2-Amino-4-bromopyridine

Bezeichnung:2-Amino-4-bromopyridine

CAS-Nr84249-14-9

Englisch Name:2-Amino-4-bromopyridine

CBNumberCB6337719

SummenformelC5H5BrN2

Molgewicht173.01

MOL-Datei84249-14-9.mol

2-Amino-4-bromopyridine physikalisch-chemischer Eigenschaften

Schmelzpunkt	142-146 °C
Siedepunkt	268.2±20.0 °C(Predicted)
Dichte	1.710±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	5.72±0.11(Predicted)
Farbe	Off-White to Beige
InChI	InChI=1S/C5H5BrN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)
InChIKey	BAQKUNMKVAPWGU-UHFFFAOYSA-N
SMILES	C1(N)=NC=CC(Br)=C1
CAS Datenbank	84249-14-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-36-22
S-Sätze:	26-36
WGK Germany	3
HazardClass	IRRITANT
HS Code	29333990
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2

Gefahreninformationscode (GHS)

2-Amino-4-bromopyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Off-White to Beige Solid
Verwenden
2-Amino-4-bromopyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Synthese

207799-10-8

84249-14-9

General procedure for the synthesis of 2-amino-4-bromopyridine from 2-Boc amine-4-bromopyridine: 2-Boc amine-4-bromopyridine (200 mg, 0.73 mmol) was suspended in water (1 mL) and hydrobromic acid (1 mL, 48 wt% aqueous solution) was added. The reaction mixture was stirred at room temperature for 16 h before being poured into aqueous sodium bicarbonate (25 mL) and extracted with ethyl acetate (3 x 25 mL). The organic phases were combined, dried over magnesium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (pure ethyl acetate as eluent) to give 2-amino-4-bromopyridine. Yield: 73 mg (58%). LC/MS retention time: 0.69 min. m/z by mass spectrometry (electrospray positive ion mode): 175, 173 [M+H]+.
Einzelnachweise
[1] Patent: WO2008/57497, 2008, A2. Location in patent: Page/Page column 301
[2] Patent: WO2007/89669, 2007, A2. Location in patent: Page/Page column 212-213
[3] Patent: WO2008/57469, 2008, A1. Location in patent: Page/Page column 301
[4] Patent: WO2008/57468, 2008, A1. Location in patent: Page/Page column 301
[5] Australian Journal of Chemistry, 1982, vol. 35, # 10, p. 2025 - 2034

2-Amino-4-bromopyridine Upstream-Materialien And Downstream Produkte

2-Amino-4-bromopyridine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

84249-14-9, 2-Amino-4-bromopyridine Verwandte Suche:

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