Propafenone Hydrochloride

Bezeichnung:Propafenone Hydrochloride

CAS-Nr34183-22-7

Englisch Name:Propafenone Hydrochloride

CBNumberCB1311105

SummenformelC21H28ClNO3

Molgewicht377.9

MOL-Datei34183-22-7.mol

Synonyma

1-[2-[2-Hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-onhydrochlorid

Propafenone Hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	165-1670C
storage temp.	2-8°C
Löslichkeit	Slightly soluble in cold water, soluble in methanol and in hot water, practically insoluble in ethanol (96 per cent).
Farbe	White to Off-White
maximale Wellenlänge (λmax)	303nm(MeOH)(lit.)
Merck	14,7794
CAS Datenbank	34183-22-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T,Xn
R-Sätze:	46-22
S-Sätze:	53-36/37/39-45
WGK Germany	3
RTECS-Nr.	UH2833000
HS Code	2922504500
Toxizität	LD50 in rats (mg/kg): 18.8 i.v.; 700 orally (Hapke, Prigge)

Gefahreninformationscode (GHS)

Propafenone Hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R46:Kann vererbbare Schäden verursachen.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Propafenone hydrochloride is a class I anti-arrhythmic agent with basic local anaesthetic and membrane-stabilizing properties. Some P-adrenergic blocking action has also been described. Propafenone decreases the depolarization velocity and slows conduction in the His-Purkinje system with resultant increase in the PR interval and the QRS complex. Propafenone is used in the treatment of paroxysmal supraventricular tachycardias and ventricular arrhythmias.
Propafenone should not be used in uncontrolled cardiac failure, severe obstructive pulmonary disease or marked hypotension. Propafenone may worsen myasthenia gravis.
Chemische Eigenschaften
White Solid
Verwenden
Propafenone hydrochloride is a class IC antiarrhythmic agent used for the management of severe ventricular and supraventricular arrhythmias. It has beta-blocking and weak calcium channel blocking properties, as well as some negative inotropic activity. Propafenone is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm.
Verwenden
Sodium channel blocker. Antiarrhythmic (class IC)
Definition
ChEBI: Propafenone hydrochloride is a hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It contains a propafenone(1+).
Trademarks
Rythmol (Reliant).
Pharmakokinetik
Propafenone hydrochloride (Rythmol(R)) is similar in action to flecainide. It reduces the fast inward sodium current in Purkinje fibres and to a lesser extent in myocardial fibres. Unlike other class l drugs, propafenone has mild B-blocking effects. This may contribute to its overall effects on the conduction system. lt is also believed to have calcium channel-blocking effects, which may contribute to its mild negative inotropic effects.
Clinical Use
Anti-arrhythmic agent:
Ventricular arrhythmias
Paroxysmal supraventricular tachyarrhythmias, (including paroxysmal atrial flutter or fibrillation, and paroxysmal re-entrant tachycardias involving the AV node or accessory pathway) where standard therapy has failed or is unsuitable
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased myocardial depression with other anti-arrhythmics.
Antibacterials: increased metabolism with rifampicin (reduced effect).
Anticoagulants: enhanced anticoagulant effect of coumarins.
Antidepressants: increased risk of arrhythmias with tricyclics; metabolism of propafenone possibly inhibited by paroxetine (increased risk of toxicity).
Antihistamines: increased risk of ventricular arrhythmias with mizolastine - avoid.
Antipsychotics: increased risk of ventricular arrhythmias with antipsychotics that prolong the QT interval.
Antivirals: concentration of propafenone increased by saquinavir and ritonavir and possibly by fosamprenavir, increased risk of ventricular arrhythmias - avoid; use with caution with telaprevir.
Beta-blockers: increased myocardial depression; increased concentration of metoprolol and propranolol.
Cardiac glycosides: increased digoxin concentration - halve digoxin dose.
Ciclosporin: possibly increased ciclosporin concentration.
Ulcer-healing drugs: levels increased by cimetidine.
Stoffwechsel
Propafenone is hepatically metabolised mainly by CYP2D6 isoenzyme but also to a small extent by CYP1A2 and CYP3A4. This forms 2 active metabolites, 5-hydroxypropafenone and N-depropylpropafenone and some inactive ones. Propafenone and its metabolites also undergo glucuronidation. The extent of metabolism is genetically determined.
Propafenone is excreted in the urine and faeces mainly in the form of conjugated metabolites.

Propafenone Hydrochloride Upstream-Materialien And Downstream Produkte

Propafenone Hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

34183-22-7, Propafenone Hydrochloride Verwandte Suche:

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