Nitrendipin

Bezeichnung:Nitrendipin

CAS-Nr39562-70-4

Englisch Name:Nitrendipine

CBNumberCB2395104

SummenformelC18H20N2O6

Molgewicht360.36

MOL-Datei39562-70-4.mol

Synonyma

Nitrendipin

Nitrendipin physikalisch-chemischer Eigenschaften

Schmelzpunkt	1580C
Siedepunkt	492.4°C (rough estimate)
Dichte	1.3595 (rough estimate)
Brechungsindex	1.5700 (estimate)
storage temp.	2-8°C
Löslichkeit	methanol: 15 mg/mL
Aggregatzustand	powder
pka	2.79±0.70(Predicted)
Farbe	yellow to green
Wasserlöslichkeit	Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water.
Stabilität	Stable for 1 year from date of purchase as supplied. Protect from light. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
CAS Datenbank	39562-70-4(CAS DataBase Reference)
NIST chemische Informationen	Nitrendipine(39562-70-4)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22
S-Sätze:	36
WGK Germany	1
RTECS-Nr.	US5653000
Toxizität	LD50 in mice, rats (mg/kg): 39, 12.6 i.v.; 2540, >10000 orally (Hoffmann)

Gefahreninformationscode (GHS)

Nitrendipine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Nitrendipine is a vasodilating, dihydropyridine calcium antagonist. Its prolonged therapeutic effect in comparison to nifedipine makes it useful in the once to twice daily treatment of hypertension.
Chemische Eigenschaften
Crystalline Solid
Originator
Bayer (W. Germany)
Verwenden
Antihypertensive;Calcium channel blocker
Verwenden
Nitrendipine modulates NMDA receptor channel function in mammalian neurons. Nitrendipine has been shown to inhibit neutrophil adhesion to vascular endothelium. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.
Verwenden
Nitrendipine is a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.
Definition
ChEBI: A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in t e treatment of hypertension.
Trademarks
Baypress (Bayer);BAYOTENSIN.
Allgemeine Beschreibung
Nitrendipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ethylester (Baypress), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissue andserves as an effective vasodilator. The drug is used in thetreatment of mild-to-moderate essential hypertension.
Biologische Aktivität
L-type calcium channel blocker.
Biochem/physiol Actions
Ca2+ channel blocker; anti-hypertensive.
Lager
Store at RT
Einzelnachweise
1) Meyer et al., (1981), (Synthesis and comparative pharmacological studies of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylates with non-identical ester functions); Arzneimittelforschung 31 407 2) Stoepel et al., (1981), Pharmacological studies of the antihypertensive effect of nitrendipine; Arzneimittelforschung 31 2056

Nitrendipine Upstream-Materialien And Downstream Produkte

Nitrendipin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

39562-70-4, Nitrendipine Verwandte Suche:

Send Inquriy