4-Chloro-2-(methylsulfonyl)pyrimidine

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

4-Chloro-2-(methylsulfonyl)pyrimidine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  White solid

• Synthese

  

  49844-90-8

  

  97229-11-3

  General procedure for the synthesis of 4-chloro-2-(methylsulfonyl)pyrimidine from 2-methylthio-4-chloropyrimidine: 2-methylthio-4-chloropyrimidine (7.25 mL, 62.3 mmol) and 95% ethanol (100 mL) were added to a 250-mL single-necked flask, and the mixture was cooled to 0 °C under magnetic stirring. 30% hydrogen peroxide (14.4 mL, 187 mmol) and ammonium molybdate tetrahydrate (2.18 g, 1.87 mmol) were slowly added dropwise. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and stirred overnight under nitrogen protection. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure, followed by evaporation with the addition of water (200 mL). The resulting product was dried with anhydrous sodium sulfate, filtered and concentrated, and finally purified by silica gel column chromatography to give 10.2 g of white solid product in 85.7% yield.

• Einzelnachweise

  [1] Organic Letters, 2011, vol. 13, # 19, p. 5000 - 5003
  [2] Journal of Organic Chemistry, 2003, vol. 68, # 13, p. 5388 - 5391
  [3] Patent: CN108947974, 2018, A. Location in patent: Paragraph 0122; 0125; 0127-0129
  [4] Heterocycles, 1985, vol. 23, # 3, p. 611 - 616
  [5] Journal of Medicinal Chemistry, 2007, vol. 50, # 6, p. 1146 - 1157

4-Chloro-2-(methylsulfonyl)pyrimidine Upstream-Materialien And Downstream Produkte

4-Chloro-2-(methylsulfonyl)pyrimidine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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