2-Pyridylmethanol

Bezeichnung:2-Pyridylmethanol

Englisch Name:2-(Hydroxymethyl)pyridine

CBNumberCB3222786

SummenformelC6H7NO

Molgewicht109.13

Synonyma

2-Pyridylmethanol

2-Pyridylmethanol physikalisch-chemischer Eigenschaften

Schmelzpunkt	5 °C
Siedepunkt	112-113 °C/16 mmHg (lit.)
Dichte	1.131 g/mL at 25 °C (lit.)
Dampfdruck	3.47Pa at 25℃
Brechungsindex	n20/D 1.543(lit.)
Flammpunkt	>230 °F
storage temp.	2-8°C
Löslichkeit	miscible
Aggregatzustand	Liquid
pka	13.48±0.10(Predicted)
Farbe	Clear colorless to yellow or brown
Wichte	1.131
PH	6-8 (100g/l, H2O, 20℃)
Geruch (Odor)	pyridine odor
Wasserlöslichkeit	miscible
Sensitive	Hygroscopic
BRN	107849
InChIKey	SHNUBALDGXWUJI-UHFFFAOYSA-N
LogP	0.11
CAS Datenbank	586-98-1(CAS DataBase Reference)
NIST chemische Informationen	Piconol(586-98-1)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-22
S-Sätze:	26-36-37/39
WGK Germany	3
RTECS-Nr.	UT4689000
F	3-8
Hazard Note	Irritant/Keep Cold/Hygroscopic
HazardClass	IRRITANT, HYGROSCOPIC, KEEP COLD
HS Code	29333999

Gefahreninformationscode (GHS)

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
CLEAR COLORLESS TO YELLOW OR BROWN LIQUID
Verwenden
2-Pyridinemethanol is used as a pyridylalcohol with hypoglycemic activity.
Verwenden
A pyridylalcohol with hypoglycemic activity and potential apoptotic effect in human leukemia cells.
Verwenden
decongestant
synthetische
The preparation of 2-(Hydroxymethyl)pyridine is as follows:NaOH (0.5 g, 12.5 mmol), Al2O3 (2.0 g, 19.6 mmol), aldehyde 1f-g (2 mmol) and H2O (400 μL) were grinded in a mortar. Next, the paste were placed in a glass 10 mL pressure vials and reaction was carried out in microwave reactor: standard mode (200 W), 100 °C, 2 min. After that, reaction mixture was extracted with DCM (2 × 20 mL). Organic layer was evaporated under reduce pressure yielding 2f-g. Solid residue was washed by water (2 × 15 mL). Aqueous phase was acidify with 1N HCl to pH 5.5 and centrifuged. After that aqueous layer was pour down and precipitate was lyophilisated. Products 3f-g were obtained as white solids.
Definition
ChEBI: 2-Pyridinylmethanol is a member of pyridines.