Calciumdobesilat

Bezeichnung:Calciumdobesilat

CAS-Nr20123-80-2

Englisch Name:Calcium dobesilate

CBNumberCB5713183

Summenformel2C6H5O5S.Ca

Molgewicht418.41

MOL-Datei20123-80-2.mol

Synonyma

Calciumdobesilat

Calciumdobesilat physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300° (dec)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	H2O: soluble15mg/mL, clear
Aggregatzustand	powder
Farbe	white to beige
Wasserlöslichkeit	H2O: 15mg/mL, clear
Stabilität	Hygroscopic
InChIKey	QGNBTYAQAPLTMX-UHFFFAOYSA-L
CAS Datenbank	20123-80-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26
WGK Germany	3
HazardClass	IRRITANT
Toxizität	LD50 in mice: 700 mg/kg (Esteve-Subirana)

Gefahreninformationscode (GHS)

Calcium dobesilate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Calcium dobesilate is a vasoprotective. It is the calcium salt of dobesilic acid. It is a synthetic molecule with the ability to reduce capillary permeability in the body. In Switzerland the drug is sold by the pharmaceutical company OM Pharma under the trade name of Doxium in capsules containing 500 mg of active ingredient.
Calcium dobesilate is indicated in states of fragility and altered capillary permeability, e.g. diabetic retinopathy, chronic venous disease and hemorrhoidal disease. In combination with lidocaine or with lidocaine and dexamethasone, the drug enters the composition of preparations for the therapy of hemorrhoidal disease. In association with potassium hydrodex-sulfate[citation needed] enters the composition of adjuvant gels in the treatment of varicose veins. The efficacy of calcium dobesilate has been described in patients with microangiopathies such as diabetic retinopathy and diabetic nephropathy.
Chemische Eigenschaften
White or almost white, hygroscopic powder.
Originator
Doxium,Carrion,France,1971
Verwenden
Calcium dobesilate is an antioxidant that has been used to treat diabetic retinopathy, in which it slows progression of the disease during long-term oral treatment by reducing microvascular permeability, leading to improved visual acuity. It not only acts as an antioxidant but also stimulates endothelial production of nitric oxide.
Verwenden
Dobesilate calcium has been used to study its interference in different in vitro assay systems for the determination of creatinine, uric acid, cholesterol, and triglycerides.
Indications
Calcium dobesilate (CaD) is a widely prescribed veno-tonic drug for CVI, diabetic retinopathy, and the symptoms of hemorrhoid attacks.
Calcium dobesilate is also almost the only one angioprotective drug that recently remains the object of interest in treatment of diabetic retinopathy including clinical studies (Leal et al. 2010, Einarsdottir & Stefansson, 2009, Ribeiro et al., 2006), and even it was used as a standard for determination of the particular activity of a traditional Chinese herbal medicine preparation (Luo et al. 2009).
Manufacturing Process
To an ether solution of 108 grams 1,4-benzoquinone, maintained below 0°C, one adds an also very cold solution of 102 grams of pure calcium bisulfite as a 50% solution in distilled water. The addition is made carefully so as to maintain a very low temperature (0° to 4°C) in the vessel, and under stirring so as to mix the water and ether phase.
At the end of the addition, an almost colorless ether layer swims on the surface of the strongly colored water layer. After removal of the ether layer, the water layer is concentrated to dryness under vacuum and a stream of an inert gas. An earthy precipitate is formed, which after recrystallization yields 100 grams of hydroquinone calcium sulfonate, which decomposes without melting above 250°C.
The product consists of very small crystals having a powdery aspect and a pink color which deepens on contact with air. This product is very soluble in water and alcohol, and insoluble in ether.
Therapeutic Function
Vasodilator
Allgemeine Beschreibung
Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.
Biochem/physiol Actions
Dobesilate Calcium is a vasoprotectant used as a treatment for chronic venous disease, diabetic retinopathy and other microvascular disorders. Its mechanism of action is not fully understood. It appears that dobesilate calcium increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase and decreasing capillary hyperpermeability. Also in diabetic retinopathy dobesilate calcium prevents the blood-retinal barrier breakdown induced by diabetes by restoration of the tight junction protein, and decreasing the leukocyte adhesion to retinal vessels.
Nebenwirkungen
Fever
Skin reactions
Arthralgia(joint pain)
Gastrointestinal disorders
Agranulocytosis (lower white blood cell count)
Mode of action
Calcium dobesilate is a vaosactive drug used in the management of diabetic retinopathy and venous insufficiency. Calcium dobesilate's mechanism of action is thought to be related to decreasing tissue edema by altering vascular permeability and platelet aggregation. Mentes and colleagues randomized 29 patients with symptomatic hemorrhoids to calcium dobesilate and a high-fiber diet or to a highfiber diet alone. Eighty-six percent of patients treated with calcium dobesilate described cessation of bleeding and improvement in perianal irritation.

Calcium dobesilate Upstream-Materialien And Downstream Produkte

Calciumdobesilat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

20123-80-2, Calcium dobesilate Verwandte Suche:

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