Cytidin

Bezeichnung:Cytidin

CAS-Nr65-46-3

Englisch Name:Cytidine

CBNumberCB7854079

SummenformelC9H13N3O5

Molgewicht243.22

MOL-Datei65-46-3.mol

Synonyma

Cytidin

Cytidin physikalisch-chemischer Eigenschaften

Schmelzpunkt	210-220 °C (dec.) (lit.)
Siedepunkt	386.09°C (rough estimate)
alpha	31.5 º (c=0.6, H2O 25 ºC)
Dichte	1.3686 (rough estimate)
Brechungsindex	34 ° (C=0.7, H2O)
storage temp.	2-8°C
Löslichkeit	H₂O: 50 mg/mL
Aggregatzustand	powder
pka	4.22, 12.5(at 25℃)
Farbe	White to almost white
PH	4.13
Biologische Quelle	synthetic
Optische Rotation	[α]20/D +33°, c = 2 in H2O
Wasserlöslichkeit	SOLUBLE
Sensitive	Hygroscopic
maximale Wellenlänge (λmax)	280 (pH 1)；229.5，271 (pH 7)
Merck	14,2786
BRN	89173
Stabilität	Stable. Incompatible with strong oxidizing agents. Protect from moisture.
Kosmetik-Inhaltsstoffe Funktionen	SKIN PROTECTING SKIN CONDITIONING
InChI	1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1
InChIKey	UHDGCWIWMRVCDJ-XVFCMESISA-N
SMILES	NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
LogP	-1.808 (est)
CAS Datenbank	65-46-3(CAS DataBase Reference)
NIST chemische Informationen	Cytidine(65-46-3)
EPA chemische Informationen	Cytidine (65-46-3)

Sicherheit

R-Sätze:	68
S-Sätze:	24/25
WGK Germany	3
RTECS-Nr.	UW7370000
F	10-23
TSCA	TSCA listed
HS Code	29349990
Speicherklasse	11 - Combustible Solids
Toxizität	LD50 intraperitoneal in mouse: 2700mg/kg

Gefahreninformationscode (GHS)

Cytidine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R68:Irreversibler Schaden möglich.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Cytidine is a pyrimidine nucleoside that is composed of the pyrimidine base cytosine attached to the sugar ribose. As a constituent of RNA, cytidine pairs with guanine, and it is a precursor of uridine. Cytidine can incur several modifications in mRNA, including methylation and acetylation, that function to regulate translation. Cytidine can also be formylated to 5-formylcytidine in mitochondrial methionine transfer RNA (tRNAMet).
Chemische Eigenschaften
Cytidine is a component of RNA. It is a white water-soluble solid. which is only slightly soluble in ethanol.There are a variety of cytidine analogs with potentially useful pharmacology.
Verwenden
Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA. It was isolated from yeast nucleic acid. It can increases cell membrane phospholipids. Cytidine is used to synthesize enzyme inhibitors, antiviral agents, and anticancer agents. And also used as constituent of nucleic acids.
Application
Cytidine has been used as a non-essential aminoacid component of minimal essential medium (MEM) to analyse interspecies somatic cell nucleus transfer (iSCNT)-derived blastocysts. It has also been used as a supplement in the culture medium of HeLa cells, to study the effects of cytidine addition on rods and rings (RR) induced by glutamine deprivation.
Cytidine has been used as a component to prepare ribonucleoside stock solution to assess its effects on the anaerobic growth of several Bacillus mojavensis strains.
Definition
ChEBI: cytidine is a pyrimidine nucleoside in which cytosine is attached to ribofuranose via a beta-N(1)-glycosidic bond. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It derives from a cytosine.The derivednucleotides, cytidine mono-, di-, andtriphosphate (CMP, CDP, and CTP respectively)participate in various biochemicalreactions, notably inphospholipid synthesis.
Allgemeine Beschreibung
White crystalline powder.
Air & Water Reaktionen
Cytidine is hygroscopic. Water soluble.
Reaktivität anzeigen
Cytidine is incompatible with strong oxidizing agents. . Will react as a weak base.
Brandgefahr
Flash point data for Cytidine are not available; however, Cytidine is probably combustible.
läuterung methode
Cytidine crystallises from 90% aqueous EtOH. It has also been converted to sulfate by dissolving (~200mg) in a solution of EtOH (10mL) containing H2SO4 (50mg), whereby the salt crystallises out. It is collected, washed with EtOH and dried for 5hours at 120o/0.1mm. The sulfate has m 225o. The free base is obtained by shaking the salt solution with a weak ion-exchange resin, filtering, evaporating and recrystallising the residue from EtOH as before. [Fox & Goodman J Am Chem Soc 73 3256 1956, Fox & Shugar Biochim Biophys Acta 9 369 1952; see Prytsas & Sorm in Synthetic Procedures in Nucleic Acid Chemistry (Zorbach & Tipson Eds) Vol 1 404 1973.] [Beilstein 25 III/IV 3667.]
Einzelnachweise
[1] Nucleotide Biosynthesis Process[J]. Definitions, 2020, 30 1. DOI: 10.32388/28chil
[2] EMMANUEL MARTIN. CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation[J]. Nature, 2014, 510 7504: 288-292. DOI: 10.1038/nature13386

Cytidine Upstream-Materialien And Downstream Produkte

Cytidin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

65-46-3, Cytidine Verwandte Suche:

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