2,3-Epoxy-1-propanol

Bezeichnung:2,3-Epoxy-1-propanol

CAS-Nr556-52-5

Englisch Name:Glycidol

CBNumberCB5338946

SummenformelC3H6O2

Molgewicht74.08

MOL-Datei556-52-5.mol

Synonyma

2,3-Epoxypropan-1-ol

2,3-Epoxy-1-propanol

Oxiranmethanol

2,3-Epoxy-1-propanol physikalisch-chemischer Eigenschaften

Schmelzpunkt	-54 °C
Siedepunkt	61-62 °C/15 mmHg (lit.)
Dichte	1.117 g/mL at 25 °C (lit.)
Dampfdichte	2.15 (vs air)
Dampfdruck	0.9 mm Hg ( 25 °C)
Brechungsindex	n20/D 1.433(lit.)
Flammpunkt	178 °F
storage temp.	-20°C
Löslichkeit	Soluble in acetone, alcohol, benzene, chloroform, and ether (Weast, 1986)
pka	14.62±0.10(Predicted)
Aggregatzustand	Powder, Crystals or Chunks
Farbe	White to light yellow-beige
Wasserlöslichkeit	soluble
Merck	13,4503
BRN	383562
Expositionsgrenzwerte	TLV-TWA 75 mg/m³ (25 ppm) (ACGIH); 150 mg/m³ (50 ppm) (OSHA); IDLH 500 ppm (NIOSH).
Stabilität	Stability Stable, but may explode on contact with strong acids, strong bases, heavy metals, heavy metal salts. May decompose on exposure to water or moist air.
InChIKey	CTKINSOISVBQLD-UHFFFAOYSA-N
LogP	-0.95 at 25℃
CAS Datenbank	556-52-5(CAS DataBase Reference)
IARC	2A (Vol. 77) 2000
NIST chemische Informationen	Glycidol(556-52-5)
EPA chemische Informationen	Glycidol (556-52-5)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	45-60-21/22-23-36/37/38-68
S-Sätze:	53-45-36/37-26
RIDADR	UN 2810 6.1/PG 3
WGK Germany	3
RTECS-Nr.	UB4375000
F	10-21
Selbstentzündungstemperatur	780 °F
Hazard Note	Toxic
HazardClass	6.1(b)
PackingGroup	III
HS Code	29109000
Giftige Stoffe Daten	556-52-5(Hazardous Substances Data)
Toxizität	Acute oral LD50 for mice 431 mg/kg, rats 420 mg/kg (quoted, RTECS, 1985).
IDLA	150 ppm

Gefahreninformationscode (GHS)

Glycidol Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE LEICHT VISKOSE FLüSSIGKEIT.
CHEMISCHE GEFAHREN
Kann polymerisieren Zersetzung bei Kontakt mit starken Säuren und Basen, Metallsalzen oder Metallen unter Feuer- und Explosionsgefahr. Greift Kunststoff und Gummi an.
ARBEITSPLATZGRENZWERTE
TLV: 2 ppm (als TWA); Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
MAK: Hautresorption; Krebserzeugend Kategorie 2; (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation der Dämpfe, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C kann schnell eine gesundheitsschädliche Kontamination der Luft eintreten.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen, die Haut und die Atemwege. Möglich sind Auswirkungen auf das Zentralnervensystem. Exposition weit oberhalb der Arbeitsplatzgrenzwerte kann Bewusstseinstrübung verursachen.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wahrscheinlich krebserzeugend für den Menschen. Tierversuche zeigen, dass die Substanz möglicherweise fruchtbarkeitsschädigend oder entwicklungsschädigend wirken kann.
LECKAGE
Persönliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät. Ausgelaufene Flüssigkeit möglichst in abdichtbaren Glas- oder Weichstahlbehältern sammeln. Reste mit trockenem Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen.
R-Sätze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R21/22:Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken.
R23:Giftig beim Einatmen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R68:Irreversibler Schaden möglich.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Glycidol is a chiral molecule with epoxide and primary alcohol functional groups. It is racemic mixture and exists in the dextrorotatory and the levorotatory enantiomeric forms. Several synthetic methods are available for preparation of glycidol. However, it is commercially prepared from the epoxidation of allyl alcohol with hydrogen peroxide and a catalyst (tungsten or vanadium), or from the reaction of epichlorohydrin with caustic. Glycidol has been used in the industrial synthesis of pharmaceutical products since the 1970s. However, its use for research purposes has been reported since 1956. Available information indicates that glycidol is manufactured by several companies in Japan, Germany, and the United States.
Chemische Eigenschaften
colourless liquid
Chemische Eigenschaften
Glycidol is a colorless liquid.
Verwenden

Glycidol is a Stabilizer in the manufacture of vinyl polymers; chemical intermediate in preparation of glycerol, glycidyl ethers, esters, and amines; in pharmaceuticals; in sanitary chemicals.
Verwenden
Stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.
Verwenden
Glycidol is used as a stabilizer for natural oilsand vinyl polymers, as a demulsifier, and asa leveling agent for dyes.
Definition
an epoxide
Allgemeine Beschreibung
Odorless clear colorless liquid.
Air & Water Reaktionen
Sensitive to moisture.
Reaktivität anzeigen
Glycidol is sensitive to moisture. Glycidol is also sensitive to light. Glycidol may polymerize if heated above room temperature. Glycidol may darken on storage. Stability studies of Glycidol stored for two week protected from light indicated definite decomposition at 140° F, and strongly indicated instability at 77° F. A solution of Glycidol in water was found to be unstable when stored at room temperature, even after one day in the dark. Glycidol is incompatible with strong oxidizers. Glycidol will undergo explosive decomposition in the presence of strong acids or bases, salts (such as aluminum chloride, iron(III)chloride or tin(IV) chloride) or metals (such as copper and zinc). Glycidol is also incompatible with nitrates. Glycidol will attack some forms of plastics, rubber and coatings.
Hazard
Toxic material. Probable carcinogen.
Health Hazard
Glycidol is an eye, lung, and skin irri-tant. The pure compound caused severebut reversible corneal injury in rabbit eyes(ACGIH 1986). Exposure to its vapor causedirritation of lung in mice, resulting in pneu-monitis. There is no evidence of any cumula-tive toxicity. From the limited toxicity data,it appears that the health hazard to humansfrom its exposure is, primarily, respiratoryirritation, stimulation of the central nervoussystem, and depression.
Glycidol is mutagenic, testing positive inthe histidine reversion–Ames test. There isno report of its carcinogenic action. Oraland intraperitoneal administration of gly-cidol in rats showed harmful effects onfertility.
Brandgefahr
Glycidol is combustible.
Flammability and Explosibility
Non flammable
Sicherheitsprofil
Confirmed carcinogen with carcinogenic data reported. Poison by intraperitoneal route. Moderately toxic by ingestion, inhalation, and sh contact. Experimental teratogenic and reproductive effects. A skin irritant. Human mutation data reported. Animal experiments suggest somewhat lower toxicity than for related epoxy compounds. Readdy absorbed through the skin. Causes nervous excitation followed by depression. Explodes when heated or in the presence of strong acids,bases, metals (e.g., copper, zinc), and metal salts (e.g., aluminum chloride, iron(II1) chloride, tin(Iy chloride). When heated to decomposition it emits acrid smoke and fumes. See also DIGLYCIDYL ETHER.
mögliche Exposition
Glycidol is used as an intermediate in the synthesis of glycerol, glycidyl ethers, esters, and amines.
Carcinogenicity
Glycidol is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
Chemical/Physical. May hydrolyze in water forming glycerin (Lyman et al., 1982).
Versand/Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
läuterung methode
[S(-)-isomer, § also available on polymer support, has b 49-50o/7mm, 66-67o/19mm, [ ] D -1 5o(neat)], [R(+)-isomer has b 56 -5 6 . 5o/11mm, d 4 1.117, n D 1.429, [ ] D +15o (neat)]. Purify glycidol by fractional distillation.
Toxicity evaluation
Glycidol is a small molecule possessing a chemically reactive epoxide group. Therefore, it acts as a direct alkylating agent. Nucleophilic bioactive compounds such as glutathione react readily with glycidol. Glycidol decreases glutathione content in rat liver by direct binding to the glutathione. In vitro experiments revealed that glycidol reacts with purified DNA to form the DNA adducts. This is likely to be responsible for the genotoxic activity of the compound without a requirement for metabolic activation.
Inkompatibilitäten
May form explosive mixture with air. Violent reaction with strong oxidizers, nitrates. Decomposes on contact (especially in the presence of heat) with strong acids, strong bases, water, metal salts, e.g., alu minum chloride, ferric chloride, and tin chloride), or metals (copper and zinc), causing fire and explosion hazard. Contact with barium, lithium, sodium, magnesium, and tita nium may cause polymerization. Attacks some plastics, rubber, and coatings.
Waste disposal
Concentrated waste contain ing no peroxides: discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxides: perforation of a container of the waste from a safe distance followed by open burning.

Glycidol Upstream-Materialien And Downstream Produkte

2,3-Epoxy-1-propanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

556-52-5, Glycidol Verwandte Suche:

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