Lercanidipine

Bezeichnung:Lercanidipine

CAS-Nr100427-26-7

Englisch Name:Lercanidipine

CBNumberCB4133658

SummenformelC36H41N3O6

Molgewicht611.73

MOL-Datei100427-26-7.mol

Lercanidipine physikalisch-chemischer Eigenschaften

Schmelzpunkt	118-120°C
Siedepunkt	712.5±60.0 °C(Predicted)
Dichte	1.177±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
Löslichkeit	Soluble in DMSO
Aggregatzustand	Powder
pka	8.66±0.50(Predicted)
Farbe	Light yellow to yellow
CAS Datenbank	100427-26-7(CAS DataBase Reference)

Gefahreninformationscode (GHS)

Lercanidipine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Lerdip was launched in the Netherlands for hypertension. It is prepared in four steps, the last of which is a Hantsch reaction of 1-[(3,3-diphenyl)-N-methylpropylamino]- 2-methyl-2-propyl-2-(3-nitrobenzylidene)acetoacetate with methyl 3-aminocrotonate. This compound was designed to be very lipophilic which imparts the drug with a gradual onset and a long duration of action as a result of prolonged exposure to receptors by partitioning into membranes. It is an antagonist of L-type calcium channels with no activity in smooth muscle cells, is tissue selective, lacks any myocardial contractility impairment, has no neuroendocrine activation, and has negligible affinity for neurotransmitter receptors such as α₁- and α₂-adrenergic receptors. While sold as a racemate, the calcium channel activity is found in the (S)- isomer with the (R)-isomer being 2-orders of magnitude less active. It has an increased cardiac contractility index which is much more than Nitrendipine or nifedipine. The good selectivity causes a reduction in blood pressure with no negative inotropic effects.
Originator
Recordati (Italy)
Verwenden
Antihypertensive compound; calcium channel blocker.
Definition
ChEBI: Lercanidipine is a diarylmethane.
Trademarks
Cardiovasc (Recor dati, Italy); Carmen (Recordati, Italy); Corifeo (Recordati, Italy); Lercadip (Recordati, Italy); Lercan (Recordati, Italy); Lercapin (Recordati, Italy); Lercaton (Recordati, Italy); Lerkamen (Recordati, Italy); Lerzam (Recordati, Italy); Renovia (Recordati, Italy); Vasodip (Recordati, Italy); Zandip (Recordati, Italy); Zanicor (Recordati, Italy).

Lercanidipine Upstream-Materialien And Downstream Produkte

Lercanidipine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

100427-26-7, Lercanidipine Verwandte Suche:

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