N-ε-Acetyl-L-lysin

Bezeichnung:N-ε-Acetyl-L-lysin

CAS-Nr692-04-6

Englisch Name:N-EPSILON-ACETYL-L-LYSINE

CBNumberCB3308387

SummenformelC8H16N2O3

Molgewicht188.22

MOL-Datei692-04-6.mol

Synonyma

N-ε-Acetyl-L-lysin

N-ε-Acetyl-L-lysin physikalisch-chemischer Eigenschaften

Schmelzpunkt	250 °C (dec.)(lit.)
Siedepunkt	323.23°C (rough estimate)
Dichte	1.1793 (rough estimate)
Brechungsindex	1.4500 (estimate)
storage temp.	-20°C
Löslichkeit	Aqueous Base (Slightly), Water (Slightly)
Aggregatzustand	Powder
pka	2.53±0.24(Predicted)
Farbe	White
Wasserlöslichkeit	Soluble in water (miscible), and 80% acetic acid (50 mg/ml).
Sensitive	Hygroscopic
InChIKey	DTERQYGMUDWYAZ-ZETCQYMHSA-N
CAS Datenbank	692-04-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	24/25-36-26
WGK Germany	3
HS Code	29241900

Gefahreninformationscode (GHS)

N-EPSILON-ACETYL-L-LYSINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Acetyllysine (or acetylated lysine) is an acetyl-derivative of the amino acid lysine. There are multiple forms of acetyllysine - this article refers to N-ε-acetyl-L-lysine. The other form is N-α-acetyl-Llysine.
In proteins, the acetylation of lysine residues is an important mechanism of epigenetics. It functions by regulating the binding of histones to DNA in nucleosomes and thereby controlling the expression of genes on that DNA. Non-histone proteins are acetylated as well. Unlike the functionally similar methyllysine, acetyllysine does not carry a positive charge on its side chain.
Histone acetyltransferases (HATs) catalyze the addition of acetyl groups from acetyl-CoA onto certain lysine residues of histones and non-histone proteins. Histone deacetylases (HDACs) catalyze the removal of acetyl groups from acetylated lysines.
Acetyllysine can be synthesized from lysine by the selective acetylation of the terminal amine group.
Chemische Eigenschaften
white crystalline powder
Verwenden
N-Epsilon-acetyl-l-lysine is used in the metabolomics study on the combined effect of cocaine and ethanol via liquid chromatography-mass spectrometry metabolomics approach.
Definition
ChEBI: An N6-acyl-L-lysine where the N6-acyl group is specified as acetyl.
Biochem/physiol Actions
Nε-Acetyl-L-lysine (L-AcK) is an R-chain N-acetylated α amino acid used together with other lysine analogues to differentiate and characterized various aminoacylases and regulator 2 (Sir2) enzymes/sirtuins.

N-ε-Acetyl-L-lysin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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