Hexachlorethan

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H319：Verursacht schwere Augenreizung.

  H351：Kann vermutlich Krebs verursachen.

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P202：Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P308+P313：BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

Hexachloroethane Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE KRISTALLE MIT CHARAKTERISTISCHEM GERUCH.

• CHEMISCHE GEFAHREN

  Zersetzung beim Erhitzen über 300°C unter Bildung giftiger und ätzender Rauche, Phosgen (s. ICSC 0007) und Chlorwasserstoff (s. ICSC 0163). Reagiert heftig mit Zink, Aluminiumpulver und Natrium. Greift Eisen in Gegenwart von Feuchtigkeit an.

• ARBEITSPLATZGRENZWERTE

  TLV: 1 ppm (als TWA) Hautresorption Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
  MAK: 1 ppm 9,8 mg/m?Spitzenbegrenzung: überschreitungsfaktor II(2); (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation, über die Hautund durch Verschlucken.

• INHALATIONSGEFAHREN

  Beim Verdampfen bei 20 °C kann sehr schnell eine gesundheitsschädliche Kontamination der Luft eintreten.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Exposition kann zu Bewusstlosigkeit führen.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Möglich sind Auswirkungen auf Leber und Nieren. Exposition weit über den Arbeitsplatzgrenzwerten kann Auswirkungen auf das Zentralnervensystem (Zittern und Koordinationsstörungen) haben.

• LECKAGE

  Verschüttetes Material in Behältern sammeln. Reste sorgfältig sammeln. An sicheren Ort bringen.

• R-Sätze Betriebsanweisung:

  R40:Verdacht auf krebserzeugende Wirkung.
  R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
  R36/38:Reizt die Augen und die Haut.
  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  R11:Leichtentzündlich.

• S-Sätze Betriebsanweisung:

  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S24:Berührung mit der Haut vermeiden.
  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S7:Behälter dicht geschlossen halten.

• Beschreibung

  Hexachloroethane (HCE) is a halogenated hydrocarbon consisting of six chlorines attached to an ethane (ACGIH, 1991); it is a white to pale yellow solid that is unstable in air and evaporates gradually. It smells like camphor when its concentration in air and water are 150 and 10 ppb, respectively. HCE itself does not catch fire easily; however; in aqueous nonbiological conditions it has been determined that HCE is unstable and nonenzymatic dechlorination in the absence of nicotinamide adenine dinucleotide phosphate (NADP) occurs. It rapidly degrades in soil or groundwater. Also, some microorganisms break down HCE without oxygen, and decomposition in aerobic conditions has been reported. Some bioconcentration of HCE in fish has been determined, though upper levels through the food chain are limited, since it is rapidly metabolized by fish, which is discussed later (ATSDR, 1997).
  Eyes, skin, respiratory system, and kidneys have been proposed as main targets in humans upon exposure. Symptoms include blinking, tearing, photophobia, and irritation of eyes. Also, facial muscles may have difficulty in movement. Animal studies on effects of HCE during pregnancy are limited. After oral exposure, HCE is primarily distributed to fat tissue. Toxicokinetic studies in animals indicated that HCE is mostly localized and metabolized in the liver and kidney. Several corresponded metabolites have demonstrated liver and kidney toxicities similar to HCE. Neurological effects such as tremors and ataxia were observed in Beagle dogs, rats, and pregnant rats. Other effects via inhalation exposure included reduced body weight and increased relative liver weight in rats and guinea pigs. In another study, male rats also displayed increased relative spleen and testes weight. Based on California Proposition 65, HCE was proposed to be carcinogenic for humans, and it induces tumors at sites other than the site of entry. Noncancerous effects include kidney degeneration (tubular nephropathy, necrosis of renal tubular epithelium, hyaline droplet formation, tubular regeneration, and tubular casts) and hepatocellular necrosis. It results in hyaline droplet nephropathy and renal toxicity, and it induces chromosome malsegregation, lethality, and mitotic growth arrest (Crebelli et al., 1995, 1992, 1988).

• Chemische Eigenschaften

  white crystalline powder

• Chemische Eigenschaften

  Hexachloroethane is a white solid with a camphor-like odor. It gradually evaporates when it is exposed to air.

• Physikalische Eigenschaften

  Rhombic, triclinic or cubic, colorless crystals with a camphor-like odor. Odor threshold concentration is 0.15 ppm (quoted, Amoore and Hautala, 1983).

• Verwenden

  The applications of hexachloroethane have been extensive; however, industrial uses are diminishing. Hexachloroethane is used primarily in military smoke munitions (e.g., smoke pots, grenades, cartridges, and projectiles used to generate “smoke” or “fog”) and in pyrotechnics.
  The estimated average annual use of hexachloroethane from 1966 to 1977 at a major facility manufacturing smoke and pyrotechnic devices was 192,802 lb. In the 1970s, about half of the hexachloroethane distributed was used to manufacture military smoke-producing and pyrotechnic devices, 30% to 40% to manufacture degassing pellets to remove air bubbles from molten ore at aluminum foundries, and 10% to 20% as an antihelminthic to control liver flukes in sheep and cattle. The U.S. Food and Drug Administration withdrew approval for the use of hexachloroethane as an antihelminthic in 1971, and it probably is no longer used for this purpose (ATSDR 1997). Its use for degassing aluminum also has been almost completely phased out in the United States (EPA 1999). Other uses in metallurgy include refining alloys, removing impurities from molten metals, recovering metals from ores or smelting products, and as a degassing agent for magnesium; however, the European Union began phasing out the use of hexachloroethane in nonferrous metals in 1998 (EC 1998).
  A number of other past uses of hexachloroethane have been identified, but many of these likely have been discontinued or involve the use of only limited quantities. Hexachloroethane is used as a laboratory chemical and as an ingredient in various fungicidal and insecticidal formulations, extreme-pressure lubricants, and plastics (ATSDR 1997, IARC 1999, HSDB 2009). Other past uses include as a moth repellent and in the chemical industry as a polymer additive, a plasticizer for cellulose esters, an accelerator, a vulcanizing agent, a process solvent in rubber manufacturing, a retardant in fermentation processes, and a component of submarine paints, and in the production of some types of synthetic diamonds. It has also been used as a component of fire-extinguishing fluids, an additive in combustible liquids (ignition suppressant), and an inhibitor of the explosiveness of methane and the combustion of ammonium perchlorate (IARC 1979, 1999, HSDB 2009).

• Verwenden

  Hexachloroethane is used as a solvent, infireworks and smoke devices; in explosives,in celluloid, as an insecticide, and as a rubbervulcanizing accelerator. Earlier it was used asan anthelmintic for livestock. Hexachloroethane is a highly efficient chlorinating agent in the preparation of chlorosilanes from hydrosilanes.

• Verwenden

  In metallurgy for refining aluminum alloys, removing impurities from molten metals, recovering metal from ores or smelting products. Degassing agent for magnesium; to inhibit explosiveness of methane and combustion of ammonium perchlorate. Smoke generator in grenades; in pyrotechnics. Ignition suppressant, in fire extinguishing fluids, polymer additive, flame-proofing agent, vulcanizing agent. In production of synthetic diamonds.

• Definition

  ChEBI: A member of the class of chloroethanes that is ethane in which all the hydrogens are replaced by chloro groups.

• Allgemeine Beschreibung

  Hexachloroethane is a colorless, crystalline solid with a camphor-like odor. Hexachloroethane may cause illness from inhalation or ingestion and may irritate skin, eyes and mucous membranes. When heated to high temperatures Hexachloroethane may emit toxic fumes. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Hexachloroethane is used to make other chemicals.

• Air & Water Reaktionen

  Insoluble in water.

• Reaktivität anzeigen

  Hexachloroethane can react with hot iron, zinc and aluminum. Dehalogenation of Hexachloroethane by reaction with alkalis and metals will produce unstable chloroacetylenes. Hexachloroethane can also react with strong oxidizing agents. .

• Hazard

  Toxic by ingestion and inhalation, strong irritant, absorbed by skin. Possible carcinogen.

• Health Hazard

  Vapors of hexachloroethane are an irritant tothe eyes and mucous membranes. Oral dosesof 1000 mg/kg produced weakness, stagger ing gait, and twitching muscles in dogs.Rabbits fed 1000 mg/kg for 12 days devel oped necrosis; a lower amount, 320 mg/kg,caused liver degeneration; no effects wereobserved at a dose level of 100 mg/kg(Weeks 1979).
  Acute inhalation toxicity is of a loworder in animals. Subacute toxic effectsin dogs exposed to 260-ppm vapors ofhexachloroethane for 6 hours per day, 5days a week for 6 weeks were tremors,ataxia, hypersalivation, head bobbling, andfacial muscular fasciculations (Weeks 1979).The lethal concentration in rats is 5900 ppmfrom an 8-hour exposure.
  LD50 value, oral (rats): 4460 mg/kg
  Tests for mutagenicity and teratogenic ity were negative. The carcinogenic poten tial of hexachloroethane was noted in testanimals only at extremely heavy dosagesgiven continuously for a long period of time(ACGIH 1986). It caused liver tumors inmice.

• Health Hazard

  Compound is a powerful narcotic and liver poison; may also cause changes in blood composition and neurological disturbances. Repeated exposure by inhalation can be fatal. Ingestion causes vomiting, diarrhea, severe mucosal injury, liver necrosis, cyanosis, unconsciousness, loss of reflexes, and death. Contact with eyes causes irritation and lachrymation. Can be absorbed through the skin and may produce severe skin lesions.

• Brandgefahr

  Special Hazards of Combustion Products: Irritating hydrogen chloride vapor may form in fire.

• mögliche Exposition

  In the US, about half the HCE is used by the military for smoke-producing devices. It is also used to remove air bubbles in melted aluminum. It may be present as an ingredient in some fungicides, insecticides, lubricants, and plastics. It is no longer made in the United States, but it is formed as a by-product in the production of some chemicals. Can be formed by incinerators when mate rials containing chlorinated hydrocarbons are burned. Some HCE can also be formed when chlorine reacts with carbon compounds in drinking water. As a medicinal, HCE is used as an anthelmintic to treat fascioliasis in sheep and cattle. It is also added to the feed of ruminants, preventing metha nogenesis and increasing feed efficiency. HCE is used in metal and alloy production, mainly in refining aluminum alloys. It is also used for removing impurities from molten metals, recovering metals from ores or smelting products and improving the quality of various metals and alloys. HCE is contained in pyrotechnics. It inhibits the explosive ness of methane and the combustion of ammonium perchlo rate. Smoke containing HCE is used to extinguish fires. HCE has various applications as a polymer additive. It has flameproofing qualities, increases sensitivity to radiation crosslinking, and is used as a vulcanizing agent. Added to polymer fibers, HCE acts as a swelling agent and increases affinity for dyes.

• Erste Hilfe

  If this chemical gets into the eyes, remove anycontact lenses at once andirrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contactsthe skin, remove contaminated clothing and wash immedi-ately with soap and water. Seek medical attention immedi-ately. If this chemical has been inhaled, remove fromexposure, begin rescue breathing (using universal precau-tions，includingIresuscitation1 mask) if breathing hasstopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quanti-ties of water and induce vomiting. Do not make an uncon-scious person vomit.

• Carcinogenicity

  Hexachloroethane is reasonably anticipated to be ogen based on sufficient evidence of carcinogenicit a human carciny from studies in experimental animals.

• Environmental Fate

  Biological. Under aerobic conditions or in experimental systems containing mixed cultures, hexachloroethane was reported to degrade to tetrachloroethane (Vogel et al., 1987). In an uninhibited anoxic-sediment water suspension, hexachloroethane degraded to tetrachloroethylene. The reported half-life for this transformation was 19.7 min (Jafvert and Wolfe, 1987). When hexachloroethane (5 and 10 mg/L) was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum for 7 d, 100% biodegradation with rapid adaptation was observed (Tabak et al., 1981).
  Photolytic. When an aqueous solution containing hexachloroethane was photooxidized by UV light at 90–95 °C, 25, 50, and 75% degraded to carbon dioxide after 25.2, 93.7, and 172.0 h, respectively (Knoevenagel and Himmelreich, 1976).
  Chemical/Physical. The reported hydrolysis half-life at 25 °C and pH 7 is 1.8 x 10⁹ yr (Jeffers et al., 1989). No hydrolysis was observed after 13 d at 85 °C and pH values of 3, 7, and 11 (Ellington et al., 1987). Similarly, no measureable hydrolysis was observed under neutral and alkaline conditions (Jeffers and Wolfe, 1996).

• Lager

  Color Code- Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Hexachloroethane must be stored to avoid contactwith hot iron, zinc， aluminum, and alkalis since violentreactions occur. Store in tightly closed containers in a cool,well-ventilated area away from heat. A regulated, markedarea should be established where this chemical is handled,used, or stored in compliance with OSHA Standard1910.1045.

• Versand/Shipping

  UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

• läuterung methode

  Steam distil it, then crystallise it from 95% EtOH. Dry it in the dark under vacuum. [Beilstein 1 IV 148.]

• Toxicity evaluation

  Reports on human health effects are limited and confounded by coexposure to multiple solvents or other toxicants (e.g., HCE-zinc oxide smoke), and are too small to provide definitive conclusions on health effects. Animal studies suggest that HCE is primarily metabolized to tetrachloroethylene (PERC) and pentachloroethane by CYP450 enzymes of the liver, with likely subsequent metabolism to TCE. Metabolites identified in the urine include TCA, trichloroethanol, oxalic acid, dichloroethanol, dichloroacetic acid, and monochloroacetic acid (Gorzinski et al., 1985).
  Studies of TCA (a potential metabolite of HCE) indicate that free-radical generation may play a role in mediating toxicity, particularly in the liver. However, no data are available demonstrating generation of free radicals following exposure to HCE, and it is unknown whether unchanged HCE or its metabolites are responsible for the liver and kidney toxicities observed in animal studies. Lipid peroxidation was reported by formation of malondialdehyde and conjugated dienes, which involves free radicals (Town et al., 1984). In another study, the presence of radiolabeled carbon measured by in vivo binding studies suggested that HCE can bind to DNA, RNA, and protein. Therefore, renal toxicity and hepatotoxicity may also involve HCE binding to DNA, RNA, or protein, resulting in cytotoxicity and contributing to the cytotoxic damage from radicals. Another hypothesis is the data that a α2u-globulin mode of action could contribute to HCE-induced nephropathy but they are not sufficient.

• Inkompatibilitäten

  Incompatible with strong acids, oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from strong bases.

• Waste disposal

  Incineration after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids pro duced. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must con form to EPA regulations governing storage, transportation, treatment, and waste disposal.

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