2'-Hydroxychalkon

Bezeichnung:2'-Hydroxychalkon

CAS-Nr1214-47-7

Englisch Name:2'-Hydroxychalcone

CBNumberCB3771305

SummenformelC15H12O2

Molgewicht224.25

MOL-Datei1214-47-7.mol

Synonyma

2'-Hydroxychalkon

2'-Hydroxychalkon physikalisch-chemischer Eigenschaften

Schmelzpunkt	86-88 °C(lit.)
Siedepunkt	396.6±42.0 °C(Predicted)
Dichte	1.191±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	Store below +30°C.
pka	7.77±0.30(Predicted)
BRN	976324
LogP	4.000 (est)
CAS Datenbank	1214-47-7(CAS DataBase Reference)
EPA chemische Informationen	2-Propen-1-one, 1-(2-hydroxyphenyl)-3-phenyl- (1214-47-7)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	UD5579400
F	8
Selbstentzündungstemperatur	280 °C
TSCA	Yes
HS Code	29145090
Toxizität	mammal (species unspecified),LD50,unreported,620mg/kg (620mg/kg),Pharmaceutical Chemistry Journal Vol. 20, Pg. 406, 1986.

Gefahreninformationscode (GHS)

2'-Hydroxychalcone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Yellow needle-like crystals (ethanol). Melting point 88-89°C.
Verwenden
2'-Hydroxychalcone can be used as intermediates in drug synthesis, such as the preparation of flavonol compounds. Flavonols are widely distributed in nature as secondary metabolites in living organisms, and they have a wide variety of physiological activities, mainly in the cardiovascular system, antiviral, anti-inflammatory and antitumor effects.
synthetische
Synthesis of 2'-hydroxychalcone: add 30 ml of 20% (V/V) ethanol and (11.06 mmol) sodium hydroxide in a 50 mL single mouth flask, stir for 0.5 h at room temperature and then add substituted 2-Hydroxyacetophenone (1.66 mmol) and benzaldehyde (1.66 mmol), stir for 18 h at room temperature, TLC monitoring until the new point produces raw material point no longer changes, stop the reaction Then the reaction was poured into water, stirred while adjusting the pH value to acidic with 6 mol/L hydrochloric acid, the reaction was filtered, the filter cake was obtained, rinsed twice with pure water, and 2'-hydroxychalcone was obtained by silica gel column chromatography [V(petroleum ether):V(ethyl acetate) = 5:1] in 85% yield.
Definition
ChEBI: 2'-hydroxychalcone is a member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'. It has a role as an anti-inflammatory agent. It is a member of phenols and a member of chalcones. It derives from a trans-chalcone.

2'-Hydroxychalcone Upstream-Materialien And Downstream Produkte

2'-Hydroxychalkon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1214-47-7, 2'-Hydroxychalcone Verwandte Suche:

Send Inquriy