Dihydrocumarin

Bezeichnung:Dihydrocumarin

CAS-Nr119-84-6

Englisch Name:Dihydrocoumarin

CBNumberCB4413174

SummenformelC9H8O2

Molgewicht148.16

MOL-Datei119-84-6.mol

Synonyma

3,4-Dihydrocumarin

Dihydrocumarin

Dihydrocumarin physikalisch-chemischer Eigenschaften

Schmelzpunkt	24-25 °C (lit.)
Siedepunkt	272 °C (lit.)
Dichte	1.169 g/mL at 25 °C (lit.)
Dampfdruck	13.6kPa at 20℃
Brechungsindex	n20/D 1.556(lit.)
FEMA	2381 \| DIHYDROCOUMARIN
Flammpunkt	>230 °F
storage temp.	Sealed in dry,2-8°C
Löslichkeit	Chloroform, Methanol (Sparingly)
Aggregatzustand	Solid
Wichte	1.169
Farbe	Colourless to Off-White
Geruch (Odor)	at 10.00 % in dipropylene glycol. sweet tonka coumarinic coconut herbal cinnamon balsamic
Geruchsart	tonka
Wasserlöslichkeit	insoluble
JECFA Number	1171
BRN	4584
LogP	1.82 at 25℃
CAS Datenbank	119-84-6(CAS DataBase Reference)
NIST chemische Informationen	2H-1-Benzopyran-2-one, 3,4-dihydro-(119-84-6)
EPA chemische Informationen	3,4-Dihydrocoumarin (119-84-6)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	MW5775000
TSCA	Yes
HS Code	29322980
Giftige Stoffe Daten	119-84-6(Hazardous Substances Data)
Toxizität	The acute oral LD₅₀ value in rats was reported as 1.65 g/kg (1.47-1.83 g/ kg) (Moreno, 1972a). The acute dermal LD₅₀ value in rabbits was reported as > 5 g/kg (Moreno, 1972b).

Gefahreninformationscode (GHS)

Dihydrocoumarin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Dihydrocoumarin forms colorless crystals (mp 24°C) with a sweet, herbal odor. Dihydrocoumarin is prepared by hydrogenation of coumarin, for example, in the presence of a Raney nickel catalyst. Another process employs the vapor-phase dehydrogenation of hexahydrocoumarin in the presence of Pd or Pt-Al₂O₃ catalysts . Hexahydrocoumarin is prepared by cyanoethylation of cyclohexanone and hydrolysis of the nitrile group, followed by ring closure to the lactone.
Chemische Eigenschaften
Dihydrocoumarin has an odor similar to coumarin at room temperature or reminiscent of nitrobenzene at higher temperature. It has a burning taste.
Occurrence
Reported found in Melilotus officinalis, from which it may be extracted by water distillation.
Verwenden
Hydrocoumarin can be used as a reagent to prepare splitomicin analogs as inhibitors of Sir2.
Verwenden
Dihydrocoumarin may be used as an analytical reference standard for the determination of the analyte in guaco extracts and pharmaceutical preparations, and various plant extracts by chromatography-based techniques and capillary electrophoresis.
synthetische
Dihydrocoumarin is synthesized by reduction of coumarin under pressure in the presence of nickel at 160 to 200°C or in the presence of Pd-BaSO4 in alcoholic solution.
Definition
ChEBI: A chromanone that is the 3,4-dihydro derivative of coumarin.
Synthesis Reference(s)
Tetrahedron Letters, 37, p. 4555, 1996 DOI: 10.1016/0040-4039(96)00902-1
Allgemeine Beschreibung
Viscous, almost colorless liquid, solidifying in the cold, melting at 23° C. Sp. Gr. 1.19. B.P. 272° C. Slightly soluble in water, soluble in alcohol, miscible with oils.
Sweet-herbaceous, nutlike, haylike odor, usually described as "coumannic" or "tobacco-like".
Air & Water Reaktionen
Solutions of the chemical in water are stable for less than two hours. Insoluble in water.
Reaktivität anzeigen
Hydrocoumarin is a lactone (behaves as an ester). Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Hydrocoumarin may hydrolyze under alkaline or acidic conditions.
Brandgefahr
Hydrocoumarin is combustible.
Biochem/physiol Actions
Taste at 10 ppm

Dihydrocoumarin Upstream-Materialien And Downstream Produkte

Dihydrocumarin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

119-84-6, Dihydrocoumarin Verwandte Suche:

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