Arbidol hydrochloride

Bezeichnung:Arbidol hydrochloride

CAS-Nr131707-23-8

Englisch Name:Arbidol hydrochloride

CBNumberCB5438596

SummenformelC22H26BrClN2O3S

Molgewicht513.88

MOL-Datei131707-23-8.mol

Arbidol hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	133-137?C
storage temp.	-20°C
Löslichkeit	DMSO: soluble20mg/mL protein, clear
Aggregatzustand	powder
Farbe	white to beige
Stabilität	Hygroscopic
InChI	InChI=1S/C22H25BrN2O3S.ClH/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3;/h6-11,26H,5,12-13H2,1-4H3;1H
InChIKey	OMZHXQXQJGCSKN-UHFFFAOYSA-N
SMILES	C(C1=C(N(C)C2=CC(Br)=C(O)C(CN(C)C)=C12)CSC1C=CC=CC=1)(=O)OCC.Cl
CAS Datenbank	131707-23-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/38
S-Sätze:	26
WGK Germany	3
Toxizität	guinea pig,LD50,oral,> 3gm/kg (3000mg/kg),Drugs of the Future. Vol. 17, Pg. 1079, 1992.

Gefahreninformationscode (GHS)

Arbidol hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Umifenovir is a broad-spectrum antiviral agent. It inhibits the replication of H5N1 influenza (IC₅₀ = 30 μg/ml) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro (IC₅₀ = 3.537 μM). Umifenovir inhibits entry of hepatitis C virus (HCV) pseudoparticles in Huh7 cells (IC₅₀ = 6 μg/ml) and inhibits Zika virus protein synthesis in Vero cells. In vivo, umifenovir (45 mg/kg) reduces the formation of influenza-induced lung lesions in ferrets.
Chemische Eigenschaften
Off White to Pale Yellow Solid
Verwenden
Arbidol hydrochloride (ARB) is a small monocular compound. It is used to prevent severe pneumonia and virus-associated cytokine dysregulation induced by influenza viruses (IFV). ARB also possesses some immunomodulatory properties, including the effects of interferon induction and macrophage activation.
Arbidol is a broad-spectrum antiviral that has demonstrated activity against a number of enveloped and non-enveloped viruses, and is used clinically to treat influenza. Arbidol inhibits viral entry into host cell and stimulates immune response. Arbidol inhibits fusion between the viral capsid and the cell membrane of the target cell, thus preventing viral entry.
Verwenden
Arbidol is an antiviral treatment for influenza infection.
Biochem/physiol Actions
Arbidol hydrochloride (ARB) is a small monocular compound. It is used to prevent severe pneumonia and virus-associated cytokine dysregulation induced by influenza viruses (IFV). ARB also possesses some immunomodulatory properties, including the effects of interferon induction and macrophage activation.
Lager
Store at -20°C
Einzelnachweise
1) Blasing?et al.?(2014), Arbidol as a broad-spectrum antiviral: an update; Antiviral Res,?107?84 2) Boriskin?et al. (2008) Arbidol: a broad-spectrum antiviral compound that blocks viral fusion; Curr. Med. Chem.,?15?997 3) Brooks?et al.?(2012) Antiviral activity of Arbidol, a broad-spectrum drug for use against respiratory viruses, varies according to test conditions; J. Med. Virol.,?84?170 4) Leneva?et al.?(2009)?Characteristics of Arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol; Antiviral Res.,?81?132 5) Wang?et al.?(2020)?The anti-influenza drug, arbidol, is an efficient inhibitor of SARS-CoV-2 in vitro; Cell Discov.,?6?28 6) Vankadari?(2020)?Arbidol: A Potential Antiviral Drug for the Treatment of SARS-CoV-2 by Blocking Trimerization of the Spike Glycoprotein; Int. J. Antimicrob. Agents, 56 105998

Arbidol hydrochloride Upstream-Materialien And Downstream Produkte

Arbidol hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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