Propiverine hydrochloride

Bezeichnung:Propiverine hydrochloride

CAS-Nr54556-98-8

Englisch Name:Propiverine hydrochloride

CBNumberCB3855472

SummenformelC23H30ClNO3

Molgewicht403.94

MOL-Datei54556-98-8.mol

Propiverine hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	224-226°C
storage temp.	2-8°C
Löslichkeit	H2O: soluble5mg/mL, clear (warmed)
Aggregatzustand	powder
Farbe	white to beige
CAS Datenbank	54556-98-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	37/38-41
S-Sätze:	26-39
WGK Germany	3
RTECS-Nr.	AH3297000
Toxizität	LD50 in male, female mice, male, female rats (mg/kg): 36, 36, 22, 25 i.v.; 223, 283, 1632, 1411 s.c.; 410, 323, 1000, 1092 orally (Yamashita)

Gefahreninformationscode (GHS)

Propiverine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Propiverine hydrochloride is a new urological agent developed for pollakuria and aconuresis. It appears to exhibit anticholinergic properties and in animal experiments inhibited KCl induced contractions in the bladder and ileum.
Chemische Eigenschaften
Off-White Solid
Originator
Apogepha (Germany)
Verwenden
Propiverine is used in treatment of urinary incontinence. Propiverine is an anticholinergic.
Definition
ChEBI: Propiverine hydrochloride is a diarylmethane.
Trademarks
Mictonorm; Mictonetten
Allgemeine Beschreibung
Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles. Propiverine hydrochloride has a half-life of 20 hours.
Biochem/physiol Actions
Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity.
Clinical Use

Treatment of urinary frequency, urgency and incontinence
Neurogenic bladder instability
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide.
Stoffwechsel
Propiverine is extensively metabolised by intestinal and hepatic enzymes. Four metabolites were identified in urine; two of them are pharmacologically active and may contribute to the therapeutic efficacy.
Propiverine and its metabolites are excreted in the urine, bile and faeces.

Propiverine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

54556-98-8, Propiverine hydrochloride Verwandte Suche:

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