Calciumfolinat

Bezeichnung:Calciumfolinat

CAS-Nr1492-18-8

Englisch Name:Calcium folinate

CBNumberCB7278842

SummenformelC20H25CaN7O7

Molgewicht515.54

MOL-Datei1492-18-8.mol

Synonyma

Calciumfolinat

Calciumfolinat physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300°C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	Sparingly soluble in water, practically insoluble in acetone and in ethanol (96 per cent).
Aggregatzustand	powder
Farbe	Pale Yellow to Light Yellow
Biologische Quelle	synthetic (organic)
BRN	5723924
BCS Class	1
Stabilität	Hygroscopic
InChIKey	SFFPBUMPHJUNTG-OKWBDBCSNA-N
SMILES	C(N1C(CNC2NC(N)=NC(=O)C1=2)CNC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1)=O.[Ca] \|&1:22,r\|
LogP	-3.187 (est)
CAS Datenbank	1492-18-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	36/37/38-42/43
S-Sätze:	26-36-36/37-22-45
WGK Germany	3
RTECS-Nr.	MA0600500
F	3-8-10-23
HS Code	29362900

Gefahreninformationscode (GHS)

Calcium folinate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S22:Staub nicht einatmen.
Chemische Eigenschaften
Light yellow to yellow solid
Originator
Leucovorin calcium,AstraZeneca
Verwenden
antianemic, antidote to folic acid antagonists.
Calcium folinate (folinic acid, calcium leucovorin, tetrahydrofolate) can be used in the management of methotrexate overdose and to reduce the toxicity of high-dose methotrexate chemotherapy.Calcium folinate is a reduced form of folic acid, which bypasses the inhibition of dihydrofolate reductase by methotrexate.Calcium folinate also has a role in combination with fluorouracil in the treatment of bowel cancer, where its use enhances the effect of fluorouracil by inhibition of thymidilate synthase.
Verwenden
Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
Definition
ChEBI: Calcium folinate is a tetrahydrofolic acid.
Manufacturing Process
5,10-Methenyl-5,6,7,8-tetrahydrofolic acid, chloride hydrochloride dihydrate (20 g) was added in one portion to 100 ml water at 60°C followed by N,Ndiethylethanolamine (14.9 g) which adjusted the pH to 6. The mixture was maintained at reflux for 5 hours and the pH kept between 5.7 and 6.2 by addition of N,N-diethylethanolamine. The mixture was cooled, synthetic magnesium silicate (15 g) added and slurried, and filtered through celite and diluted with 40 ml SD3A (95% ethanol with 5% methanol). The filtrate was kept at -5°C for 16 hours, aqueous calcium chloride (4.0 g) was added dropwise to the cold filtrate, and the precipitate filtered, washed with SD3A (100 ml) and with ethyl acetate (100 ml) and dried under reduced pressure.
Trademarks
Wellcovorin (GlaxoSmithKline).
Therapeutic Function
Antidote (folic acid antagonists), Antianemic
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biochem/physiol Actions
Folinic acid serves as a cofactor and participates in one-carbon-transfer reactions. It helps in improving wound healing in rats. Folinic acid plays a major role in children with autism to enhance verbal communication.
Mechanism of action
The mechanism of action of Calcium folinate against cancer is to stabilise the complex between 5-FU and thymidylate synthase, thereby enhancing the cytotoxicity of 5-FU, a pyrimidine analogue and inhibitor of thymidylate synthase, which blocks DNA production. Thymidylate synthase converts deoxyuridine monophosphate to thymine monophosphate. Administration of 5-FU reduces deoxythymidine monophosphate, preventing DNA synthesis and leading to cell death.

Calcium folinate Upstream-Materialien And Downstream Produkte

Calciumfolinat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1492-18-8, Calcium folinate Verwandte Suche:

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