1,2,3-Trichlorpropan

Bezeichnung:1,2,3-Trichlorpropan

CAS-Nr96-18-4

Englisch Name:1,2,3-Trichloropropane

CBNumberCB6854719

SummenformelC3H5Cl3

Molgewicht147.43

MOL-Datei96-18-4.mol

Synonyma

1,2,3-Trichlorpropan

Glycerintrichlorhydrin

Allyltrichlorid

1,2,3-Trichlorpropan physikalisch-chemischer Eigenschaften

Schmelzpunkt	?14 °C (lit.)
Siedepunkt	156 °C (lit.)
Dichte	1.387 g/mL at 25 °C (lit.)
Dampfdruck	3.1 at 25 °C (Banerjee et al., 1990)
Brechungsindex	n20/D 1.484(lit.)
Flammpunkt	180 °F
storage temp.	2-8°C
Löslichkeit	Soluble in alcohol and ether (Weast, 1986); miscible with propyl chloride, carbon tetrachloride, and chloroform.
Farbe	Colorless to Almost colorless
Wasserlöslichkeit	2 g/L (25 ºC)
BRN	1732068
Henry's Law Constant	34.5 at 25.0 °C (mole fraction ratio-GC, Leighton and Calo, 1981)
Expositionsgrenzwerte	TLV-TWA 10 ppm (～60 mg/m³) (ACGIH), 50 ppm (MSHA, OSHA, and NIOSH); IDLH 1000 ppm (NIOSH).
Dielectric constant	2.3（29℃）
LogP	2.63 at 25℃
CAS Datenbank	96-18-4(CAS DataBase Reference)
IARC	2A (Vol. 63) 1995
NIST chemische Informationen	Propane, 1,2,3-trichloro-(96-18-4)
EPA chemische Informationen	1,2,3-Trichloropropane (96-18-4)

Sicherheit

Kennzeichnung gefährlicher	T,F,N
R-Sätze:	45-60-20/21/22-39/23/24/25-23/24/25-11-38-68/20/21/22-48/23-48/21/22-36-24/25-20
S-Sätze:	53-45-36/37-37-36-61-26-16-7
RIDADR	UN 2810 6.1/PG 3
OEB	A
OEL	TWA: 10 ppm (60 mg/m3) [skin]
WGK Germany	3
RTECS-Nr.	TZ9275000
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29031980
Giftige Stoffe Daten	96-18-4(Hazardous Substances Data)
Toxizität	Acute oral LD50 for rats 320 mg/kg (quoted, RTECS, 1985).
IDLA	100 ppm

Gefahreninformationscode (GHS)

1,2,3-Trichloropropane Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.
PHYSIKALISCHE GEFAHREN
Die Dämpfe sind schwerer als Luft.
CHEMISCHE GEFAHREN
Zersetzung beim Verbrennen unter Bildung giftiger und ätzender Rauche. Reagiert sehr heftig mit einigen Metallpulvern unter Explosionsgefahr.
ARBEITSPLATZGRENZWERTE
TLV: 10 ppm (als TWA); Hautresorption; Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
MAK: Krebserzeugend Kategorie 2; Hautresorption; (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation der Dämpfe, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C tritt langsam eine gesundheitsschädliche Kontamination der Luft ein.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen und die Atemwege. Möglich sind Auswirkungen auf Leber und Nieren mit nachfolgenden Funktionsstörungen. Exposition gegenüber hohen Konzentrationen kann zu Bewusstseinstrübung führen.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wahrscheinlich krebserzeugend für den Menschen.
LECKAGE
Persönliche Schutzausrüstung: Atemschutzfilter für organische Gase und Dämpfe. Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. NICHT in die Umwelt gelangen lassen.
R-Sätze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.
R38:Reizt die Haut.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S37:Geeignete Schutzhandschuhe tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
1,2,3-Trichloropropane is a synthetic chemical that is also known as allyl trichloride, glycerol trichlorohydrin, and trichlorohydrin. It is a colourless, heavy liquid with a sweet but strong chloroform-like odour and is combustible. It is slightly soluble in water but soluble in chloroform, diethyl ether, and ethanol. On contact with heat/ fire, It releases off irritating or toxic fumes (or gases). It evaporates very quickly and small amounts dissolve in water. It is mainly used to make other chemicals. 1,2,3-Trichloropropane was used in the past mainly as a solvent and extractive agent, including as a paint and varnish remover and as a cleaning and degreasing agent. It is now used mainly as a chemical intermediate, for example, in the production of polysulphone liquid polymers, dichloropropene and hexafluoropropylene and as a cross-linking agent in the synthesis of polysulphides.
Chemische Eigenschaften
1,2,3-Trichloropropane is a colorless liquid with a strong acid odor. slightly soluble in water; dissolves oils, fats, waxes, chlorinated rubber, and numerous resins. autoign temp 580F (304°C). Combustible.
Physikalische Eigenschaften
Clear, colorless liquid with a strong, chloroform-like odor
Verwenden
Intermediate in the manufacture of pesticides and polysulfide rubbers; formerly used as a solvent and extractive agent.
Verwenden
Paint and varnish remover, solvent, degreasing agent.
Verwenden
1,2,3-Trichloropropane is used as a solventand as an intermediate in organic synthesis.
Definition
ChEBI: 1,2,3-Trichloropropane is an organochlorine compound.
Allgemeine Beschreibung
Colorless liquid with a strong acid odor. Denser than water and slightly soluble in water. Hence sinks in water.
Reaktivität anzeigen
1,2,3-Trichloropropane is sensitive to prolonged exposure to light. Sensitive to heat. May react with active metals, strong caustics and oxidizing agents. Attacks some plastics, rubber and some coatings .
Health Hazard
Inhalation of its vapors can produce depres sion of the central nervous system, which canprogress to narcosis and convulsion as theconcentration increases. A 30-minute expo sure to a 5000-ppm concentration causedconvulsions in rats. Acute as well as chronicexposure to high concentrations can causeliver damage. 1,2,3-Trichloropropane is moretoxic than its 1,1,1-isomer. Acute oral tox icity is moderate, with LD50 values rang ing between 300 and 550 mg/kg in differentspecies of experimental animals. The liquidis a strong irritant to the eyes.
Health Hazard
Inhalation of vapor causes anesthesia, dizziness, and nausea. Vapor is highly irritating by inhalation routes and moderately irritating by dermal routes. Exposure of eyes to vapor may result in slight, transient injury to the cornea.
Brandgefahr
Combustible liquid; flash point (closed cup) 73°C (164°F), (open cup) 82°C (180°F). Vapors of 1,2,3-trichloropropane form explo sive mixtures with air, with LEL and UEL values of 3.2% and 12.6% by volume in air, respectively. The compound reacts vigorously with alkali metals, powdered magnesium, or aluminum; caustic alkalies; and oxidizers.
Flammability and Explosibility
Non flammable
Sicherheitsprofil
Confirmed carcinogen. Poison by ingestion. Moderately toxic by inhalation and skin contact. Experimental reproductive effects. A skin and severe eye irritant. Mutation data reported. Moderately flammable by heat, flames (sparks), or powerful oxidizers. See also ALLYL COMPOUNDS and CHLORINATED HYDROCARBONS, ALIPHATIC. When heated to decomposition it yields hghly toxic Cl-. To fight fre, use water (as a blanket), spray, mist, dry chemical.
mögliche Exposition
Trichloropropane dissolves oils, fats, waxes, chlorinated rubber; and numerous resins; it is used as a paint and varnish remover; a solvent; and a degreasing agent.
Carcinogenicity
1,2,3-Trichloropropane is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
Chemical/Physical. The hydrolysis rate constant for 1,2,3-trichloropropane at pH 7 and 25 °C was determined to be 1.8 x 10^-6/h, resulting in a half-life of 43.9 yr (Ellington et al., 1988). The hydrolysis half-lives decrease at varying pHs and temperature. At 87 °C, the hydrolysis half-lives at pH values of 3.07, 7.12, and 9.71 were 21.1, 11.6, and 0.03 d, respectively (Ellington et al., 1986). By analogy to 1,2-dibromo-2-chloropropane, the following hydrolysis products would be formed: 2,3-dichloro-1-propanol, 2,3-dichloropropene, epichlorohydrin, 1-chloro-2,3- dihydroxypropane, glycerol, 1-hydroxy-2,3-propylene oxide, 2-chloro-3-hydroxypropene, and HCl (Kollig, 1993).
The volatilization half-life of 1,2,3-trichloropropane (1 mg/L) from water at 25 °C using a shallow-pitch propeller stirrer at 200 rpm at an average depth of 6.5 cm was 56.1 min (Dilling, 1977).
Versand/Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Toxicity evaluation
It is currently believed that TCP itself has very low activity, while its metabolites mainly cause toxicity, carcinogenicity, and other effects. The liver can metabolize TCP by cytochrome P450 enzymes to give reactive intermediates, which bind to glutathione or other protein for excretion. The reactive intermediates can bind to DNA, proteins, and other molecules and cause hepatocellular damage, gene mutation, and organ dysfunction. Activation of the molecule may occur by reaction with glutathione. The metabolites (e.g., dichloroacetone) accumulated through glutathione depletion and consequently covalent binding to DNA and other macromolecules such as microsomal proteins.
Inkompatibilitäten
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Violent decomposition with chemically active metals; strong bases. Keep away from chlorinated rubber, resins and waxes; and sunlight.
Waste disposal
Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.

1,2,3-Trichloropropane Upstream-Materialien And Downstream Produkte

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