Endosulfan (ISO)

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P262：Nicht in die Augen, auf die Haut oder auf die Kleidung gelangen lassen.

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Thiosulfan Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  REIN: FARBLOSE KRISTALLE; TECHNISCH: BRAUNE FLOCKEN MIT CHARAKTERISTISCHEM GERUCH.

• CHEMISCHE GEFAHREN

  Zersetzung beim Erhitzen unter Bildung giftiger Rauche mit Schwefeloxiden und Chlor. Reagiert mit Basen unter Vergiftungsgefahr (Schwefeldioxidrauche). Greift Eisen an.

• ARBEITSPLATZGRENZWERTE

  TLV: mg/m?(als TWA) Hautresorption Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
  MAK nicht festgelegt (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Versprühen oder Dispergieren schnell erreicht werden, vor allem als Pulver.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Möglich sind Auswirkungen auf Zentralnervensystem und Blut mit nachfolgender Reizbarkeit, Krämpfen und Nierenversagen. Exposition in hohen Konzentrationen kann zum Tod führen. Die Auswirkungen treten u.U. verzögert ein. ärztliche Beobachtung notwendig.

• LECKAGE

  NICHT in die Kanalisation spülen. Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.

• R-Sätze Betriebsanweisung:

  R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.
  R36:Reizt die Augen.
  R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
  R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
  R65:Gesundheitsschädlich: kann beim Verschlucken Lungenschäden verursachen.
  R62:Kann möglicherweise die Fortpflanzungsfähigkeit beeinträchtigen.
  R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
  R48/20:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Einatmen.
  R38:Reizt die Haut.
  R11:Leichtentzündlich.

• S-Sätze Betriebsanweisung:

  S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  S62:Bei Verschlucken kein Erbrechen herbeiführen. Sofort ärztlichen Rat einholen und Verpackung oder dieses Etikett vorzeigen.

• Beschreibung

  Endosulfan (70) [115-29-7], 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3,- benzo-dioxathiepine 3-oxide (IUPAC) [The technical product is a mixture of two isomers: α-endosulfan: 3α,5αβ,6α, 9α,9αβ (64–67%) (70a) and β-endosulfan 3α,5aα,6β,9β, 9aα, (29–32%) (70b)]; [959-98-8] (formerly [33213-66- 0]) (β-endosulfan);[33213-65-9] (formerly [891-86-1] and [19670-15-6]) (β-endosulfan) is the adduct of hexachlorocyclopentadiene and 1,4-dihydroxy-2-butene reacted further with SOCl2 to produce 6,7,8,9,10,10-hexachloro- 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxa thiepin-3-oxide. The technical product is a brownish solid, mp 70–100 ?C, vapor pressure 1.3 mPa at 25 ?C, soluble in petroleum solvents but having low solubility in water. It consists of about four parts of α-isomer (mp 108 ?C, cis with regard to the sulfite group) and one part of the β-isomer (mp 206 ?C, trans with regard to the sulfite group). The α-isomer, which is somewhat more insecticidal, is slowly converted to the more stable β-isomer at high temperature, and both isomers are oxidized slowly to endosulfan sulfate [1031-07-8] (mp 181 ?C). In acid media, both isomers form endosulfan diol [2157-19-9] (mp 203 ?C).

• Chemische Eigenschaften

  (commercial product): Brown crystals. Mixture of two isomers.

• Chemische Eigenschaften

  Endosulfan is a chlorinated cyclodiene insecticide. The pure product is a colorless crystalline solid. The technical product is a light to dark brown waxy solid. It has a rotten egg or sulfur odor.

• Chemische Eigenschaften

  Endosulfan is a pesticide. It is a creamto brown-colored solid that may appear in the form of crystals or fl akes. It has a smell like turpentine, but does not burn. It does not occur naturally in the environment. Endosulfan is used to control insects on food and non-food crops and also as a wood preservative. Endosulfan is used for the control of ticks and mites, and the control of rice stem borers. It is an RUP, meaning it can only be used by professional applicators. Endosulfan, commonly known by its trade name Thiodan, is an insecticide and was fi rst introduced in the 1950s. Endosulfan enters the air, water, and soil during its manufacture and use. It is often sprayed onto crops and the spray may travel long distances before it lands on crops, soil, or water. On crops, endosulfan usually breaks down in a few weeks, but it sticks to soil particles and may take years to completely break down. Endosulfan does not dissolve easily in water. In surface water, endosulfan attaches to soil particles fl oating in water or attaches to soil at the bottom. It can build up in the bodies of animals that live in endosulfan- contaminated water. It is also extremely toxic to fi sh and other aquatic life. Exposures to endosulfan occur among workers and people working in industries involved in making endosulfan or as pesticide applicators and by skin contact with soil containing endosulfan.

• Verwenden

  Endosulfan is used for the control of sucking, chewing, boring insects and mites on a wide variety of crops. It also controls tsetse flies.

• Verwenden

  Insecticide.

• Definition

  ChEBI: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.

• Allgemeine Beschreibung

  Endosulfan is a pesticide. It is a cream- to brown-coloured solid that may appear in the form of crystals or flakes. It has a smell like turpentine, but does not burn. It does not occur naturally in the environment. It is a restricted use pesticide, meaning that it can only be used by professional applicators.

• Air & Water Reaktionen

  Sightly soluble in water. Slowly hydrolyzes to form sulfur dioxide and a diol; hydrolyzes more rapidly under basic or acidic conditions.

• Reaktivität anzeigen

  Thiosulfan is an organochlorine, cyclodiene derivative. Thiosulfan is also a sulfite ester. Halogenated aliphatic or cyclic alkane compounds are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. As Thiosulfan is rather highly substituted Thiosulfan may be resistant to reaction. However, materials in this group are incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. As an ester, Thiosulfan will hydrolyze to form sulfur dioxide and diol; reaction is more rapid under basic conditions.

• Hazard

  Toxic by ingestion, inhalation, and skin absorption; use may be restricted. Lower respiratory tract irritant; liver and kidney damage. Questionable carcinogen.

• Health Hazard

  Thiosulfan is very toxic. The probable oral lethal dose is 50 to 500 mg/kg, or 1 teaspoonful to 1 ounce for a 150 lb. person.

• Health Hazard

  Endosulfan is readily absorbed by the stomach, the lungs, and through the skin, meaning that all routes of exposure can pose a hazard. Exposures to endosulfan cause adverse health effects and poisoning. The symptoms of toxicity include, but are not limited to, hyperactivity, nausea, dizziness, headache, irritability, restlessness, muscular twitching, and convulsions have been observed in adults exposed to high doses. Severe exposures cause poisoning, disturbances of the CNS, and may result in death. Laboratory studies in experimental animals indicated that long-term exposure to endosulfan can also damage the kidneys, testes, and liver and may possibly affect the body’s ability to fi ght infection. More studies are needed to confi rm similar situations in humans. Reports have indicated that the most prominent signs of acute exposure are hyperactivity, tremors, decreased respiration, diffi culty in breathing, salivation, and convulsions. Long-term neurotoxic effects have been observed after high acute exposure. The National Poison Control Information Center of the Philippines recorded 278 poisonings, including 85 deaths due to endosulfan in 1990. In Colombia, in 1993, at least 60 people were poisoned and one person died as a result of exposure to thiodan.

• Health Hazard

  Highly toxic; exhibits acute, delayed,and chronic toxicity; symptoms includenausea, vomiting, weakness, somnolence,excitement, and muscle contraction; causesdermatitis and irritation on skin contact; astimulant to central nervous system, producing convulsions; can cause adverse reproductive effects; no evidence of carcinogenicityin rats and mice; oral LD50 value (mice):～7.5 mg/kg; exposure limit: PEL/TLV-TWA(skin) 0.1 mg/m³ (OSHA:ACGIH); RCRAWaste Number P050; US EPA listedextremely hazardous substance.
  Oktay et al. (2003) have reported a case ofendosulfan poisoning associated with neurological symptoms in two patients after eatingcontaminated food in Turkey.

• Brandgefahr

  Container may explode in heat of fire. Fire or run off from fire control water may release irritating or poisonous gases. Slowly oxidizes in air. Do not store at temperature below 20F.

• Landwirtschaftliche Anwendung

  Insecticide, Acaricide: A U.S. EPA restricted Use Pesticide (RUP). Not approved for use in EU countries. Globally banned as of April 29, 2010. Endosulfan was added to the list of Stockholm Convention Persistent Organic Pollutants (POPs): Annex A (Elimination). Endosulfan is a chlorinated hydrocarbon insecticide and acaricide of the cyclodiene subgroup which acts as a poison to a wide variety of insects and mites on contact. Although it may also be used as a wood preservative, it is used primarily on a wide variety of food crops including tea, coffee, fruits, and vegetables, as well as on rice, cereals, maize, sorghum, or other grains. Formulations of endosulfan include emsulsifiable concentrate, wettable powder, ultra-low volume (ULV) liquid, and smoke tablets. It is compatible with many other pesticides and may be found in formulations with dimethoate, malathion, methomyl, monocrotophos, pirimicarb, triazophos, fenoprop, parathion, petroleum oils, and oxine-copper. It is not compatible with alkaline materials. Technical endosulfan is made up of a mixture of two molecular forms (isomers) of endosulfan, the alpha-and beta-isomers.

• Handelsname

  AFIDEN®; BEOSIT®; BIO 5,462®; CHLORTHIEPIN®; CLEAN-CROP®; CRISUFAN®; CYCLODAN®; DE-PESTER®; DESTROY®; DEVISULPHAN®; DISSULFAN CE®; ENDOCEL® ENDOCIDE®; ENDOSOL®; END-O-SULFAN®; ENDOTAF®; ENDOX®; ENSURE®; E-Z FLO®; FMC 5462®; HEXASULFAN®; HILDAN®; HOE 2671®; INSECTO®; INSECTOPHENE®; KENDAN®; KERNTOX®; KOP-THIODAN®; MALIX®; MALUX; MAUX®; MOS-570; METHOFAN®; NCI-C00566; NIA 5462®, NIAGARA 5,462; NIAGARA 5,462®[C]; PHASER®; RASAYANSULFAN; ROCKY®; THIFOR®; THIDAN®; THIMUL®; THIODAN®; α-THIODAN®; β-THIODAN®; THIONEX; α-THIONEX®; β-THIONEX®; THIOKILL®; THIOFOR®; THIONEX®; THIOSULFAN®; THIOSULFAN THIONEL®; THISULFAN TIOVEL; TIONEL; TIOVEL®

• Pharmakologie

  The rat LD₅₀ values are 43, 18 mg/kg (oral) and 130, 74 mg/kg (dermal). The α-isomer has somewhat greater insecticidal activity and is slowly converted to the more stable β-isomer at a high temperature. Both isomers oxidize slowly in air and in biological systems to endosulfan sulfate [1031-07-8], mp 181–182 ?C. In acid media, both isomers form endosulfan diol [2157-19-9], mp 203–205 ?C.
  Endosulfan is a broad-spectrum insecticide used to control pests of vegetables, fruit, field crops, and ornamentals. Unlike other cyclodiene insecticides, it is biodegradable by hydrolysis at the sulfite ester bonds and is more readily metabolized. It is also less persistent on plant surfaces, and 50% of the residues are lost in 3–7 days. Volatilization may be the major route of loss.
  Endosulfan is readily hydrolyzed in water to the diol (74), but it is moderately persistent in soil. Endosulfan (α- and β-endosulfan) is degraded in soil with DT₅₀ 30 to 70 days. The major metabolite is usually endosulfan sulfate (71), which is degraded more slowly. In the field DT₅₀ for total endosulfan (α- and β-endosulfan and endosulfan sulfate) is 5 to 8 months.

• Sicherheitsprofil

  Poison by ingestion, inhalation, skin contact, intraperitoneal, and subcutaneous routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic and neoplastigenic data. Human systemic effects: convulsions, cyanosis. Human mutation data reported. A central nervous system stimulant producing convulsions. A htghly toxic organochlorine pesticide that does not accumulate significantly in human tissue. Absorption is normally slow, but is increased by alcohols, oil, and emulsifiers. When heated to decomposition it emits toxic fumes of Cl and SOx. See also CHLORIDES and SULFITES

• mögliche Exposition

  Those engaged in the manufacture, formulation, and application of this material

• Erste Hilfe

  If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Speed in removing material from skinis of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If this chemicalhas been inhaled, remove from exposure, begin rescuebreathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart actionhas stopped. Transfer promptly to a medical facility. Whenthis chemical has been swallowed, get medical attention.Consult hospital or poison control center on use of antidotes.Transport to health-care facility.

• Carcinogenicity

  Equivocal results have been found in genotoxic assays, but endosulfan was mutagenic and clastogenic and induced effects on cell cycle kinetics in various in vivo and in vitro tests.
  In reproductive studies, male rats treated at 3.0 mg/kg from day 15 to 21 of gestation had reduced sperm production in adulthood.
  The 2003 ACGIH threshold limit value-time-weighted average (TLV-TWA) is 0.1mg/m3 with a notation for skin absorption.

• Stoffwechselwegen

  When endosulfan is incubated with microorganisms, endosulfan is extensively degraded in nitrogen- deficient, carbon-deficient, and nitrogen-rich cultures of Phanerochaete chrysosporium and is primarily oxidized to endosulfan sulfate, which is a terminal end product, or hydrolyzed to the non-sulfur-containing metabolites. An initial hydrolysis of endosulfan results in the formation of the intermediate metabolite or endosulfan diol, which further undergoes oxidation to yield endosulfan hydroxyether followed by the formation of endosulfan lactone or tentatively identified endosulfan dialdehyde.

• Stoffwechsel

  Endosulfan is metabolized rapidly inmammalian organisms to less toxic metabolites and to polar conjugates. The sulfate is also a majormetabolite in plants and occurs as a metabolite in some mammals. Endosulfan is quite toxic to water organisms, and residues were found in runoff water, sediment, infiltration water, and soil following a single application.
  Rats dosed orally or intraperitoneally with endosulfan (4–8 mg/Kg) excreted unchanged endosulfan, the hydroxy ether (72), the lactone (73), and unidentified metabolites in urine in the ratio 3 : 1 : 1 : 2. The diol, the hydroxy ether, and the lactone were identified in most samples of urine and feces. The metabolite most frequently recovered from tissues, organs, and feces was endosulfan sulfate .
  Transient amounts of endosulfanand endosulfan sulfate were detected in the body fat and liver of mice after they were dosed with 14C labeled endosulfan. The mice excreted endosulfan metabolites. Cows fed 2.5–5 ppm endosulfan for 30 days excreted 0.1–0.2 ppm endosulfan sulfate in milk.
  After a single dose of 14 mg/kg of 14C endosulfan, sheep excreted 0.25 ppm in milk in the 6–24-h period following ingestion (102). Residues fell to 0.04 ppm and 0.01 ppm after 3 and 11 days, respectively. The main metabolites in urine were the diol and the hydroxy ether.
  Endosulfan sulfate, the ether, the hydroxy ether, the lactone, and one unidentified metabolite were detected on the surface when male migratory locusts (Pachytilus migratoides) were exposed to endosulfan by oral, cutaneous, or subcutaneous administration. Similarmetabolic pathways were observed in the housefly and the cockroach. Six to seven days after the last dose, neither endosulfan nor its metabolites could be detected in locusts (103).
  Endosulfan is very toxic to fish and caused many fish deaths when the Rhine River became contaminated in June 1969 (concentration was 0.1 ppm). The only residues detected in fish exposed to acute and multiple subchronic concentrations of endosulfan were endosulfan and the diol and the glucuronic acid conjugate of the diol.

• Lager

  Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in a cool, dry, well-ventilated area, free ofalkalis, acids, and acid fumes. Where possible, automatically pump liquid from drums or other storage containers toprocess containers

• Versand/Shipping

  UN2761 Organochlorine pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

• Degradation

  Endosulfan is slowly hydrolysed in aqueous acids and alkalies with the formation of the diol(2) and sulfur dioxide.
  Endosulfan is stable to sunlight but UV irradiation in solution gave a number of products, the identity of which depended on the medium in which photolysis took place (see Scheme 1) (Schumaker ef al., 1973). The photolytic processes include reductive dechlorination and when the α-isomer was irradiated in n-hexane, dechlorination took place at the double bond to give 10, whereas in water-dioxane, it occurred at the methylene bridge with the formation of 9. The products formed in the vapour phase included the diol(2), the ether (4), the lactone (6), the cyclic sulfate (3), and other products characterised as dechlorinated compounds (7 and 8).
  The β-isomer of endosulfan gave compounds 11 and 12 in dioxane and 11 in n-hexane-acetone.

• Toxicity evaluation

  Endosulfan was not carcinogenic in the rat or mouse in chronic dietary studies. It was not genotoxic in a variety of tests. Kidney toxicity was observed in the rat at dietary levels of 100 ppm (5 mg/kg/day) and above. Clinical signs of hyperactivity and tremors were reported in many studies. No evidence was found of developmental or reproductive toxicity.

• Inkompatibilitäten

  Those engaged in the manufacture, formulation, and application of this material

• Waste disposal

  A recommended method for disposal is burial 18 in deep in noncropland, away from water supplies, but bags can be burned. Large quantities should be incinerated at high temperature in a unit with effluent gas scrubbing. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/ mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

Thiosulfan Upstream-Materialien And Downstream Produkte

Endosulfan (ISO) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(132)Suppliers

115-29-7, Thiosulfan Verwandte Suche: