobic bacterial counts in vitro in dog feces when applied topically as a 10% solution. Povidone iodine decreases bacterial counts and the occurrence of anastomotic leaks in a dog model of emergent resection and anastomosis of the sigmoid colon when applied in situ at a concentration of 10% v/v. Topical administration of povidone iodine (10% v/v) also reduces bacterial counts on the skin of cynomolgus monkeys. Formulations containing povidone iodine have been used to disinfect skin before and after surgery.
Veterinary Drugs and Treatments
Dilute solutions of povidone iodine (1% – 5%) have been utilized for chemical debridement of loose epithelium in canine indolent ulcers. 5% povidone iodine has also been used as an antifungal for fungal keratitis, but must be lavaged from the eye within 5 minutes to prevent damage to corneal epithelium. Generally, povidone iodine is only used once daily and then rinsed off when used in the eye as an anti-fungal. There has also been a renewed interest in utilizing povidone iodine in treating feline herpes keratitis. Solutions of commercially available 10% povidone iodine are diluted in physiologic saline to concentrations of 0.5 – 1% and applied 1 drop twice to four times daily for treatment of chronic feline herpes keratitis and may also be used prophylactically for feline herpes-virus (FHV) cats with a history of recurring ulcer.

Povidone iodine Upstream-Materialien And Downstream Produkte

Povidone iodine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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