3'-Amino-3'-desoxy-N,N-dimethyladenosin

Bezeichnung:3'-Amino-3'-desoxy-N,N-dimethyladenosin

CAS-Nr58-60-6

Englisch Name:PUROMYCIN AMINONUCLEOSIDE

CBNumberCB5455647

SummenformelC12H18N6O3

Molgewicht294.31

MOL-Datei58-60-6.mol

Synonyma

3'-Amino-3'-desoxy-N,N-dimethyladenosin

3'-Amino-3'-desoxy-N,N-dimethyladenosin physikalisch-chemischer Eigenschaften

Schmelzpunkt	235℃ (Decomposition)
Siedepunkt	436.08°C (rough estimate)
Dichte	1.2131 (rough estimate)
Brechungsindex	1.7000 (estimate)
Flammpunkt	>110°(230°F)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	H₂O: 50 mg/mL, clear, slightly yellow
Aggregatzustand	liquid
pka	13.26±0.70(Predicted)
Farbe	White
Wasserlöslichkeit	Soluble in water at 50mg/ml. May require heating
BRN	93902
Stabilität	Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
InChIKey	RYSMHWILUNYBFW-GRIPGOBMSA-N
EPA chemische Informationen	Adenosine, 3'-amino-3'-deoxy-N,N-dimethyl- (58-60-6)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	48/22
WGK Germany	3
RTECS-Nr.	AU7337000
F	10-21
TSCA	Yes
HS Code	29419090

Gefahreninformationscode (GHS)

PUROMYCIN AMINONUCLEOSIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Puromycin aminonucleoside (58-60-6) is the nucleoside moiety of puromycin (Cat.# 10-2100) which does not inhibit protein synthesis or induce apoptosis.1?It acts as a glomerular epithelial cell toxin2 and as such is a useful tool for producing animal models of nephropathy3,4, or puromycin aminonucleoside nephrosis (1-2.5 mg/100g rat body weight)5. Active in vivo.
Chemische Eigenschaften
White crystal
Verwenden
Puromycin aminonucleoside is a semi-synthetic derivative of puromycin which lacks the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis, but exhibits antitumour properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing integrin expression in cultured glomerular epithelial cells.
Verwenden
Puromycin Aminonucleoside is an aminonucleoside portion of the antibiotic puromycin.
Definition
ChEBI: Puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring.
Sicherheitsprofil
An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx,.
Einzelnachweise
1) Chow et al. (1995), Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis; Exp. Cell Res., 216 149 2) Krishnamurti et al. (2001), Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells; J. Am. Soc. Nephrol., 12 758 3) Egashira et al. (2006), Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis; Int. J. Vitam. Nutr. Res., 76 28 4) Hagiwara et al. (2006), Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis; Kidney Int., 69 1146 5) Lowenborg et al. (2000), Glomerular function and morphology in puromycin aminonucleoside nephropathy in rats; Nephrol. Dial. Transplant, 15 1547

PUROMYCIN AMINONUCLEOSIDE Upstream-Materialien And Downstream Produkte

3'-Amino-3'-desoxy-N,N-dimethyladenosin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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