1-Benzopyran-2-on Produkt Beschreibung

Coumarin Struktur
91-64-5
  • CAS-Nr.91-64-5
  • Bezeichnung:1-Benzopyran-2-on
  • Englisch Name:Coumarin
  • Synonyma:Cumarin;1-Benzopyran-2-on;1,2-Benzopyron;2H-1-Benzopyran-2-on
    Rattex;CUMARIN;Kumarin;COUMARIN;NSC 8774;ncic07103;COUMARINE;NCI C07103;AKOS 212-75;COUMARIN(P)
  • CBNumber:CB3112168
  • Summenformel:C9H6O2
  • Molgewicht:146.14
  • MOL-Datei:91-64-5.mol
1-Benzopyran-2-on physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :68-73 °C(lit.)
  • Siedepunkt: :298 °C(lit.)
  • Dichte :0.935
  • Dampfdruck :0.01 mm Hg ( 47 °C)
  • Brechungsindex :1.5100 (estimate)
  • Flammpunkt: :162 °C
  • storage temp.  :Refrigerator
  • Löslichkeit :1.7g/l
  • Aggregatzustand :Crystals or Crystalline Powder
  • Farbe :White
  • Säure-Base-Indikators(pH-Indikatoren) :Non' uorescence (9.5) to light green ' uorescence (10.5)
  • Wasserlöslichkeit :1.7 g/L (20 ºC)
  • maximale Wellenlänge (λmax) :275nm
  • Merck  :14,2562
  • BRN  :383644
  • Major Application :color filter, organic electroluminescent devices, liquid crystal displays, field emission displays, inks, nickel plating, detergents, deodorant for shoes, petroleum products, cigarettes, personal care products, cosmetics, sunscreen cream, perfumes, nucleic acid sequencing, antiinflammatory agent, treatment of cancer, neurotransmission disorders, bleeding disorders, cerebrovascular disease, thrombosis, hemorrhoids, rheumatic disease, arthritic disease, epilepsy, vaginitis, painkiller, teeth whitening agent, skin whitening agent, wound healing promoter
  • InChIKey :ZYGHJZDHTFUPRJ-UHFFFAOYSA-N
  • CAS Datenbank :91-64-5(CAS DataBase Reference)
  • NIST chemische Informationen :Coumarin(91-64-5)
  • EPA chemische Informationen :2H-1-Benzopyran- 2-one(91-64-5)
Sicherheit

Coumarin Chemische Eigenschaften,Einsatz,Produktion Methoden

  • ERSCHEINUNGSBILD FARBLOSE FLOCKEN MIT CHARAKTERISTISCHEM GERUCH.
  • ARBEITSPLATZGRENZWERTE TLV nicht festgelegt.
    MAK nicht festgelegt.
  • AUFNAHMEWEGE Aufnahme in den Körper durch Inhalation des Aerosols, über die Haut und durch Verschlucken.
  • INHALATIONSGEFAHREN Verdampfen bei 20°C vernachlässigbar; eine belästigende Partikelkonzentration in der Luft kann jedoch schnell erreicht werden.
  • WIRKUNGEN BEI KURZZEITEXPOSITION WIRKUNGEN BEI KURZZEITEXPOSITION:
    Die Substanz reizt die Haut.
  • WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION Möglicherweise krebserzeugend für den Menschen.
  • LECKAGE Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, P2-Filter für schädliche Partikel.
  • R-Sätze Betriebsanweisung: R22:Gesundheitsschädlich beim Verschlucken.
    R40:Verdacht auf krebserzeugende Wirkung.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
    R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
    R43:Sensibilisierung durch Hautkontakt möglich.
  • S-Sätze Betriebsanweisung: S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
    S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  • Chemische Eigenschaften WHITE CRYSTALS OR CRYSTALLINE POWDER
  • Chemische Eigenschaften Coumarin occurs widely in nature and determines, for example, the odor of woodruff. It forms white crystals (mp 70.6°C) with a hay-like, spicy odor. When treated with dilute alkali, coumarin is hydrolyzed to the corresponding coumarinic acid salt [(Z)-2-hydroxycinnamic acid]. Heating with concentrated alkali or with sodium ethanolate in ethanol results in the formation of o-coumaric acid salts [(E)-2-hydroxycinnamic acid]. 3,4-Dihydrocoumarin is obtained by catalytic hydrogenation, for example, with Raney nickel as a catalyst; octahydrocoumarin is obtained if hydrogenation is carried out at high temperature (200–250°C).
  • Chemische Eigenschaften Coumarin has a sweet, fresh, hay-like, odor similar to vanilla seeds, and a burning taste with bitter undertone and nutlike flavor on dilution.
  • Verwenden coumarin is considered a blood thinner, it can also increase blood flow. Some sources cite anti-oxidant capacities, as well. It is a specific plant constituent and is what creates the fragrance of freshly mowed hay. Coumarin is found in such plants as cherries, lavender, licorice, and sweet clover.
  • Verwenden Pharmaceutic aid (flavor). Found in tonka beans, levender oil, woodruff, sweet clover.
  • Verwenden antineoplastic, antiinflammatory, antihyperglycaemic
  • Definition ChEBI: A chromenone having the keto group located at the 2-position.
  • synthetische Coumarin is currently produced by Perkin synthesis from salicylaldehyde. In the presence of sodium acetate, salicylaldehyde reacts with acetic anhydride to produce coumarin and acetic acid. The reaction is carried out in the liquid phase at elevated temperature.
    A process for the production of coumarin from hexahydrocoumarin by dehydrogenation has also been elaborated.
    Since the odor of coumarin is relatively weak, strong-smelling by-products (e.g., vinylphenol) must be removed. Many purification methods have been reported and patented.
  • Definition A colorless crystalline compound with a pleasant odor, used in making perfumes. On hydrolysis with sodium hydroxide it forms coumarinic acid.
  • Aroma threshold values Detection at 34 to 50 ppb; recognition, 250 ppb
  • Allgemeine Beschreibung Colorless crystals, flakes or colorless to white powder with a pleasant fragrant vanilla odor and a bitter aromatic burning taste.
  • Air & Water Reaktionen Insoluble in water.
  • Reaktivität anzeigen Coumarin is sensitive to exposure to light. Coumarin is also sensitive to heat. Coumarin is incompatible with strong acids, strong bases and oxidizers. Coumarin is hydrolyzed by hot concentrated alkalis. Coumarin can be halogenated, nitrated and hydrogenated (in the presence of catalysts).
  • Hazard Toxic by ingestion; carcinogenic. Use in food products prohibited (FDA). Questionable carcinogen.
  • Health Hazard SYMPTOMS: Exposure to Coumarin may cause narcosis. It may also cause irritation and liver damage.
  • Brandgefahr Coumarin is combustible.
  • Kontakt-Allergie Coumarin is an aromatic lactone naturally occurring in Tonka beans and other plants. As a fragrance allergen, it has to be mentioned by name in cosmetics within the EU
  • Sicherheitsprofil Poison by ingestion, intraperitoneal, and subcutaneous routes. Questionable carcinogen with experimental tumorigenic data. Experimental teratogenic effects. Mutation data reported. Combustible when exposed to heat or flame. When heated to decomposition it emits acrid smoke and fumes. See also KETONES and ANHYDRIDES.
  • Chemical Synthesis May be extracted from tonka beans; from salicylaldehyde and acetic anhydride in the presence of sodium acetate; also from o-cresol and carbonyl chloride followed by chlorination of the carbonate and fusion with a mixture of alkali acetate, acetic anhydride and a catalyst.
  • läuterung methode Coumarin crystallises from ethanol or water and sublimes in vacuo at 43o [Srinivasan & deLevie J Phys Chem 91 2904 1987]. [Beilstein 17/10 V 143.]
Coumarin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-Benzopyran-2-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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91-64-5, Coumarin Verwandte Suche:
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  • TIMTEC-BB SBB000094
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  • coumarin,2-oxo-2H-1-benzopyran,coumaricacid,coumarine
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  • CUMARIN
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  • COUMARIN, CHINESE
  • COUMARINIC ANHYDRIDE
  • CIS-O-COUMARINIC ACID LACTONE
  • CHROMEN-2-ONE
  • 2H-1-Benzopyran, 2-oxo-
  • 2h-benzo(b)pyran-2-one
  • 2H-Benzo[b]pyran-2-one
  • 2H-Chromen-2-one
  • 2-Oxo-1,2-benzopyran
  • 2-oxo-2h-1-benzopyra
  • 2-Propenoic acid, 3-(2-hydroxyphenyl)-, delta-lactone
  • 2-propenoicacid,3-(2-hydroxyphenyl)-delta-lactone
  • 3-(2-hydroxyphenyl)-2-propenoicacidelta-lactone
  • 5,6-benzo-alpha-pyrone
  • Benzo-alpha-pyrone
  • Cinnamic acid, o-hydroxy-, delta-lactone
  • cis-o-coumaricacidanhydride
  • coumariniclactone
  • Kumarin
  • NCI C07103
  • ncic07103
  • o-coumaricacidlactone
  • o-Hydroxycinnamic lactone
  • o-hydroxy-cinnamicacidelta-lactone
  • o-hydroxycinnamiclactone
  • o-Hydroxyzimtsaure-lacton
  • Rattex
  • cis-O-Coumarinic acid lactoneCoumarinic acid lactone Tonka bean camphor
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