Pyridin-2,6-diyldimethanol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H318：Verursacht schwere Augenschäden.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2,6-Pyridinedimethanol Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R37/38:Reizt die Atmungsorgane und die Haut.
  R41:Gefahr ernster Augenschäden.
  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S39:Schutzbrille/Gesichtsschutz tragen.
  S24/25:Berührung mit den Augen und der Haut vermeiden.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

• Chemische Eigenschaften

  light yellow to beige crystalline powder

• Verwenden

  2,6-Pyridinedimethanol can be used as a quantum dot solution for photoelectric device and biomedicine and also a ligand to synthesize a variety of metal complexes and catalysts.

• synthetische

  The preparation of 2,6-Pyridinedimethanol is as follows:2640g of 2,6-dibromomethylpyridine, 3L of 30% aqueous sodium hydroxide solution, and 10L of ethanol were placed in a 20L reaction flask. Turn on the agitation. The reaction solution was heated to reflux and the reaction was kept for 5h. The TLC to intermediate state reaction is complete. The reaction solution is cooled to room temperature, plus into 20L of ice water, stir for 20min. The aqueous phase was extracted twice with 10L of dichloromethane and the organic phases were combined. The organic phase is concentrated under reduced pressure to dry, a solid of 1232g was obtained, the yield was 88.6%, and the liquid phase was 98%.

  

• Synthese

  

  5453-67-8

  

  1195-59-1

  General procedure for the synthesis of 2,6-pyridinedimethanol from dimethyl pyridine-2,6-dicarboxylate: dimethyl pyridine-2,6-dicarboxylate (9.75 g, 50 mmol) was dissolved in 40 mL of anhydrous ethanol and stirred under ice-bath conditions. Sodium borohydride (7.8 g, 4 eq.) was added in batches over 15 min and the reaction mixture was kept stirring at 0°C for 1 hr. The ice bath was then removed and the reaction mixture was allowed to continue stirring at room temperature for 2 hours. Next, the reaction mixture was placed on a steam bath and heated to reflux for 10 hours. Upon completion of the reaction, the solvent was removed by vacuum distillation. The residue was mixed with 40 mL of acetone and heated on a steam bath for 1 hour, after which the solvent was again removed by vacuum distillation. The resulting residue was mixed with 40 mL of aqueous potassium carbonate and heated on a steam bath for 1 hour, after which the solvent was removed by vacuum distillation. The final residue was dissolved in 100 mL of water and the aqueous solution was continuously extracted with chloroform for 10 h. The final 2,6-pyridinedimethanol was obtained as 6 g (87% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.70 (t, J=7.6 Hz, 1H), 7.20 (d, J=7.7 Hz, 2H), 4.78 (s, 4H).

• Einzelnachweise

  [1] Organic Letters, 2010, vol. 12, # 11, p. 2532 - 2535
  [2] Heterocycles, 2015, vol. 90, # 1, p. 625 - 630
  [3] Tetrahedron Letters, 2013, vol. 54, # 43, p. 5771 - 5774
  [4] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2009, vol. 72, # 1, p. 198 - 203
  [5] Organic and Biomolecular Chemistry, 2017, vol. 15, # 46, p. 9923 - 9931

2,6-Pyridinedimethanol Upstream-Materialien And Downstream Produkte

Pyridin-2,6-diyldimethanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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