Pyridin-2,6-diyldiamin

Bezeichnung:Pyridin-2,6-diyldiamin

CAS-Nr141-86-6

Englisch Name:2,6-Diaminopyridine

CBNumberCB0236195

SummenformelC5H7N3

Molgewicht109.13

MOL-Datei141-86-6.mol

Synonyma

Pyridin-2,6-diyldiamin

Pyridin-2,6-diyldiamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	117-122 °C (lit.)
Siedepunkt	285 °C (lit.)
Dichte	1.7110 (rough estimate)
Brechungsindex	1.5340 (estimate)
Flammpunkt	155°C
storage temp.	Store below +30°C.
Löslichkeit	180g/l
Aggregatzustand	Flakes or Crystalline Powder
pka	6.13±0.24(Predicted)
Farbe	Beige to dark brown-gray
PH	>7 (H2O)
Wasserlöslichkeit	9.9 g/100 mL (20 ºC)
BRN	108513
InChIKey	VHNQIURBCCNWDN-UHFFFAOYSA-N
LogP	0.550 (est)
CAS Datenbank	141-86-6(CAS DataBase Reference)
NIST chemische Informationen	2,6-Pyridinediamine(141-86-6)
EPA chemische Informationen	2,6-Pyridinediamine (141-86-6)

Sicherheit

Kennzeichnung gefährlicher	Xn,T,Xi
R-Sätze:	22-36/37/38-25-20/21
S-Sätze:	26-45-37/39-28A-36
RIDADR	2811
WGK Germany	3
RTECS-Nr.	US7570000
F	9
TSCA	Yes
HazardClass	6.1
PackingGroup	II
HS Code	29333999

Gefahreninformationscode (GHS)

2,6-Diaminopyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
2,6-Diaminopyridine is an important organic reagent with a wide range of uses. It can be used for fluorescence detection, 2,6-Diaminopyridine fluorescence method for the determination of certain aromatic primary amines. It can also be used to prepare 2,6-Diaminopyridine imprinted core-shell nanoparticles. A new method for the detection of diaminopyridine derivatives using molecularly imprinted electrochemical sensors has been established, which has been applied to the detection of 2,6-Diaminopyridine in hair dyes with good sensitivity and selectivity.
Chemische Eigenschaften
Off-white crystal powder/granuale
Verwenden
2,6-Diaminopyridine, used as a pharmaceutical intermediate and a hair dye coupler in oxidation/permanent formulations.
synthetische
In a 600 mL autoclave equipped with a gas entrapment stirrer, a solution of 5 g CuI in 120 g aqueous ammonia (30% NH3 by weight) was added and mixed with 77 g ammonium acetate and 60 g of 2, 6-dichloropyridine. After purging with nitrogen, 24 g of liquid ammonia was added resulting in a pressure of about 150 psi (1.03 MPa). Subsequently, the reaction mixture was heated to 150°C for 8 h under stirring. Throughout the reaction, the pressure decreased from an initial pressure of 680 psi (4.69 MPa) to 450 psi (3.10 MPa). The reaction mixture was allowed to cool to room temperature, and the pressure was brought back to atmospheric pressure. Finally, 2,6-Diaminopyridine was obtained after purification.
Sicherheitsprofil
Poison by intravenous and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Toxicity evaluation
2,6-Diaminopyridine was not mutagenic in Salmonella typhimurium strain TA98 in the presence or absence of nonharman at 200 μg/plate. The mutagenicity of this compound was not enhanced by rodent liver S-9 (Sugimura et al., 1982).
In another study, it was not mutagenic in S. typhimurium strain TA98 without rodent liver S-9. However, it was mutagenic in the presence of rodent liver S-9 (Takahashi & Ono, 1993).
This compound was not mutagenic in S. typhimurium strains TA98, TA100, and TA1535 in the presence or absence of rodent liver S-9 (JETOC, 1997; Takahashi & Ono, 1993)
It was mutagenic in S. typhimurium strain TA1537 in the presence or absence of rodent liver S-9 (JETOC, 1997).
2,6-Diaminopyridine was not mutagenic in Escherichia coli strain WP2 uvrA in the presence or absence of rodent liver S-9 (JETOC, 1997).

2,6-Diaminopyridine Upstream-Materialien And Downstream Produkte

Pyridin-2,6-diyldiamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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