3-Iodobenzylaminhydrochlorid

Bezeichnung:3-Iodobenzylaminhydrochlorid

CAS-Nr3718-88-5

Englisch Name:3-Iodobenzylamine hydrochloride

CBNumberCB3324936

SummenformelC7H9ClIN

Molgewicht269.51

MOL-Datei3718-88-5.mol

Synonyma

3-Iodobenzylaminhydrochlorid

3-Iodobenzylaminhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	188-190 °C(lit.)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Wasserlöslichkeit	Soluble in water
Aggregatzustand	powder to crystal
Farbe	White to Light yellow
Sensitive	Light Sensitive
BRN	5352277
InChI	InChI=1S/C7H8IN.ClH/c8-7-3-1-2-6(4-7)5-9;/h1-4H,5,9H2;1H
InChIKey	PYFDZOCGFHIRST-UHFFFAOYSA-N
SMILES	C(C1C=CC=C(I)C=1)N.Cl
CAS Datenbank	3718-88-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,T,Xn
R-Sätze:	36/37/38-63-42/43
S-Sätze:	24/25-36/37/39-26-23-22
WGK Germany	3
Hazard Note	Irritant/Light Sensitive
HS Code	29214990
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Repr. 2 Resp. Sens. 1 Skin Irrit. 2 Skin Sens. 1 STOT SE 3

Gefahreninformationscode (GHS)

3-Iodobenzylamine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
Chemische Eigenschaften
white to light yellow crystal powde
Verwenden
3-Iodobenzylamine hydrochloride was used as the starting reagent in the synthesis of N⁶-(3-iodobenzyl)-2-substituted-adenosine derivatives. It was used in the synthesis of 3′-C-methyl adenosine N⁶-substituted and N⁶/C-2 disubstituted derivatives and novel 2′-C-methyl analogues.
Synthese

200706-60-1

3718-88-5

The general procedure for the synthesis of 3-iodobenzylamine hydrochloride from the compound (CAS: 200706-60-1) was as follows: 2.0 g (5.6 mmol) of compound (A) and 20 mL of anhydrous ethanol were added to the reaction flask. After heating the mixture to 60°C, an ethanolic solution of hydrazine hydrate (prepared by dissolving 0.42 g, 8.4 mmol of hydrazine hydrate in 3 mL of anhydrous ethanol) was added dropwise under continuous stirring. The reaction was kept heated and stirred for 20 min and a yellow precipitate was observed to be formed. Stirring was stopped and the reaction mixture was kept in a 70°C water bath for 2.5 hours. It was then cooled to room temperature, at which time a large amount of yellow precipitate precipitated. 4 mL of 1 mol/L hydrochloric acid solution was added to the reaction flask to acidify the reaction mixture and stirring was continued for 30 minutes. After completion of the reaction, a filtration operation was carried out, the filtrate was washed with a small amount of water and the filtrates were combined. The combined filtrates were evaporated to dryness under reduced pressure and finally dried under vacuum to give 0.539 g of yellow solid (B) in 35.9% yield.
Einzelnachweise
[1] Patent: CN106187823, 2016, A. Location in patent: Paragraph 0028; 0029

3-Iodobenzylamine hydrochloride Upstream-Materialien And Downstream Produkte

3-Iodobenzylaminhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

3718-88-5, 3-Iodobenzylamine hydrochloride Verwandte Suche:

Send Inquriy