Sulpirid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H361：Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen.

• Sicherheit

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Sulpiride Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

• Chemische Eigenschaften

  Sulpiride is White Solid

• Originator

  Dogmatil,Delagrange,France,1969

• Verwenden

  dopamine receptor antagonist, antipsychotic

• Verwenden

  Sulpiride possesses moderate neuroleptic activity along with some stimulating and antidepressant effects. It has antiemetic, moderately cataleptogenic, and antiserotonin action. It facilitates increased blood flow in the stomach. It speeds up the restorative processes in tissues. It is used for schizophrenia, depression, migraines, disturbance of behavioral functions, and stomach and duodenal ulcers.

• Verwenden

  Sulpiride is an antipsychotic drug used in the treatment of Schozophrenia and depression.

• Definition

  Sulpiride is a member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.

• Manufacturing Process

  1-Ethyl-2-aminomethylpyrrolidine is reacted with 2-methoxy-5- sulfamoylbenzoic acid to give sulpiride.

• Trademarks

  Dogmatyl (Laboratoires Delagrange, France).

• Therapeutic Function

  Tranquilizer, Digestive aid

• Biologische Aktivität

  Standard D 2 -like dopamine receptor antagonist.

• Biochem/physiol Actions

  (±)-Sulpiride is a D2 dopamine antagonist and an effective treatment for schizophrenia when used in combination with clozapine, a relatively weak D2-dopaminergic antagonist. It is an antipsychotic agent and also exhibits neuroleptic properties but poorly penetrates the central nervous system.45,46

• Clinical Use

  Antipsychotic:
  Acute and chronic schizophrenia

• Synthese

  Sulpiride, N-[(1-ethyl-2-pirrolidinylmethyl]-5-sulfamoyl-O-anizamide (6.7.2), is synthesized from 5-aminosulfosalycilic acid. Methylating this with dimethylsulfate gives 2-methoxy-5-aminosulfonylbenzoic acid (6.7.1), which is transformed into an amide using 2-aminomethyl-1-ethylpyrrolidine as amine components and carbonyl-1,1??-bisimidazole as a condensing agent [70¨C74].

  

• Arzneimittelwechselwirkung

  Potentially hazardous interactions with other drugs
  Anaesthetics: enhanced hypotensive effect.
  Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedativeeffects with opioids; increased risk of ventricular arrhythmias with methadone.
  Anti-arrhythmics increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval, e.g. procainamide, disopyramide and amiodarone - avoid with amiodarone.
  Antibacterials: increased risk of ventricular arrhythmias with moxifloxacin and parenteral erythromycin - avoid with moxifloxacin.
  Antidepressants: possibly increased risk of ventricular arrhythmias and antimuscarinic side effects with tricyclics - avoid.
  Antiepileptics: antagonism (convulsive threshold lowered).
  Antimalarials: avoid with artemether/lumefantrine.
  Antipsychotics: increased risk of ventricular arrhythmias with droperidol, haloperidol and pimozide - avoid; possible increased risk of ventricular arrhythmias with risperidone.
  Antivirals: concentration possibly increased by ritonavir.
  Anxiolytics and hypnotics: increased sedative effects.
  Atomoxetine: increased risk of ventricular arrhythmias.
  Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol.
  Cytotoxics: increased risk of ventricular arrhythmias with vandetanib - avoid; increased risk of ventricular arrhythmias with arsenic trioxide.
  Diuretics: enhanced hypotensive effect.
  Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
  Pentamidine: increased risk of ventricular arrhythmias.

• Stoffwechsel

  Sulpiride undergoes little metabolism.
  95% of a dose is excreted in the urine and faeces, mainly as unchanged drug.

• Lager

  Room temperature

Sulpiride Upstream-Materialien And Downstream Produkte

Sulpirid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(299)Suppliers

15676-16-1, Sulpiride Verwandte Suche: