3-Mercaptopropan-1,2-diol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H311：Giftig bei Hautkontakt.

  H315：Verursacht Hautreizungen.

  H317：Kann allergische Hautreaktionen verursachen.

• Sicherheit

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

3-Mercapto-1,2-propanediol Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R21/22:Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken.
  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).

• Beschreibung

  1-Thioglycerol is a reagent used in fluorescence, spectroscopy, and microbiology techniques. Varying the concentration of 1-thioglycerol in the preparation of CdSe/CdS core-shell ultrasmall quantum dots (CS-USQDs) allows a precise way to control the size of the shell, with shell size increasing with increased concentration. It is used as a capping agent in the synthesis of nanocrystals analyzed via Raman and UV/Vis spectroscopy. Biologically, 1-thioglycerol stimulates porphyrin synthesis and increases glutamyl-tRNA reductase activity in E. coli grown in an aerobic environment. It was previously a component in hair permanents used to produce waves or curls.

• Chemische Eigenschaften

  clear colorless to yellowish viscous solution

• Chemische Eigenschaften

  Monothioglycerol occurs as a colorless or pale-yellow colored, viscous, hygroscopic liquid with a slight odor of sulfide.

• Verwenden

  It generally used as a size-regulating capping agent for nanocrystals. 1-Thioglycerol is also used in bacteriology experiments to induce the synthesis of porphyrin compounds in aerobically growing Escherichia coli. Also used to study the pH-sensitive photoluminescence of aqueous thiol-capped CdTe nanocrystals. 1-Thioglycerol is used to develop and test thiol functionalized copolymers. 1-Thioglycerol is used as a post-modification agent in the generation of non-standard peptide foldamers.Potential substitute for 2-mercaptoethanol, probe for the study of lymphocyte activation.

• Verwenden

  3-Mercapto-1,2-propanediol can be used as antioxidant preservative; reagent in analytical chemistry, cell culture research. Matrix substrate in fast atom bombardment mass spectrometry.

• Verwenden

  3-Mercapto-1,2-propanediol has been used in a study to assess the manipulation of aqueous growth of CdTe nanocrystals. It has also been used in a study that investigated the effect of surface attachment on ligand binding

• Definition

  ChEBI: A thiol that is glycerol in which one of the primary hydroxy groups is replaced by a thiol group.

• Vorbereitung Methode

  Monothioglycerol is prepared by heating an ethanolic solution of 3- chloro-1,2-propanediol with potassium bisulfide.

• Allgemeine Beschreibung

  1-Thioglycerol stimulates the synthesis of porphyrin in aerobically growing Escherichia coli. It is an inhibitor of glycerol kinase activity in vitro and in situ.

• Pharmazeutische Anwendungen

  Monothioglycerol is used as an antioxidant in pharmaceutical formulations, mainly in parenteral preparations.Monothioglycerol is reported to have some antimicrobial activity.It is also widely used in cosmetic formulations such as depilating agents.
  Therapeutically, monothioglycerol has been used in a 0.02% w/w aqueous solution to stimulate wound healing, and as a 0.1% w/w jelly in atrophic rhinitis.

• Sicherheitsprofil

  Poison by intraperitoneal and intravenous routes. Experimental reproductive effects. Mutation data reported. Flammable when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits hghly toxic fumes of SOx.

• Sicherheit(Safety)

  Monothioglycerol is generally regarded as a relatively nontoxic and nonirritant material at the concentrations used as a pharmaceutical excipient. It is used in topical and injectable preparations. Undiluted monothioglycerol is considered a poison by the IP and IV routes; it has also been reported to be mutagenic.
  LD₅₀ (cat, IV): 0.22 g/kg
  LD₅₀ (mouse, IP): 0.34 g/kg
  LD₅₀ (rabbit, IV): 0.25 g/kg
  LD₅₀ (rat, IP): 0.39 g/kg

• Lager

  Monothioglycerol is unstable in alkaline solutions. Monothioglycerol should be stored in a well-closed container in a cool, dry place.

• Inkompatibilitäten

  Monothioglycerol can react with oxidizing materials.

• Regulatory Status

  Included in the FDA Inactive Ingredients Database (IM, IV and other injections). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

• Einzelnachweise

  [1] ANIELLE CHRISTINE A. SILVA. Shell Thickness Modulation in Ultrasmall CdSe/CdSxSe1–x/CdS Core/Shell Quantum Dots via 1-Thioglycerol[J]. ACS Nano, 2014, 8 2: 1913-1922. DOI: 10.1021/nn406478f
  [2] YANFEI WANG. Raman scattering study of molecules adsorbed on ZnS nanocrystals[J]. Journal of Raman Spectroscopy, 2006, 38 1: 34-38. DOI: 10.1002/jrs.1570
  [3] M. T. HARRISON. Wet Chemical Synthesis of Highly Luminescent HgTe/CdS Core/Shell Nanocrystals[J]. Advanced Materials, 1999, 12 2: 123-125. DOI: 10.1002/(sici)1521-4095(200001)12:2<123::aid-adma123>3.0.co;2-h
  [4] G T JAVOR  E F F. Enzymatic basis of thiol-stimulated secretion of porphyrins by Escherichia coli.[J]. Journal of Bacteriology, 1992, 174 3: 1072-1075. DOI: 10.1128/jb.174.3.1072-1075.1992
  [5] LEHMAN A J. HEALTH ASPECTS OF COMMON CHEMICALS USED IN HAIR-WAVING PREPARATIONS[J]. JAMA neurology, 1949, 27 7 1: 842-845. DOI: 10.1001/jama.1949.62910120002010

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