Cytidin-3'-(dihydrogenphosphat)

Bezeichnung:Cytidin-3'-(dihydrogenphosphat)

CAS-Nr63-37-6

Englisch Name:Cytidine 5’-monophosphate

CBNumberCB2700845

SummenformelC9H14N3O8P

Molgewicht323.2

MOL-Datei63-37-6.mol

Synonyma

Cytidin-3'-(dihydrogenphosphat)

Cytidin-3'-(dihydrogenphosphat) physikalisch-chemischer Eigenschaften

Schmelzpunkt	~222 °C (dec.)
Siedepunkt	678.1±65.0 °C(Predicted)
Dichte	2.15±0.1 g/cm3(Predicted)
Brechungsindex	9.8 ° (C=1, 0.5mol/L Na2HPO4)
storage temp.	2-8°C
Löslichkeit	Water (Slightly, Heated)
pka	pK2:4.39(0);pK3:6.62(+1) (25°C)
Aggregatzustand	crystalline
Farbe	White
Wasserlöslichkeit	soluble
BRN	46982
InChI	InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKey	IERHLVCPSMICTF-JDNPWWSISA-N
SMILES	P(OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](O)[C@@H]1O)(O)(O)=O
CAS Datenbank	63-37-6(CAS DataBase Reference)
EPA chemische Informationen	5'-Cytidylic acid (63-37-6)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	20/21/22-36/37/38
S-Sätze:	24/25-37/39-36-26
WGK Germany	3
RTECS-Nr.	HA3980000
F	10-21
HS Code	29349990
Toxizität	LD50 intraperitoneal in mouse: > 1gm/kg

Gefahreninformationscode (GHS)

Cytidine 5’-monophosphate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Cytidine 5'-monophosphate, also known as 5'-CMP, is a nucleotide that is used as a monomer in RNA. 5'-CMP is a key intermediate in the preparation of several nucleotide derivatives and is widely used in food and pharmaceutical industries.
Chemische Eigenschaften
white crystalline powder
Verwenden
Cytidine 5′-monophosphate has been used in Raman spectroscopy studies.
Verwenden
A constituent of nucleic acids. It was isolated from yeast nucleic acid.
Vorbereitung Methode
As a key intermediate in preparing several nucleotide derivatives, cytidine 5′-monophosphate (5′-CMP) is widely applied in food and pharmaceutical industries. Enzymatic synthesis of 5′-CMP is catalyzed by cytidine kinase (CK, EC 2.7.1.213), a type of nucleoside kinase that belongs to the PfkB family. Li et al. constructed a highly efficient biosynthesis system for manufacturing 5′-CMP in vitro. CK was used for the biotransformation of cytidine to 5′-CMP, while polyphosphate kinase (PPK) was coupled for adenosine triphosphate regeneration. Both CK and PPK were selected from extremophiles, possessing great potential for biocatalytic synthesis. After optimization, 96 mM 5′-CMP was produced within 6 h, and the yield reached nearly 100%[1].
Definition
ChEBI: A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase.
Biochem/physiol Actions
Cytidine 5′-monophosphate (CMP) is used as a substrate of uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) to form CDP which upon phosphorylation to CTP supports DNA and RNA biosynthesis.
Einzelnachweise
[1] Zonglin Li. “Efficient One-Pot Synthesis of Cytidine 5′-Monophosphate Using an Extremophilic Enzyme Cascade System.” Journal of Agricultural and Food Chemistry 68 34 (2020): 9188–9194.

Cytidine 5’-monophosphate Upstream-Materialien And Downstream Produkte

Cytidin-3'-(dihydrogenphosphat) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

63-37-6, Cytidine 5’-monophosphate Verwandte Suche:

Send Inquriy