Travoprost

Bezeichnung:Travoprost

CAS-Nr157283-68-6

Englisch Name:Travoprost

CBNumberCB5703458

SummenformelC26H35F3O6

Molgewicht500.55

MOL-Datei157283-68-6.mol

Travoprost physikalisch-chemischer Eigenschaften

alpha	D20 +14.6° (c = 1.0 in methylene chloride)
Siedepunkt	584.8±50.0 °C(Predicted)
Dichte	1.245±0.06 g/cm3(Predicted)
Flammpunkt	17 °C
storage temp.	Sealed in dry,Store in freezer, under -20°C
Löslichkeit	Dichloromethane (Sparingly, Sonicated), Chloroform (Sparingy), Methanol (Sparing
Aggregatzustand	ethanol solution
pka	13.43±0.20(Predicted)
Farbe	Colourless to Light Beige
BCS Class	2
Stabilität	Light Sensitive
InChIKey	MKPLKVHSHYCHOC-AHTXBMBWSA-N
CAS Datenbank	157283-68-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	F,Xi
R-Sätze:	11-36/37/38
S-Sätze:	16-26-36-7
RIDADR	UN 1170 3/PG 2
WGK Germany	1
HS Code	2937500000

Gefahreninformationscode (GHS)

Travoprost Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Travoprost was launched in the US as Travatan?, an ophthalmic solution (0.004%) administered topically for the treatment of elevated intraocular hypertension (lOP) through open-angle glaucoma, a common optic neuropathy and a leading cause of blindness. Travoprost is the isopropyl ester of (+)-fluprostenol, a new prostaglandin derivative belonging to the PGF_2α, analog class. This compound can be prepared in 8 steps from a bicyclic lactone aldehyde by a Wittig alkylidenation followed, after 2 ketonic reductions, by a lactol opening to prostenoic acid while protecting and deprotecting appropriately. Travoprost is a full agonist of FP receptors with a greater affinity than PGF_2α, (K₁ = 52 nM). Pharmacologic studies in rabbits treated daily for a week demonstrated a significant increase of the microvascular optic nerve head blood flow without significant alterations in the systemic flow. In several placebo-controlled clinical studies with hundreds of patients suffering from open-angle glaucoma or ocular hypertension, travoprost (1 to 4 pm daily) dose-dependently reduced lOP (by about 30% at 4 pm); it was shown equal or superior to latanoprost, another prostaglandin analog (5 pm daily) or the adrenergic ~-blocker timolol (500 pm bid). In addition, travoprost was safe and well tolerated with a low incidence of conjunctival hyperaemia.
Chemische Eigenschaften
Colorless Oil
Originator
Alcon (US)
Verwenden
Travoprost is a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).
Verwenden
treatment conditions arising from excess uric acid, eg chronic gout
Verwenden
Selective FP prostaglandin receptor agonist. Isopropyl ester of (+)-fluprostenol. Antiglaucoma
Definition
ChEBI: The isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophth lmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the co nea to the biologically active free acid, fluprostenol.
Trademarks
Travatan
Allgemeine Beschreibung
Travoprost (Travatan and Travatan-Z) is supplied asa 2.5- or 5.0-mL sterile 0.004% ophthalmic solution in a4.0- or 7.5-mL size container. Travoprost is claimed to bethe most potent and FP-specific analog in this product category. Cautions and side effects are similar to those givenpreviously.

Travoprost Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

157283-68-6, Travoprost Verwandte Suche:

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