3,5,7-Trihydroxy-2-phenyl-4-benzopyron

Bezeichnung:3,5,7-Trihydroxy-2-phenyl-4-benzopyron

CAS-Nr548-83-4

Englisch Name:Galangin

CBNumberCB8413460

SummenformelC15H10O5

Molgewicht270.24

MOL-Datei548-83-4.mol

Synonyma

3,5,7-Trihydroxy-2-phenyl-4-benzopyron

3,5,7-Trihydroxy-2-phenyl-4-benzopyron physikalisch-chemischer Eigenschaften

Schmelzpunkt	214-215 °C(lit.)
Siedepunkt	333.35°C (rough estimate)
Dichte	1.2319 (rough estimate)
Brechungsindex	1.6000 (estimate)
storage temp.	room temp
Löslichkeit	Acetone (Slightly), Ethyl Acetate (Slightly)
Aggregatzustand	Solid
pka	6.32±0.40(Predicted)
Farbe	Light Yellow to Yellow
Merck	14,4339
BRN	272179
InChIKey	VCCRNZQBSJXYJD-UHFFFAOYSA-N
LogP	3.322 (est)
CAS Datenbank	548-83-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-37/39
WGK Germany	3
RTECS-Nr.	LK9275500
F	10
HS Code	29329990

Gefahreninformationscode (GHS)

Galangin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Galangin is a flavonoid naturally found in herbs used in traditional medicine. Like many flavonoids, it has potent antioxidant properties. It also has anti-inflammatory actions related to suppression of signaling through NF-κB in mice. Galangin acts as an antagonist of the aryl hydrocarbon receptor, inducing apoptosis in cancer cells. It also inhibits cytochrome P450 isoform 1A1 with an IC₅₀ value of less than 1 μM.
Chemische Eigenschaften
Yellow powder
Verwenden
CYP1A1 inhibitor, vasodilator
Verwenden
Galangin is a flavanoid found in Alpinia officinarum, galangal rhizome (Alpinia galanga) and in propolis. Galangin has been show to inhibit proliferation of estrogen receptor-positive MCF-7 human breast cancer cells as well as delay of mammary tumorigenesis.
Definition
ChEBI: A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively.
Allgemeine Beschreibung
Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.
Biochem/physiol Actions
Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory and anti-obesity properties. In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis. Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.
Anticancer Research
Galangin is a flavonol that is derived from Alpinia officinarum, a plant from the gingerfamily, grown in Southeast Asia. The extract from the rhizome suppresses cellproliferation of hepatocellular carcinoma cells (Su et al. 2013). ER stress is inducedby galangin as is evident by rise in concentration of cytosolic Ca2+ and other UPRtarget genes like CHOP, GRP 78 and GRP 94. The ER is a major storage site forintracellular calcium. Normal functioning of ER chaperones is disrupted by calciumexhaustion in ER which produces ER stress and hence activation of UPR (Hotamisligil2010; Mekahli et al. 2011). CHOP and 4-polybutyric acid siRNA, well-known ERstress inhibitor, substantially blocked stress induced by galangin in the HCC cell line.To sum up, ER stress is upregulated by galangin, inhibiting cancer cell proliferation,and galangin can prove to be an effective anticancer agent (Su et al. 2013).

Galangin Upstream-Materialien And Downstream Produkte

3,5,7-Trihydroxy-2-phenyl-4-benzopyron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

548-83-4, Galangin Verwandte Suche:

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