Boc-D-Ser(Bzl)-OH

Bezeichnung:Boc-D-Ser(Bzl)-OH

CAS-Nr47173-80-8

Englisch Name:Boc-D-Ser(Bzl)-OH

CBNumberCB5438415

SummenformelC15H21NO5

Molgewicht295.33

MOL-Datei47173-80-8.mol

Boc-D-Ser(Bzl)-OH physikalisch-chemischer Eigenschaften

Schmelzpunkt	58-60 °C(lit.)
alpha	-19 º (c=2 80% alcohol)
Siedepunkt	437.02°C (rough estimate)
Dichte	1.1454 (rough estimate)
Brechungsindex	-20 ° (C=2, 80% EtOH)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	almost transparency in Methanol
pka	3.53±0.10(Predicted)
Aggregatzustand	Powder
Farbe	White
BRN	2665080
InChI	InChI=1S/C15H21NO5/c1-15(2,3)21-14(19)16-12(13(17)18)10-20-9-11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,16,19)(H,17,18)/t12-/m1/s1
InChIKey	DMBKPDOAQVGTST-GFCCVEGCSA-N
SMILES	C(O)(=O)[C@@H](COCC1=CC=CC=C1)NC(OC(C)(C)C)=O
CAS Datenbank	47173-80-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-36/37/38
S-Sätze:	24/25-36-26
WGK Germany	3
HS Code	2924 29 70
HazardClass	IRRITANT

Gefahreninformationscode (GHS)

Boc-D-Ser(Bzl)-OH Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White crystalline powder
Verwenden
N-BOC-O-Benzyl-D-serine, is an amino acid derivative used in chemical synthesis and peptide chemistry.is used in preparation of substituted naphthyl thiadiazolidinones as protein tyrosine phosphatase degraders for treating cancer and metabolic diseases.
Biologische Aktivität
Boc-O-benzyl-D-serine is an inhibitor of the uptake of galactose and its derivatives. It has potent inhibitory activity against the uptake of galactose, glucose, and lactose. This drug is also effective in inhibiting the uptake of tetrazole, a substance that inhibits glycolysis. Boc-O-benzyl-D-serine is able to inhibit atherosclerotic lesions caused by piperidine, which has been shown to be synthesized from benzyl alcohol and piperidine. The oral administration of this compound can enhance fibroblast cells that are resistant to insulin.
Synthese
N-Boc D-Se (500 mg, 2.43 mmol) dissolved in anhydrous DMF (4 mL) was slowly added to a dispersion of 60% NaH (204 mg, 5.1 mmol) in anhydrous DMF at 0 ° C. Stir the mixture at room temperature for 1 hour and cool to 0 ° C. Subsequently, benzyl bromide (0.29 mL, 2.43 mmol) was added and the mixture was heated to room temperature. After 4 hours of reaction, add saturated NH4Cl (1 mL) to quench the reaction. Finally, the product Boc-D-Ser(Bzl)-OH was obtained through purification.

Boc-D-Ser(Bzl)-OH Upstream-Materialien And Downstream Produkte

Boc-D-Ser(Bzl)-OH Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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