2-Methoxy-5-sulfamoylbenzoic acid Struktur

5-Sulfamoyl-o-anissure

Bezeichnung:5-Sulfamoyl-o-anissure

CAS-Nr22117-85-7

Englisch Name:2-Methoxy-5-sulfamoylbenzoic acid

CBNumberCB7354418

SummenformelC8H9NO5S

Molgewicht231.23

MOL-Datei22117-85-7.mol

Synonyma

5-Sulfamoyl-o-anissure

5-Sulfamoyl-o-anissure physikalisch-chemischer Eigenschaften

Schmelzpunkt	220 °C
Siedepunkt	482.5±55.0 °C(Predicted)
Dichte	1.492±0.06 g/cm3(Predicted)
storage temp.	Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	3.56±0.10(Predicted)
Farbe	White to Off-White
CAS Datenbank	22117-85-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36/37/39
Hazard Note	Irritant
HS Code	2922500090

Gefahreninformationscode (GHS)

2-Methoxy-5-sulfamoylbenzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Verwenden
2-Methoxy-5-sulfamoylbenzoic Acid is a metabolite of the antipsychotic drug, Sulpiride (S689145).
synthetische
Synthesis of 2-methoxy-5-sulfamoyl benzoic Acid: In the amination reaction of 2-methoxyl-5-amino-sulfonyl benzoic acid, the main influence factors were mainly ammonia concentration, reaction temperature and reaction time. Firstly, we investigated two approaches of animation reaction: ventilation with ammonia in solvent and ammonium hydroxide as amino-reactant and solvent. In this section, the way of ventilation with ammonia in methyl alcohol and tetrahydrofuran would cause the rapid reaction, resulting to the incomplete reaction of 2-methoxy-5-sulfamoylbenzoic acid owing to the formation of 2-methoxy-5-sulfamoyl benzoic acid coated on the surface of the reaction. On the contrary, the lab test indicated that the way of ammonium hydroxide as amino-reactant and solvent can provide better experimental results. Secondly, the reactive temperature was the more important factor. The optimized amination temperature was to 30 °C. The low temperature would result to the long amination time, whereas high temperature can result to the generation of by-product owing to the hydrolysis of sulfonyl chloride. Finally, we evaluated the effect of reaction time. The optimized reaction time was to 5 hours. The extended reaction time can’t cause the significant improvement of yield. As a consequence, the best reactive temperature was to 30 °C and the best mole ratio between 2-methoxy-5-sulfonylchlorobenzoic acid and ammonium hydroxide was to 1:20 and the best reactive time was to 5 hours. Under the best conditions, the yield can reach to 75.8%.

2-Methoxy-5-sulfamoylbenzoic acid Upstream-Materialien And Downstream Produkte

5-Sulfamoyl-o-anissure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

22117-85-7, 2-Methoxy-5-sulfamoylbenzoic acid Verwandte Suche:

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