2-Amino-6-fluoropyridine

Bezeichnung:2-Amino-6-fluoropyridine

CAS-Nr1597-32-6

Englisch Name:2-Amino-6-fluoropyridine

CBNumberCB4438746

SummenformelC5H5FN2

Molgewicht112.11

MOL-Datei1597-32-6.mol

2-Amino-6-fluoropyridine physikalisch-chemischer Eigenschaften

Schmelzpunkt	59-61°C
Siedepunkt	225.0±20.0 °C(Predicted)
Dichte	1.257±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	soluble in Methanol
Aggregatzustand	powder to crystal
pka	2.26±0.24(Predicted)
Farbe	White to Almost white
InChI	InChI=1S/C5H5FN2/c6-4-2-1-3-5(7)8-4/h1-3H,(H2,7,8)
InChIKey	UZALKVXCOUSWSL-UHFFFAOYSA-N
SMILES	C1(N)=NC(F)=CC=C1
CAS Datenbank	1597-32-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-22
S-Sätze:	26-36/37/39
WGK Germany	3
Hazard Note	Irritant
HazardClass	6.1
HS Code	2933399990
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

2-Amino-6-fluoropyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
2-Amino-6-fluoropyridine is an organic intermediate that can be prepared via the nucleophilic substitution reaction of 2,6-difluoropyridine with ammonia.
Verwenden
2-Amino-6-fluoropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Synthese

1513-65-1

1597-32-6

The general procedure for the synthesis of 2-amino-6-fluoropyridine from 2,6-difluoropyridine was as follows: 2,6-difluoropyridine (50 g, 434 mmol) was dissolved in ammonium hydroxide solution (200 mL, 28.0-30.0%) in a steel tube and the reaction was heated for 15 hr at 105 °C. Upon completion of the reaction, the mixture was cooled in an ice bath and the precipitate was subsequently collected by filtration. The precipitate was washed with cold water and dried to give 6-fluoro-2-pyridinamine (45.8 g, 94% yield) as a white solid. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 7.53 (m, 1H), 6.36 (dd, 1H), 6.26 (dd, 1H), 4.56 (s, 2H).
Einzelnachweise
[1] Patent: WO2006/76131, 2006, A2. Location in patent: Page/Page column 39-40
[2] Patent: WO2007/27999, 2007, A2. Location in patent: Page/Page column 35
[3] Patent: WO2006/36816, 2006, A2. Location in patent: Page/Page column 59-60
[4] Patent: WO2006/26703, 2006, A2. Location in patent: Page/Page column 64-65
[5] Patent: WO2007/87549, 2007, A2. Location in patent: Page/Page column 44; 59

2-Amino-6-fluoropyridine Upstream-Materialien And Downstream Produkte

2-Amino-6-fluoropyridine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1597-32-6, 2-Amino-6-fluoropyridine Verwandte Suche:

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