Ginsenoside rb1

Bezeichnung:Ginsenoside rb1

CAS-Nr41753-43-9

Englisch Name:Ginsenoside Rb1

CBNumberCB7237661

SummenformelC54H92O23

Molgewicht1109.29

MOL-Datei41753-43-9.mol

Synonyma

2-O-β-Glucopyranosyl-(3β,12β)-20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl-β-D-glucopyranosid

Ginsenoside rb1

Ginsenoside rb1 physikalisch-chemischer Eigenschaften

Schmelzpunkt	197.5°C
Siedepunkt	766.35°C (rough estimate)
Dichte	1.0971 (rough estimate)
Brechungsindex	1.6500 (estimate)
storage temp.	2-8°C
Löslichkeit	methanol: soluble9.80 - 10.20 mg/mL, clear, colorless to faintly yellow
pka	12.85±0.70(Predicted)
Farbe	Off-White to Pale Beige
Stabilität	Hygroscopic
InChIKey	GZYPWOGIYAIIPV-VOKNSFSUNA-N
LogP	2.900 (est)
CAS Datenbank	41753-43-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi,T,F
R-Sätze:	20/21/22-39/23/24/25-23/24/25-11
S-Sätze:	26-36-45-36/37-16-7
WGK Germany	3
RTECS-Nr.	LZ5856000
HS Code	29389090
Toxizität	oms-rat-ipr 50 mg/kg CPBTAL 24,2400,76

Gefahreninformationscode (GHS)

Ginsenoside Rb1 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Ginsenoside Rb1, a glycosylated PPD type ginsenoside with two sugars linked to C-3 and two sugars linked to C-20, is the major active constituent of American ginseng. Studies have demonstrated the anti-aging effects of ginsenoside Rb1 at both animal and cell levels. 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (20GPPD) is the major ingredient of ginsenoside Rb1, which has been shown to increase HAS2 expression by phosphorylating ERK and AKT signaling in human keratinocytes in a dose-dependent manner in vitro.
Verwenden
A major bioactive component of panax ginseng that promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. It has been reported to display immunostimulatory and anticancer effects.
Verwenden
Reference standard in the analysis of herbal medicinal products.
Definition
ChEBI: Ginsenoside Rb1 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group. It has a role as a neuroprotective agent, an anti-obesity agent, an anti-inflammatory drug, an apoptosis inhibitor, a radical scavenger and a plant metabolite. It is a ginsenoside, a glycoside and a tetracyclic triterpenoid. It is functionally related to a ginsenoside Rd.
benefits
Ginsenoside Rb1 (G-Rb1) is a tetracyclic triterpenoid mainly obtained from the roots or stems of Panax notoginseng and ginseng by extraction and purification. It is one of the main bioactive compounds of ginseng with minimal toxicity and neurotrophic and neuroprotective effects on brain injury. G-Rb1 promotes hippocampal nerve regeneration, enhances learning and memory, and has anti-aging and anti-fatigue effects. In addition, it activates antioxidants, stimulates the immune system, has anti-apoptotic activity, and maintains cell adenosine triphosphate (ATP) levels[1].
Allgemeine Beschreibung
Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.
Biochem/physiol Actions
Triterpene saponin found in ginseng.
Sicherheitsprofil
Poison by intravenous route. Moderately toxic by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits acrid smoke and irritating fumes.
target
p38MAPK | JNK | GLUT | Akt | IFN-γ | IL Receptor | GSK-3 | HO-1 | PKA | Estrogen receptor | Progestogen receptor
Einzelnachweise
[1] Shan Wen. “Ginsenoside Rb1 improves energy metabolism after spinal cord injury.” Neural Regeneration Research 18 6 (2023): 1332–1338.

Ginsenoside rb1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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