(3β,6α,12β)-3,12-Dihydroxydammar-24-en-6,20-diylbis[β-D-glucopyranosid]

Bezeichnung:(3β,6α,12β)-3,12-Dihydroxydammar-24-en-6,20-diylbis[β-D-glucopyranosid]

CAS-Nr22427-39-0

Englisch Name:Ginsenoside Rg1

CBNumberCB7331840

SummenformelC42H72O14

Molgewicht801.01

MOL-Datei22427-39-0.mol

Synonyma

(3β,6α,12β)-3,12-Dihydroxydammar-24-en-6,20-diylbis[β-D-glucopyranosid]

(3β,6α,12β)-3,12-Dihydroxydammar-24-en-6,20-diylbis[β-D-glucopyranosid] physikalisch-chemischer Eigenschaften

Schmelzpunkt	194～197℃
Siedepunkt	898.5±65.0 °C(Predicted)
Dichte	1.33±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly), Pyridine (Slightly)
pka	12.91±0.70(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
Stabilität	Hygroscopic
InChIKey	YURJSTAIMNSZAE-OLCOBRLXNA-N
LogP	1.670 (est)
CAS Datenbank	22427-39-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,T,F
R-Sätze:	22-39/23/24/25-23/24/25-11
S-Sätze:	2-45-36/37-16-7-24/25
WGK Germany	3
RTECS-Nr.	LY9537200
HS Code	29389090

Gefahreninformationscode (GHS)

Ginsenoside Rg1 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S2:Darf nicht in die Hände von Kindern gelangen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Ginsenoside RG1(Rg1) is a natural product found in Panax notoginseng, Panax ginseng, and Panax vietnamensis. It is one of the primary bioactive ingredients in Panax notoginseng saponins. Numerous studies have indicated that Rg1 plays significant roles in health benefits such as anticancer, neuroprotective, anti-senescence, anti-inflammation, and antioxidative effects. Also, extensive research has demonstrated that Rg1 is associated with various diseases, including cardiovascular disease, Alzheimer’s disease, spinal cord injury, and liver injury. Xue et al. and Yu et al. demonstrated that Rg1 ameliorated streptozotocin-induced oxidative stress and myocardial apoptosis and suppressed HG-induced mesenchymal activation and fibrosis[1].
Chemische Eigenschaften
White solid
Verwenden
Ginsenoside Rg1 protects against arthitis through osteoclast differentiation inhibition. Anti-tumor agent, inhibits the NF-kB-dependant MMP-expression in PMA (phorbol myristate acetate)-induced tumor cell invasion.
Definition
ChEBI: A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 <ital pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 posit on.
Einzelnachweise
[1] Hui Liu. “Ginsenoside Rg1 attenuates the inflammation and oxidative stress induced by diabetic nephropathy through regulating the PI3K/AKT/FOXO3 pathway.” Annals of translational medicine 9 24 (2021): 1789.

(3β,6α,12β)-3,12-Dihydroxydammar-24-en-6,20-diylbis[β-D-glucopyranosid] Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

22427-39-0, Ginsenoside Rg1 Verwandte Suche:

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