2-Hydroxychalkon

Bezeichnung:2-Hydroxychalkon

CAS-Nr644-78-0

Englisch Name:2-Hydroxychalcone

CBNumberCB7100356

SummenformelC15H12O2

Molgewicht224.25

MOL-Datei644-78-0.mol

Synonyma

2-Hydroxychalkon

2-Hydroxychalkon physikalisch-chemischer Eigenschaften

Schmelzpunkt	144-150 °C(lit.)
Siedepunkt	396.3±34.0 °C(Predicted)
Dichte	1.191±0.06 g/cm3(Predicted)
pka	9.26±0.35(Predicted)
Aggregatzustand	powder
Farbe	Yellow
BRN	2049134
CAS Datenbank	644-78-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
HS Code	29147000

Gefahreninformationscode (GHS)

2-Hydroxychalcone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. It is also capable of inducing apoptosis by downregulating Bcl-2 levels and inhibiting the activation of NF-kB.
Synthese
A synthesis of 2-Hydroxychalcone was conducted using acetophenone and o-hydroxybenzaldehyde as starting materials. The reaction was catalyzed by potassium hydroxide and ethanol was used as the solvent.
in vitro
2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells.
2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner.
Einzelnachweise
[1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. DOI:10.1016/j.cbi.2013.03.012
[2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. DOI:10.1124/MOL.58.3.526
[3]. Sonochemical Synthesis of 2’-Hydroxy-Chalcone Derivatives with Potential Anti-Oomycete Activity doi: 10.3390/antibiotics9090576

2-Hydroxychalcone Upstream-Materialien And Downstream Produkte

2-Hydroxychalkon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

644-78-0, 2-Hydroxychalcone Verwandte Suche:

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