Indol-3-ylmethyldimethylamin

Bezeichnung:Indol-3-ylmethyldimethylamin

CAS-Nr87-52-5

Englisch Name:Gramine

CBNumberCB7342118

SummenformelC11H14N2

Molgewicht174.24

MOL-Datei87-52-5.mol

Synonyma

Indol-3-ylmethyldimethylamin

Indol-3-ylmethyldimethylamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	132-134 °C (lit.)
Siedepunkt	295.23°C (rough estimate)
Dichte	1.0715 (rough estimate)
Brechungsindex	1.5500 (estimate)
Flammpunkt	167 °C
storage temp.	Refrigerator (+4°C)
Löslichkeit	almost transparency in Methanol
Aggregatzustand	Powder
pka	17.00±0.30(Predicted)
Farbe	Beige
Wasserlöslichkeit	PRACTICALLY INSOLUBLE
Merck	14,4533
BRN	140521
LogP	2.177 (est)
CAS Datenbank	87-52-5(CAS DataBase Reference)
NIST chemische Informationen	1H-Indole-3-methanamine, N,N-dimethyl-(87-52-5)
EPA chemische Informationen	1H-Indole-3-methanamine, N,N-dimethyl- (87-52-5)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34
S-Sätze:	45-36/37/39-26
WGK Germany	3
RTECS-Nr.	NL7525000
HS Code	29339900

Gefahreninformationscode (GHS)

Gramine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
?3-(Dimethylaminomethyl)indole [87-52-5], gramine, C11H14N2, Mr 174.25, mp 138 – 139 ℃, forms colorless needles. The compound is soluble in ethanol, diethyl ether, and chloroform and insoluble in water. It can be synthesized from indole by the Mannich reaction with dimethyl-amine and formaldehyde. Gramine is used to synthesize D,L-tryptophan, the plant growth regulators indole-3-acetic acid and indole-3-butanoic acid as well as the intermediate tryptamine.
Verwenden
Reactant for preparation of:
- Dopamine D2 receptor antagonists
- Anti-malarial drugs
- 5-indolyl-Mannich bases
- Proliferation inhibitors
- Inhibitors of human mast cell chymase
- Preparation of DL-tryptophan
- Potential detoxification inhibitors of the crucifer phytoalexin brassinin
- 3-vinylindoles
- Serotonin 5-HT6 receptor ligand templates
- Selective protein kinase c delta (PKCδ) down regulators
Definition
ChEBI: Gramine is an aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3. It has a role as a plant metabolite, a serotonergic antagonist, an antiviral agent and an antibacterial agent. It is an aminoalkylindole, an indole alkaloid and a tertiary amino compound. It is a conjugate base of a gramine(1+).
Allgemeine Beschreibung
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Lager
Room temperature
läuterung methode
Crystallise gramine from diethyl ether, ethanol or acetone. It sublimes at 59o/0.001mm. The hydrochloride crystallises from EtOH/Et2O with m 190.5-191.0o(dec). [Culvenor et al. Aust J Chem 17 1301 1964, Beilstein 22 III/IV 4302, 22/10 V 25.]

Gramine Upstream-Materialien And Downstream Produkte

Indol-3-ylmethyldimethylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

87-52-5, Gramine Verwandte Suche:

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