2-Amino-5-phenyl-4(5H)-oxazolon

Bezeichnung:2-Amino-5-phenyl-4(5H)-oxazolon

CAS-Nr2152-34-3

Englisch Name:Pemoline

CBNumberCB4180793

SummenformelC9H8N2O2

Molgewicht176.17

MOL-Datei2152-34-3.mol

Synonyma

Pemolin

2-Amino-5-phenyl-4(5H)-oxazolon

2-Amino-5-phenyl-4(5H)-oxazolon physikalisch-chemischer Eigenschaften

Schmelzpunkt	255-256°C
Siedepunkt	307.77°C (rough estimate)
Dichte	1.2662 (rough estimate)
Brechungsindex	1.5570 (estimate)
storage temp.	Store at RT
Löslichkeit	DMSO: soluble28mg/mL
pka	pKa 10.5 (Uncertain)
Aggregatzustand	solid
Farbe	white
CAS Datenbank	2152-34-3(CAS DataBase Reference)
NIST chemische Informationen	4(5H)-oxazolone, 2-amino-5-phenyl-(2152-34-3)

Sicherheit

Kennzeichnung gefährlicher	Xn,C,F,T
R-Sätze:	22-34-11-20/21/22
S-Sätze:	16-26-36/37/39-45-36/37-36
WGK Germany	3
RTECS-Nr.	PB8750000
Giftige Stoffe Daten	2152-34-3(Hazardous Substances Data)
Toxizität	LD50 orally in rats: 500 mg/kg (Schafer)

Gefahreninformationscode (GHS)

Pemoline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R34:Verursacht Verätzungen.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White Solid
Originator
Deltamine,Aron,France,1960
Verwenden
A CNS stimulant. Controlled Substance
Definition
ChEBI: A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.
Manufacturing Process
It is preferably prepared by reacting mandelic acid ethyl ester with guanidine in boiling alcoholic solution whereby it is obtained as difficultly soluble precipitate with a yield of 90%.
This compound is a white, crystalline compound melting at 256°-257°C with decomposition. It is readily soluble in concentrated aqueous alkali hydroxide solutions and in concentrated aqueous mineral acids.
Trademarks
Cylert (Abbott).
Therapeutic Function
Psychostimulant
Weltgesundheitsorganisation (WHO)
Pemoline was introduced in 1975 for the treatment of attentiondeficit disorder. Because of its central stimulating effects it has also been used in weight control in combination with anorectic agents, laxatives.
Allgemeine Beschreibung
Pemoline, 2-amino-5-phenyl-4(5H)-oxazolone (Cylert), hasa unique structure.
The compound is described as having an overall effect onthe CNS like that of methylphenidate. Pemoline requires 3to 4 weeks of administration, however, to take effect. A partialexplanation for the delayed effect may be that one of theactions of the agent, as observed in rats, is to increase therate of synthesis of DA.
Biologische Aktivität
Long-acting central stimulant that induces self-injurious behavior in rats. Acts as an indirect monoamine agonist.

Pemoline Upstream-Materialien And Downstream Produkte

2152-34-3, Pemoline Verwandte Suche:

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