Phenoxyessigsure

Bezeichnung:Phenoxyessigsure

CAS-Nr122-59-8

Englisch Name:Phenoxyacetic acid

CBNumberCB3485839

SummenformelC8H8O3

Molgewicht152.15

MOL-Datei122-59-8.mol

Synonyma

Phenoxyessigsure

Phenoxyessigsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	98-100 °C (lit.)
Siedepunkt	285 °C
Dichte	1.2143 (rough estimate)
Brechungsindex	1.4447 (estimate)
FEMA	2872 \| PHENOXYACETIC ACID
Flammpunkt	165 °C
storage temp.	Store below +30°C.
Löslichkeit	ethanol: soluble10%, clear, colorless
Aggregatzustand	Granular Powder, Granules, or Prills
pka	3.17(at 25℃)
Farbe	White
Geruch (Odor)	at 1.00 % in propylene glycol. sour sweet
Geruchsart	honey
Wasserlöslichkeit	0.1-0.5 g/100 mL at 17 ºC
Merck	14,7254
JECFA Number	1026
BRN	907949
Stabilität	Stable. Substances to be avoided include strong bases, strong oxidizing agents. Combustible.
InChIKey	LCPDWSOZIOUXRV-UHFFFAOYSA-N
LogP	1.34
CAS Datenbank	122-59-8(CAS DataBase Reference)
NIST chemische Informationen	Acetic acid, phenoxy-(122-59-8)
EPA chemische Informationen	Phenoxyacetic acid (122-59-8)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26-36-37/39
RIDADR	UN 3345 6.1/ PGIII
WGK Germany	3
RTECS-Nr.	AJ2230000
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29189090
Toxizität	LD50 orally in Rabbit: 1500 mg/kg LD50 dermal Rabbit > 5000 mg/kg

Gefahreninformationscode (GHS)

Phenoxyacetic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Phenoxyacetic acid has a sour, sweet odor and a honey-like taste.
Occurrence
Reported found in cocoa beans
Verwenden
Phenoxyacetic acid is a flavoring ingredient.?Its photodegradation using titanium dioxide as photocatalyst has been studied. Selective separation of penicillin V from phenoxyacetic acid using liquid membranes consisting of 1,2-dichloroethane and Amberlite LA-2 as carrier has been studied.
Verwenden
Fungicide; keratin exfoliative (to relieve and to soften calluses, corns, and other hard skin surfaces; applied as plasters, pads or in liquids).
Definition
ChEBI: Phenoxyacetic acid is a monocarboxylic acid that is the O-phenyl derivative of glycolic acid. A metabolite of 2-phenoxyethanol, it is used in the manufacture of pharmaceuticals, pesticides, fungicides and dyes. It has a role as a human xenobiotic metabolite, an Aspergillus metabolite, a plant growth retardant and an allergen. It is a monocarboxylic acid and an aromatic ether. It is functionally related to a glycolic acid. It is a conjugate acid of a phenoxyacetate.
Synthesis Reference(s)
Synthetic Communications, 16, p. 479, 1986 DOI: 10.1080/00397918608057726
Allgemeine Beschreibung
Light tan powder or white solid.
Air & Water Reaktionen
Slightly soluble in water.
Reaktivität anzeigen
Phenoxyacetic acid reacts exothermically with all bases, both organic (for example, the amines) and inorganic.
Health Hazard
ACUTE/CHRONIC HAZARDS: Phenoxyacetic acid is a mild skin irritant.
Brandgefahr
Flash point data for Phenoxyacetic acid are not available; however Phenoxyacetic acid is probably combustible.
Synthese
A Schlenk tube was charged with aryl iodides (1) (1.0 mmol), glycolic acid (228 mg, 3.0 mmol), CuI (19.0 mg, 0.1 mmol), Cs2CO3 (1.95 g, 6.0 mmol), and DMSO/H2O (2 mL/1 mL). The mixture was stirred for 24 h at 120 ℃ under Ar. The reaction mixture was allowed to cool to room temperature, poured into 5 mL of water, and then acidified to pH = 1 with 2 N HCl solution. The aqueous phase was extracted twice with EtOAc, and the combined organic layer was washed with H2O and brine, dried over anhydrous MgSO4, and concentrated under vacuum. Purification of the crude product by column chromatography (dichloromethane/methanol) afforded the desired product Phenoxyacetic acid, white solid, yield 133 mg, 88%.
läuterung methode
Crystallise the acid from water or aqueous EtOH. [Beilstein 6 IV 634.]

Phenoxyacetic acid Upstream-Materialien And Downstream Produkte

Phenoxyessigsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

122-59-8, Phenoxyacetic acid Verwandte Suche:

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