4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

Bezeichnung:4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

CAS-Nr16673-34-0

Englisch Name:4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

CBNumberCB7278059

SummenformelC16H17ClN2O4S

Molgewicht368.84

MOL-Datei16673-34-0.mol

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide physikalisch-chemischer Eigenschaften

Schmelzpunkt	209-214 °C
Dichte	1.356±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	Soluble in DMSO (up to 45 mg/ml).
Aggregatzustand	Solid
pka	10.14±0.10(Predicted)
Farbe	White
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI	InChI=1S/C16H17ClN2O4S/c1-23-15-7-4-12(17)10-14(15)16(20)19-9-8-11-2-5-13(6-3-11)24(18,21)22/h2-7,10H,8-9H2,1H3,(H,19,20)(H2,18,21,22)
InChIKey	KVWWTCSJLGHLRM-UHFFFAOYSA-N
SMILES	C(NCCC1=CC=C(S(N)(=O)=O)C=C1)(=O)C1=CC(Cl)=CC=C1OC
CAS Datenbank	16673-34-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23-24-25
S-Sätze:	24/25
WGK Germany	1
HS Code	2935909550

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23:Giftig beim Einatmen.
R24:Giftig bei Berührung mit der Haut.
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
NLRP3i (16673-34-0) is an NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising?in vivo?protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1β and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2?Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2
Chemische Eigenschaften
Light Yellow Solid
Verwenden
An impurity arising in the synthesis of Glyburide (G598350).
Allgemeine Beschreibung
5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide is an organic building block. It has been reported as an intermediate in the synthesis of glyburide. Synthesis of 5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide has been reported.
Lager
Store at +4°C
Einzelnachweise
1) Fulp?et al.?(2018),?Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization; J. Med. Chem.,?61?5412 2) Marchetti?et al.?(2014),?A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse; J. Cardiovas. Pharmacol.,?63?316

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Upstream-Materialien And Downstream Produkte

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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