(±)-2-(tert-Butylamino)-3'-chlorpropiophenonhydrochlorid

Bezeichnung:(±)-2-(tert-Butylamino)-3'-chlorpropiophenonhydrochlorid

CAS-Nr31677-93-7

Englisch Name:Bupropion hydrochloride

CBNumberCB5140066

SummenformelC13H19Cl2NO

Molgewicht276.2

MOL-Datei31677-93-7.mol

Synonyma

(±)-2-(tert-Butylamino)-3'-chlorpropiophenonhydrochlorid

(±)-2-(tert-Butylamino)-3'-chlorpropiophenonhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	233-234 °C
Flammpunkt	9℃
storage temp.	Desiccate at RT
Löslichkeit	ethanol: 193 mg/mL solutions may be stored for several days at 4 °C.
Aggregatzustand	solid
Farbe	white
Wasserlöslichkeit	Soluble in water (>25 mg/ml), ethanol 193mg/ml, 0.1 N HCl 333 mg/ml
CAS Datenbank	31677-93-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi,T,F
R-Sätze:	22-39/23/24/25-23/24/25-11
S-Sätze:	36-45-36/37-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS-Nr.	UG8858000
HS Code	29223990

Gefahreninformationscode (GHS)

Bupropion hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Bupropion hydrochloride powder is white, crystalline, and highly soluble in water. It has a bitter taste and produces the sensation of local anesthesia on the oral mucosa.
Originator
Bupropion hydrochloride,AroKor Holdings Inc.
Arzneimittelwechselwirkung
Relatively few data are available on interactions of bupropion hydrochloride with other drugs. Increased adverse experiences were reported when the drug was administered concomitantly with l-dopa. MAOIs may increase the acute toxicity of bupropion.
Although bupropion is not metabolized by the CYP2D6 enzyme, the drug and its metabolite, morpholinol, inhibit this enzyme in vitro. Therefore, extreme caution should be exercised when coadministering any drug metabolized by that enzyme, and initial dosage of the drug should be as low as possible.
Verwenden
Bupropion hydrochloride is indicated for the treatment of MDD. Bupropion hydrochloride SR (Zyban) is indicated as an aid to smoking cessation treatment.
Trademarks
Wellbutrin (GlaxoSmithKline); Zyban (GlaxoSmithKline).
Therapeutic Function
Antidepressant; Smoking cessation aid
Biologische Aktivität
Non-selective inhibitor of dopamine and noradrenalin transporters (K i values are 1.4, 2.8 and 45 μ M for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo .
Nebenwirkungen
Bupropion hydrochloride can cause serious side effects. The most common side effects of Bupropion hydrochloride include:
headache
dizziness
dry mouth
sore throat
nausea
constipation
trouble sleeping
Mode of action
The exact mechanism of the antidepressant action of bupropion is not known, but is presumed to be related to noradrenergic and/or dopaminergic mechanisms. Bupropion is a relatively weak inhibitor of the neuronal reuptake of norepinephrine and dopamine, and does not inhibit the reuptake of serotonin. Bupropion does not inhibit monoamine oxidase.

Bupropion hydrochloride Upstream-Materialien And Downstream Produkte

31677-93-7, Bupropion hydrochloride Verwandte Suche:

Send Inquriy