2',3,4',5,7-Pentahydroxyflavon

Bezeichnung:2',3,4',5,7-Pentahydroxyflavon

CAS-Nr480-16-0

Englisch Name:MORIN

CBNumberCB0316037

SummenformelC15H10O7

Molgewicht302.24

MOL-Datei480-16-0.mol

Synonyma

2',3,4',5,7-Pentahydroxyflavon

2',3,4',5,7-Pentahydroxyflavon physikalisch-chemischer Eigenschaften

Schmelzpunkt	299-300 °C (dec.)(lit.)
Siedepunkt	363.28°C (rough estimate)
Dichte	1.3616 (rough estimate)
Brechungsindex	1.4790 (estimate)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Löslichkeit	methanol: 50 mg/mL
Aggregatzustand	powder
Colour Index	75660
pka	6.30±0.40(Predicted)
Farbe	yellow
Wasserlöslichkeit	0.25g/L(20 ºC)
Merck	6269
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	YXOLAZRVSSWPPT-UHFFFAOYSA-N
LogP	1.27-1.54 at 37℃ and pH7.4
CAS Datenbank	480-16-0(CAS DataBase Reference)
EPA chemische Informationen	Morin (480-16-0)

Sicherheit

Kennzeichnung gefährlicher	Xi,T
R-Sätze:	36/37/38-25
S-Sätze:	26-36-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
RTECS-Nr.	LK8749000
F	8-10-23
HS Code	29329990
Toxizität	LD50 intraperitoneal in mouse: 555mg/kg

Gefahreninformationscode (GHS)

MORIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
yellow to brown powder
Verwenden
Morin is a natural pentahydroxyflavonol with antioxidant activity. It reduces CD36 expression and oxLDL uptake in U937-derived macrophages, inhibits PIM-1 kinase in vitro (IC50 = 2.7 μM), and reduces the activity of cytochrome P450 isoform 3A4 in liver microsomes. Through these and other actions, morin has anti-oxidant, anti-inflammatory, and other actions in animal models.[Cayman Chemical]
Verwenden
P450 and ATPase inhibitor
Verwenden
Morin is a polyphenolic flavonoid with radical scavenging ability. In addition it maintains the potential for suppression of lipopolysaccharide-induced neuroinflammation.
Definition
ChEBI: A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.
Sicherheitsprofil
Moderately toxic by intraperitoneal route. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
läuterung methode
Stir morin at room temperature with ten times its weight of absolute EtOH, then leave overnight to settle. Filter it off, and evaporate under a heat lamp to one-tenth its volume. An equal volume of water is added, and the precipitated morin is filtered off, dissolved in the minimum amount of EtOH and again precipitated with an equal volume of water. The precipitate is filtered off, washed with water and dried at 110o for 1hour (yield ca 2.5%.). [Perkins & Kalkwarf Anal Chem 28 1989 1956.] It complexes with W and Zr. [Beilstein 18 H 239, 18 III/IV 3468, 18/5 V 492.]

2',3,4',5,7-Pentahydroxyflavon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

480-16-0, MORIN Verwandte Suche:

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