Isopropylpalmitat

Bezeichnung:Isopropylpalmitat

CAS-Nr142-91-6

Englisch Name:Isopropyl palmitate

CBNumberCB0451826

SummenformelC19H38O2

Molgewicht298.5

MOL-Datei142-91-6.mol

Synonyma

Isopropylpalmitat

Isopropylpalmitat physikalisch-chemischer Eigenschaften

Schmelzpunkt	11-13 °C (lit.)
Siedepunkt	160°C 2mm
Dichte	0.852 g/mL at 25 °C (lit.)
Dampfdruck	0.007Pa at 25℃
Brechungsindex	n20/D 1.438(lit.)
Flammpunkt	>230 °F
storage temp.	2-8°C
Löslichkeit	<0.001g/l
Farbe	Colourless
Geruch (Odor)	very sl. odor
Wasserlöslichkeit	Not miscible or difficult to mix with water.
BRN	1786567
InChIKey	XUGNVMKQXJXZCD-UHFFFAOYSA-N
LogP	8.16
CAS Datenbank	142-91-6(CAS DataBase Reference)
NIST chemische Informationen	Isopropyl palmitate(142-91-6)
EPA chemische Informationen	Isopropyl palmitate (142-91-6)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/38-36/37/38
S-Sätze:	26-36
WGK Germany	-
RTECS-Nr.	RT4900000
TSCA	Yes
HS Code	29157090
Giftige Stoffe Daten	142-91-6(Hazardous Substances Data)
Toxizität	mouse,LD50,intraperitoneal,100mg/kg (100mg/kg),National Technical Information Service. Vol. AD277-689,

Gefahreninformationscode (GHS)

Isopropyl palmitate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/38:Reizt die Augen und die Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Clear colorless liquid
Chemische Eigenschaften
Isopropyl palmitate is a clear, colorless to pale yellow-colored, practically odorless viscous liquid that solidifies at less than 16°C.
Verwenden
Pharmaceutic aid (vehicle, oleaginous).
Verwenden
Isopropyl palmitate is used to formulate and evaluate the suitability of pluronic lecithin organogels containing flurbiprofen for topical application and to characterize microemulsion systems of isopropyl palmitate, water and 2:1 Brij 97, and 1-butanol by different experimental techniques.
Verwenden
isopropyl palmitate is an emollient and moisturizer, it also acts as a binder and solvent. Similar to isopropyl myristate, it is produced from the combination of palmitic acid (coconut or palm oil) and isopropyl alcohol. enzymes are able to metabolize this ingredient and studies do not show allergic reactions or toxicity. Some sources indicate comedogenicity potential.
Definition
ChEBI: Isopropyl palmitate is a fatty acid ester obtained by the formal condensation of carboxy group of palmitic acid with propan-2-ol. Metabolite observed in cancer metabolism. It has a role as a human metabolite. It is a fatty acid ester and an isopropyl ester. It is functionally related to a hexadecanoic acid.
Vorbereitung Methode
Isopropyl palmitate is prepared by the reaction of palmitic acid with propan-2-ol in the presence of an acid catalyst. A high-purity material is also commercially available, which is produced by enzymatic esterification at low temperatures.
Allgemeine Beschreibung
Isopropyl palmitate is an analog of isopropyl myristate and an aliphatic ester used as a flavoring ingredient in food industry. It is one of the volatile compounds found in Psidium salutare fruits and boiled buckwheat flour.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmazeutische Anwendungen
Isopropyl palmitate is a nongreasy emollient with good spreading characteristics, used in topical pharmaceutical formulations and cosmetics such as: bath oils; creams; lotions; make-up; hair care products; deodorants; lip products; suntan preparations; and pressed powders.
Isopropyl palmitate is an established penetration enhancer for transdermal systems. It has also been used in controlled-release percutaneous films. Table I: Uses of isopropyl palmitate
Nebenwirkungen
Side effects for the skin: If overused, isopropyl palmitate may cause acne, blackheads, whiteheads, and clogged pores. Depending on the content of the ingredients in the product, the skin may experience some irritation. If isopropyl palmitate is used without dilution, it may cause comedoles. People with oily skin should also avoid isopropyl palmitate.
Side effects for hair: Excessive use of products containing isopropyl palmitate on hair can make hair look untidy, oily, and untidy due to excessive moisture in the hair. When there is an open wound on the scalp, isopropyl palmitate should also be avoided.
Sicherheit(Safety)
Isopropyl palmitate is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material.
LD50 (mouse, IP): 0.1 g/kg
Lager
Isopropyl palmitate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container, above 16°C, and protected from light.
Regulatory Status
Included in the FDA Inactive Ingredients Database (topical and transdermal preparations). Used in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Isopropyl palmitate Upstream-Materialien And Downstream Produkte

Isopropylpalmitat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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