trans-4-[[(2-Amino-3,5-dibromphenyl)methyl]amino]cyclohexan-1-olhydrochlorid

Bezeichnung:trans-4-[[(2-Amino-3,5-dibromphenyl)methyl]amino]cyclohexan-1-olhydrochlorid

CAS-Nr23828-92-4

Englisch Name:Ambroxol hydrochloride

CBNumberCB4304139

SummenformelC13H19Br2ClN2O

Molgewicht414.56

MOL-Datei23828-92-4.mol

Synonyma

trans-4-[[(2-Amino-3,5-dibromphenyl)methyl]amino]cyclohexan-1-olhydrochlorid

trans-4-[[(2-Amino-3,5-dibromphenyl)methyl]amino]cyclohexan-1-olhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	233-234.5°C
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	Sparingly soluble in water, soluble in methanol, practically insoluble in methylene chloride.
Aggregatzustand	Solid
Farbe	White to Off-White
PH	pH(10g/l, 25℃) : 4.0～6.0
Wasserlöslichkeit	Slightly soluble in water (~5 mg/ml) or ethanol (~5 mg/ml).
Merck	14,386
InChI	InChI=1/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-;
InChIKey	QNVKOSLOVOTXKF-PFWPSKEQSA-N
SMILES	[C@@H]1(O)CC[C@@H](NCC2=CC(Br)=CC(Br)=C2N)CC1.[H]Cl \|&1:0,4,r\|
CAS Datenbank	23828-92-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	36
WGK Germany	3
RTECS-Nr.	GV8423000
HS Code	29221980
Toxizität	LD50 in mice, rats (mg/kg): 268, 380 i.p.; 2720, 13400 orally (Püschmann, Engelhorn)

Gefahreninformationscode (GHS)

Ambroxol hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White Crystalline Powder
Verwenden
Ambroxol hydrochloride is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy. Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion. It enhances pulmonary surfactant production and stimulates ciliary activity.
Definition
ChEBI: Ambroxol hydrochloride is an aromatic amine. it is a metabolite of bromhexine that stimulates mucociliary action and clears the air passages in the respiratory tract. it is usually administered as the hydrochloride.
Indications
Ambroxol Hydrochloride is a bronchosecretolytic drug. It is indicated as “secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe freely and deeply.
Biologische Aktivität
Sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC 50 values for tonic block are 35.2 and 111.5 μ M respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells.
Mode of action
Ambroxol is the active metabolite of bromhexine. Ambroxol causes an increase in secretion in the respiratory tract. It promotes surfactant production and stimulates ciliary activity. These effects assist the flow of mucus and its removal (mucociliary clearance). An improvement in mucociliary clearance was demonstrated in clinical pharmacological studies. The increase in secretion and mucociliary clearance facilitate expectoration and reduce the cough. In in vitro studies ambroxol showed a significant reduction in cytokine release, both in the blood and in mononuclear and polynuclear cells. The clinical relevance of these findings is unclear.

Ambroxol hydrochloride Upstream-Materialien And Downstream Produkte

trans-4-[[(2-Amino-3,5-dibromphenyl)methyl]amino]cyclohexan-1-olhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

23828-92-4, Ambroxol hydrochloride Verwandte Suche:

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