Acexaminsure

Bezeichnung:Acexaminsure

CAS-Nr57-08-9

Englisch Name:6-Acetamidohexanoic acid

CBNumberCB5168240

SummenformelC8H15NO3

Molgewicht173.21

MOL-Datei57-08-9.mol

Synonyma

Acexaminsure

Acexaminsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	102-104 °C(lit.)
Siedepunkt	303.86°C (rough estimate)
Dichte	1.1599 (rough estimate)
Brechungsindex	1.4590 (estimate)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO (Sparingly), Methanol (Slightly)
pka	4.75±0.10(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
Merck	14,45
LogP	-0.500 (est)
CAS Datenbank	57-08-9(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	3
HS Code	29241900

Gefahreninformationscode (GHS)

6-Acetamidohexanoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
WHITE POWDER
Originator
Acexamic acid ,Flamma
Verwenden
wound healing agent
Verwenden
6-Acetamidohexanoic acid is used after oral administration of an antiulcer agent, zinc acexamate (ZAC) for treatment of gastric ulcer or small bowel inflammation.
Definition
ChEBI: Acexamic acid is a medium-chain fatty acid.
Manufacturing Process
400 L of demineralized water, 5.0 kg of calcium hydroxide, and 155.0 kg (1000 moles) of acetyl-caprolactame are introduced under stirring and at a temperature of about 25°C into a 1000 L stainless double walled reactor.
The temperature is raised to 30°C. 75.0 kg of calcium hydroxide are introduced stepwise in the form of successive amounts of 2.0 kg each in the medium, under stirring and at a temperature adjusted and maintained 25°- 30°C through external cooling, in a manner such that the time required to introduce into the reactor the whole amount of calcium hydroxide approximates 1.5 h. When the stirring is stopped, the pH is about 7.5-7.8.
The obtained mixture is stirred continuously at a temperature of 30°C during 14 h. At the end of this operation the pH is again adjusted at a value 7.5-7.8.
The hydrolysate is filtered on a 60 x 60 pressfilter comprising 6 compartments and equipped with fabrics of the polyester known under the designation TERGAL which have been previously coated with a suspension of a cellulose commercialized under the trademark SOLKA FLOX BW20. The duration of filtration is of 1.5 h. 580 L of the filtrate are recovered and subjected to a concentration under reduced pressure in an evaporator the volume of which is of 750 L, at a distillation temperature ranging from 45°-50°C under a reduced pressure of 10-15 Torr.
The operation is ran until concentration of the solution to 280 L, the concentrated solution being then left standing. The crystallisation is already considerable 2 h after the end of the operation of concentration. Crystallisation is ended after 16-24 h.
The crystals are centrifuged at a speed of 700 revolutions/minute. The centrifuged crystals of calcium acexamate are washed twice on the centrifuge with 20 l of acetone. 107.0 kg of crystals are obtained, which are dried under vacuum at 40°C. The 96.0 kg of dry calcium acexamate obtained are ground and sifted.
Acexamic acid may be produced by treatment of the calcium acexamate with HCl.
Therapeutic Function
Antifibrinolytic

6-Acetamidohexanoic acid Upstream-Materialien And Downstream Produkte

Acexaminsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

57-08-9, 6-Acetamidohexanoic acid Verwandte Suche:

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