Sulfamethoxazol

Bezeichnung:Sulfamethoxazol

CAS-Nr723-46-6

Englisch Name:Sulfamethoxazole

CBNumberCB6473303

SummenformelC10H11N3O3S

Molgewicht253.28

MOL-Datei723-46-6.mol

Synonyma

Sulfamethoxazol

Sulfamethoxazol physikalisch-chemischer Eigenschaften

Schmelzpunkt	166 °C
Siedepunkt	482℃
Dichte	1.3915 (rough estimate)
Brechungsindex	1.6630 (estimate)
Flammpunkt	>110°(230°F)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	Practically insoluble in water, freely soluble in acetone, sparingly soluble in ethanol (96 per cent). It dissolves in dilute solutions of sodium hydroxide and in dilute acids.
pka	pKa 5.60±0.05 (Uncertain)
Farbe	White to Pale Yellow
Wasserlöslichkeit	Soluble in ethanol or acetone. Very slightly soluble in water
Sensitive	Light Sensitive
Merck	14,8918
BRN	6732984
BCS Class	2,4
Stabilität	Stable, but light sensitive. Incompatible with strong oxidizing agents.
InChIKey	JLKIGFTWXXRPMT-UHFFFAOYSA-N
CAS Datenbank	723-46-6(CAS DataBase Reference)
IARC	3 (Vol. Sup 7, 79) 2001
NIST chemische Informationen	Sulfanilamide, n1-(5-methyl-3-isoxazolyl)-(723-46-6)
EPA chemische Informationen	Sulfamethoxazole (723-46-6)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-43-22
S-Sätze:	26-36-36/37/39-22
WGK Germany	2
RTECS-Nr.	WP0700000
TSCA	Yes
HazardClass	IRRITANT
HS Code	29350090
Giftige Stoffe Daten	723-46-6(Hazardous Substances Data)
Toxizität	LD50 orally in mice: 3662 mg/kg (Yamamoto)

Gefahreninformationscode (GHS)

Sulfamethoxazole Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R43:Sensibilisierung durch Hautkontakt möglich.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Beschreibung
Like sulfisoxazole, this drug is effective in treating infections caused by streptococci, gonococci, pneumococci, staphylococci as well as colon bacillus. Unlike sulfisoxazole, only about 70% of it binds with proteins in the plasma after oral administration, and it diffuses mostly to tissues and tissue fluids. However, since it is removed much slower than sulfisoxazole, it does not require frequent administration and is also the drug of choice for many systemic infections. Moreover, it is an ingredient of a combined drug named bactrim, biseptol, and so on (which will be examined later on), which has a fixed correlation with trimethoprim. Synonyms of this drug are gantanol, sinomin, sulfisomezole, and others.
Chemische Eigenschaften
solid
Verwenden
An antibacterial drug. Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.This compound is a contaminant of emerging concern (CECs).
Verwenden
antibacterial, antipneumocystis
Definition
ChEBI: An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.
Trademarks
Gantanol (Roche); Urobak (Shionogi).
Antimicrobial activity
The intrinsic activity is similar to that of sulfadiazine.
Allgemeine Beschreibung
Sulfamethoxazole’s plasma half-life is 11 hours. Sulfamethoxazole is a sulfonamide drug closely relatedto sulfisoxazole in chemical structure and antimicrobial activity.It occurs as a tasteless, odorless, almost white crystallinepowder. The solubility of sulfamethoxazole in the pHrange of 5.5 to 7.4 is slightly lower than that of sulfisoxazole but higher than that of sulfadiazine, sulfamerazine, or sulfamethazine.Following oral administration, sulfamethoxazole is notabsorbed as completely or as rapidly as sulfisoxazole, andits peak blood level is only about 50% as high.
Allgemeine Beschreibung
Crystals or white powder.
Air & Water Reaktionen
Insoluble in water.
Brandgefahr
Flash point data for Sulfamethoxazole are not available but Sulfamethoxazole is probably non-flammable.
Pharmazeutische Anwendungen
This is the sulfonamide component of co-trimoxazole. It is slightly soluble in water.
Pharmakokinetik
Oral absorption： 85%
C_max 800 mg oral： c.50 mg/L after 3–6 h
Plasma half-life： 6–20 h
Volume of distribution： 12–18 L
Plasma protein binding： 65%
Penetration of extravascular sites, including the CSF, is good. It crosses the placenta and achieves levels in breast milk of about 10% of the simultaneous plasma concentration. It is extensively metabolized, but about 30% of the dose is excreted unchanged in urine so that high concentrations are achieved.
Clinical Use
Sulfamethoxazole is used only in combination with the diaminopyrimidine trimethoprim.
Nebenwirkungen
Unwanted effects are those common to sulfonamides. In addition, benign intracranial hypertension has been reported in children. Most side effects of co-trimoxazole are thought to be attributable to the sulfonamide component.
Sicherheitsprofil
Moderately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Synthese
Sulfamethoxazole, N1 -(5-methyl-3-isoxazolyl)sulfanilamide (33.1.20), is synthesized by a completely analogous scheme, except by using 3-amino-5-methylisoxazol as the heterocyclic component.

Sulfamethoxazole Upstream-Materialien And Downstream Produkte

Sulfamethoxazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

723-46-6, Sulfamethoxazole Verwandte Suche:

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