Benzidin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H350：Kann Krebs verursachen.

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P201：Vor Gebrauch besondere Anweisungen einholen.

  P202：Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P273：Freisetzung in die Umwelt vermeiden.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P308+P313：BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

Benzidine Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  WEISSES ODER RöTLICHES KRISTALLINES PULVER; VERFäRBT SICH DUNKEL BEI KONTAKT MIT LUFT UND LICHT.

• CHEMISCHE GEFAHREN

  Zersetzung beim Erhitzen und Verbrennen unter Bildung giftiger Rauche mit Stickstoffoxiden. Reagiert sehr heftig mit starken Oxidationsmitteln, vor allem Salpetersäure.

• ARBEITSPLATZGRENZWERTE

  TLV: Hautresorption Krebskategorie A1(bestätigte krebserzeugende Wirkung beim Menschen); (ACGIH 2005).
  MAK: Hautresorption; Krebserzeugend Kategorie 1; (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation des Aerosols, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Dispergieren schnell erreicht werden, vor allem als Pulver.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Krebserzeugend für den Menschen.

• LECKAGE

  Gefahrenbereich verlassen! Fachmann zu Rate ziehen! Persönliche Schutzausrüstung: Vollschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät. NICHT in die Umwelt gelangen lassen. Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen.

• R-Sätze Betriebsanweisung:

  R45:Kann Krebs erzeugen.
  R22:Gesundheitsschädlich beim Verschlucken.
  R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
  R52/53:Schädlich für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
  R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  R11:Leichtentzündlich.
  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

• S-Sätze Betriebsanweisung:

  S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S7:Behälter dicht geschlossen halten.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

• Aussehen Eigenschaften

  (4,4'-Diaminobiphenyl, 4,4'-Diaminodiphenyl, Paradiaminodiphenyl, p,p'-Bianilin). Weißes oder schwach rötliches, mitunter grau-gelbliches Pulver, Kristalle oder Blättchen.

• Gefahren für Mensch und Umwelt

  Benzidin ist einer der für den Menschen sicher krebserzeugenden Stoffe. Es entwickeln sich nach einer z.T. 20-jährigen Latenzzeit Blasentumore. Benzidin kann sehr leicht durch die Haut aber auch durch Einatmen durch Einatmen von Dampf oder Staub aufgenommen werden.Es wirkt blutschädigend und schwächend auf das Knochenmark. Nach Verschlucken entstehen Übelkeit und Erbrechen unter Umständen mit nachfolgenden Leber- und Nierenschäden.

• Schutzmaßnahmen und Verhaltensregeln

  Nur in geschlossenen Apparaturen arbeiten. Staubbildung unbedingt vermeiden (möglichst wasserfeuchtes Produkt verwenden). Gefäße nicht offen stehenlassen. Keinen Vorrat aufbewahren. Benutzte Geräte nach der Arbeit sofort gründlich reinigen.
  Schutzhandschuhe aus Gummi (nur als kurzzeitiger Spritz- bzw. Staubschutz).
  Vorbeugender Hautschutz (Arbeitsschutzcreme) erforderlich.
  Benzidin und seine Salze sind unter Verschluß an einem gut belüfteten Ort aufzubewahren.

• Verhalten im Gefahrfall

  Verschüttete Substanz vorsichtig aufnehmen. Inhalt zerstörter Behältnisse der Wiederverwendung zuführen oder ordnungsgemäß entsorgen.
  Substanz brennt selbst nur schwer. Löschmaßnahmen auf Umgebung abstimmen.
  Bildung nitroser Gase! Bei Lösch- und Aufräumungsarbeiten Hautkontakt und Einatmen von Staub unbedingt vermeiden.

• Erste Hilfe

  Nach Hautkontakt: Betroffene Haut mit reichlich Polyethylenglykol, notfalls mit leicht angesäuertem Wasser (Essig) waschen. Auf keinen Fall Alkohol verwenden.
  Nach Augenkontakt: Unter fließendem Wasser bei geöffnetem Lidspalt mindestens 15 Minuten spülen. Anschließend Isogutt-Augentropfen einbringen. Augenarzt!
  Nach Einatmen: Frischluft! Arzt!
  Nach Verschlucken: Nach Verschlucken sofort wiederholt Wasser mit reichlich Aktivkohlezusatz trinken lassen. Arzt!
  Nach Kleidungskontakt: Verunreinigte Kleidung sofort ausziehen!
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Als Sondermüll entsorgen.

• Beschreibung

  Benzidine is a white, greyish-yellow, or slightly reddish crystalline solid or powder. The major use for benzidine is in the production of dyes, especially azo dyes in the leather, textile, and paper industries and as a synthetic precursor in the preparation and manufacture of dyestuffs. It is also used in the manufacture of rubber, as a reagent, and as a stain in microscopy. It is slightly soluble and slowly changes from a solid to a gas.

• Chemische Eigenschaften

  Off-White Solid

• Chemische Eigenschaften

  Benzidine is a white, grayish-yellow crystalline solid or powder. Turns brownish-red on exposure to air and light;

• Chemische Eigenschaften

  Benzidine is a white, grayish-yellow, or slightly reddish crystalline solid or powder. The major use for benzidine is in the production of dyes, especially azo dyes in the leather, textile, and paper industries, as a synthetic precursor in the preparation and manufacture of dyestuffs. It is also used in the manufacture of dyes and rubber, as a reagent, and as a stain in microscopy. It is slightly soluble and slowly changes from a solid to a gas.

• Physikalische Eigenschaften

  Grayish-yellow to pale reddish powder or crystals. Darkens on exposure to air or light. Odorless.

• Verwenden

  Benzidine was used extensively in the manu facture of dyes. Because of its cancer-causingeffects in humans, its application in dyes hasbeen curtailed. Other uses of this compoundare in chemical analysis: as a reagent for thedetermination of hydrogen peroxide in milkand in the analysis of nicotine. Its hydrochlo ride is used as a reagent to analyze metalsand sulfate.

• Verwenden

  Manufacture of dyestuffs; hardener for rubber; laboratory reagent

• Verwenden

  Potentially mutagenic compound.

• synthetische

  1-Nitrobenzene restore 1,2-Diphenylhydrazine?turn with acid rearrangement.

• Vorbereitung Methode

  Benzidine production is now exclusively for captive consumption and must be carried out in closed systems under stringent workplace controls. Benzidine is used in the synthesisofdyesanddyeintermediates,asahardenerforrubber, and as a laboratory reagent. The ?rst successful synthetic direct dye was Congo Red, a diazo derivative prepared from benzidinebyBoettigerin1884.Nearlyalldirectdyesareazo products. Congo Red is used in humans intravenously for the medical diagnosis of amyloidosis. The basis for its use is an unexplained af?nity for amyloid, which rapidly removes the dye from the blood. It is used medically for the management of profuse capillary hemorrhage such as the one occurring in septicemias and in the terminal phases of leukemia.

• Definition

  ChEBI: A member of the class of biphenyls that is 1,1'-biphenyl in which the hydrogen at the para-position of each phenyl group has been replaced by an amino group.

• Synthesis Reference(s)

  The Journal of Organic Chemistry, 41, p. 2661, 1976 DOI: 10.1021/jo00877a041
  Synthesis, p. 40, 1976 DOI: 10.1055/s-1976-23952

• Allgemeine Beschreibung

  A grayish-yellow to grayish-red, crystalline solid. Toxic by ingestion, inhalation, and skin absorption. Combustion produces toxic oxides of nitrogen. Used to make other chemicals and in chemical and biological analysis.

• Air & Water Reaktionen

  Darkens on exposure to air and light. Soluble in hot water.

• Reaktivität anzeigen

  Benzidine forms insoluble salts with sulfuric acid. Can be diazotized, acetylated and alkylated. Is hypergolic with red fuming nitric acid . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

• Hazard

  Highly toxic by ingestion, inhalation, and skin absorption. Confirmed carcinogen.

• Health Hazard

  Exposure to benzidine causes irritation to the eyes. Laboratory animals exposed to benzidine at as low as 0.01% to 0.08% in food showed adverse health effects, such as organ weight decrease in the liver, kidney, and body weight, and an increase in spleen weight, swelling of the liver, and blood in the urine. Exposure may cause an increase in urination, blood in the urine, and urinary tract tumors. Benzidine is considered acutely toxic to humans by ingestion, with an estimated oral lethal dose of between 50 and 500 mg/kg. The symptoms of acute ingestion exposure include cyanosis, headache, mental confusion, nausea, and vertigo. Dermal exposure may cause skin rashes and irritation. Prolonged exposure to benzidine causes bladder injury in humans

• Health Hazard

  Benzidine is a known carcinogen, causingbladder cancer in humans. Numerous reportsin the literature document its carcinogenicityin animals and humans. Oral or subcutaneousapplication of this compound in experimentalanimals produced tumors in liver, blood,lungs, and skin. The routes of entry intohuman body are primarily the inhalation of its dusts and absorption through skin. Whilehumans and dogs develop bladder cancerfrom benzidine, rodents primarily developliver cancer.Relatively little information is availableon the noncancer health hazard from ben zidine. The acute oral toxicity in animalswas moderate. Ingestion can produce nausea,vomiting, kidney, and liver damage. The oralLD50 values in test animals were in the range150–300 mg/kg.The mechanism of carcinogenicity of ben zidine is thought to involve its metabolictransformations forming reactive intermedi ates binding to DNA. Such DNA adductshave been identified in rodent liver. It testedpositive in most genotoxic tests. Its car cinogenicity may possibly be related to theslow rate of liver detoxification by acetyla tion allowing activation of benzidine or itsmetabolites in urine (Whysner et al. 1996)..

• Health Hazard

  Poisonous if inhaled, swallowed or absorbed through skin. May cause contact dermatitis, irritation or sensitization. Ingestion may cause nausea and vomiting.

• Sicherheitsprofil

  Confirmed human carcinogen producing bladder tumors. Experimental carcinogenic and tumorigenic data. Poison by ingestion and intraperitoneal routes. Human mutation data reported. Can cause damage to blood, including hemolysis and bone marrow depression. On ingestion causes nausea and vomiting, which may be followed by liver and kidney damage. Any exposure is considered extremely hazardous. When heated to decomposition it emits highly toxic fumes of NOx. See also AROMATIC AMINES.

• mögliche Exposition

  Benzidine is used primarily in the manufacture of azo dyestuffs; there are over 250 of these produced. Other uses, including some which may have been discontinued, are in the rubber industry as a hardener; in the manufacture of plastic films; for detection of occult blood in feces, urine, and body fluids; in the detection of H2O2 in milk; in the production of security paper; and as a laboratory reagent in determining HCN, sulfate, nicotine, and certain sugars. No substitute has been found for its use in dyes. Free benzidine is present in the benzidine-derived azo dyes. According to industry, quality control specifications require that the level not exceed 20 ppm and in practice the level is usually below 10 ppm. Regulations in the USA concerning this chemical define strict procedures to avoid worker contact: mixture containing 0.1% or more must be maintained in isolated or closed systems; employees must observe special personal hygiene rules, and certain procedures must be followed in case of emergencies. Some p-phenylenediamine compounds have been used as rubber components, and DFG warns of danger of skin sensitization. Benzidine and dyes metabolized to benzidine: The following three benzidine-based dyes have been tested and found to cause cancer in rodents after oral exposure for 13 weeks (NCI 1978, IARC 1982): C.I. direct black 38 (CAS 1937-37-7) caused liver cancer in rats and mice, mammary-gland cancer in mice, and colon and urinary-bladder cancer in rats. C.I. direct Blue 6 (CAS 2602-46-2) caused liver cancer in rats. C.I. direct brown 95 (CAS 16071-86-6) caused hepatocellular adenoma in the liver and one malignant liver tumor in rats.

• Erste Hilfe

  If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Use gastric lavage if ingested followed bysaline catharsis. Medical observation is recommended for24-48 h after breathing overexposure, as pulmonary edemamay be delayed. As first aid for pulmonary edema, a doctoror authorized paramedic may consider administering a corticosteroid spray.

• Carcinogenicity

  Benzidine is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.

• Source

  Benzidine can enter the environment by transport, use, and disposal, or by dyes and pigments containing the compound. A photodegradation product of 3,3′-dichlorobenzidine.
  Based on laboratory analysis of 7 coal tar samples, benzidine was ND (EPRI, 1990).

• Environmental Fate

  Biological. In activated sludge, <0.1% mineralized to carbon dioxide after 5 d (Freitag et al., 1985). Kincannon and Lin (1985) reported a half-life of 76 d when benzidine in sludge was applied to a sandy loam soil.
  Soil. Benzidine was added to different soils and incubated in the dark at 23 °C under a carbon dioxide-free atmosphere. After 1 yr, 8.3 to 11.6% of the added benzidine degraded to carbon dioxide primarily by microbial metabolism and partially by hydrolysis (Graveel et al., 1986). Tentatively identified biooxidation compounds using GC/MS include hydroxybenzidine, 3- hydroxybenzidine, 4-amino-4′-nitrobiphenyl, N,N′-dihydroxybenzidine, 3,3′-dihydroxybenzidine and 4,4′-dinitrobiphenyl (Baird et al., 1977). Under aerobic conditions, the half-life was estimated to be 2 to 8 d (Lu et al., 1977).
  Chemical/Physical. Benzidine is not subject to hydrolysis (Kollig, 1993). Reacts with HCl forming a salt (C12H12N2?2HCl) that is very soluble in water (61.7 mg/L at 25 °C) (Bowman et al., 1976).

• Lager

  Benzidine should be kept stored in a cool, well-ventilated area, in closed, sealed containers and out of sunlight and away from heat.

• Versand/Shipping

  UN1885 Benzidine, Hazard Class: 6.1; Labels: 6.1—Poisonous materials. PGII.

• läuterung methode

  Its solution in *benzene is decolorized by percolating through two 2-cm columns of activated alumina, then concentrated until benzidine crystallises on cooling. Recrystallise alternately from EtOH and *benzene to constant absorption spectrum [Carlin et al. J Am Chem Soc 73 1002 1951]. It has also been crystallised from hot water (charcoal) and from diethyl ether. Dry it under vacuum in an Abderhalden pistol. Store it in the dark in a stoppered container. CARCINOGENIC. [Beilstein 13 IV 364.]

• Properties and Applications

  white or pink micro crystalline powder. Melting point 125 ℃, boiling point 400 ℃, relative density 1.250 (20 ℃). Soluble in ethanol, rare hydrochloric acid and acetic acid boiling, slightly soluble in ethyl ether, slightly soluble in water, very slightly soluble in cold water. In the air and light color line darker. This product is the dye and organic pigments intermediate.

• Toxicity evaluation

  Industries release benzidine into the environment in the form of liquid waste and sludges. Benzidine may also be released into the environment due to spillage during transport. In air, benzidine is found bound to suspended particles or as a vapor, which may be brought back to the earth’s surface by rain or gravity.

• Inkompatibilitäten

  Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. On contact with strong reducing agents, such as hydrides may form flammable gases. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with red fuming nitric acid may cause fire. Oxidizes in air. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.

• Waste disposal

  Incineration; oxides of nitrogen are removed from the effluent gas by scrubber, catalytic or thermal device. Package spill residues and sorbent media in 17 hour epoxy-lined drums and move to an EPA-approved disposal site. Treatment may include destruction by potassium permanganate oxidation, hightemperature incineration, or microwave plasma methods. 398 Benzidine Encapsulation by organic polyester resin or silicate fixation. These disposal procedures should be confirmed with responsible environmental engineering and regulatory officials.

• Vorsichtsmaßnahmen

  At high temperatures, benzidine breaks down and releases highly poisonous fumes. During use and handling, workers should wear butyl rubber gloves, goggles, and full body plastic coveralls and ensure that no skin is exposed.

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