Furan-2(5H)-on

Bezeichnung:Furan-2(5H)-on

CAS-Nr497-23-4

Englisch Name:2(5H)-Furanone

CBNumberCB3201475

SummenformelC4H4O2

Molgewicht84.07

MOL-Datei497-23-4.mol

Synonyma

Furan-2(5H)-on

Furan-2(5H)-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	4-5 °C (lit.)
Siedepunkt	86-87 °C/12 mmHg (lit.)
Dichte	1.185 g/mL at 25 °C (lit.)
FEMA	4138 \| 4-HYDROXY-2-BUTENOIC ACID GAMMA-LACTONE
Brechungsindex	n20/D 1.469(lit.)
Flammpunkt	214 °F
storage temp.	2-8°C
Löslichkeit	Chloroform, Ethyl Acetate (Slightly)
Aggregatzustand	Liquid
Farbe	Clear colorless to pale yellow or amber
Geruch (Odor)	buttery
Geruchsart	buttery
Wasserlöslichkeit	Immiscible with water.
JECFA Number	2000
BRN	383585
Henry's Law Constant	3.5×10^-1 mol/(m³Pa) at 25℃, Wang et al. (2017)
Stabilität	Moisture Sensitive
InChI	1S/C4H4O2/c5-4-2-1-3-6-4/h1-2H,3H2
InChIKey	VIHAEDVKXSOUAT-UHFFFAOYSA-N
SMILES	O=C1OCC=C1
LogP	-0.600
CAS Datenbank	497-23-4(CAS DataBase Reference)
NIST chemische Informationen	2(5H)-Furanone(497-23-4)
EPA chemische Informationen	2(5H)-Furanone (497-23-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26
WGK Germany	3
RTECS-Nr.	LU3453000
F	8-10
Hazard Note	Irritant
HS Code	29322980
Speicherklasse	10 - Combustible liquids
Giftige Stoffe Daten	497-23-4(Hazardous Substances Data)

Gefahreninformationscode (GHS)

2(5H)-Furanone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Colorless to pale brown-yellow clear liquid
Chemische Eigenschaften
2(5H)-Furanone is light brown liquid
Occurrence
Reported found in coffee
Verwenden
2(5H)-Furanone is employed in the preparation of 5-substituted 2(5H) furanones (gamma-butenolides) catalyzed by bifunctional aminothiourea and aminosquaramide organocatalysts through direct aldol reaction with aromatic aldehydes. Further, it is used in the synthesis of lignans by Michael addition reactions. In addition to this, it is used in three-component Michael-Aldol reactions with an aldehyde and thiolate or carbanion.
Verwenden
2(5H)-Furanone is a heterocyclic organic compound that is used widely in the synthetic preparation of pharmaceutical goods.
Verwenden
2(5H)-Furanone is a versatile reagent used in Michael addition reactions1 for synthesis of lignans.2 Also employed in three-component Michael-Aldol reactions with an aldehyde anda thiolate3 or carbanion.4
Definition
2(5H)-Furanone is a mycotoxin that contains an α,β-unsaturated lactone moiety.
Allgemeine Beschreibung
Chiral urea compounds catalyzed hetero-Michael addition reaction of 2(5H)-furanone (γ-crotonolactone) to pyrrolidine. The quorum sensing inhibition activity by 2(5H)-furanone was studied using bioindicator strains.
Hazard
Extremely toxic.
läuterung methode
Fractionally distil the lactone under reduced pressure. IR: (CCl4) 1784 and 1742 cm-1, UV no max above 205nm ( 1160 cm-1 M-1) and 1HR: (CCl3) : 2.15 (pair of triplets 1H), 3.85 (pair of triplets 1H) and 5.03 (triplet 2H). [Price & Judge Org Synth Coll Vol V 255 1973, Smith & Jones Can J Chem 37 2007, 2092 1959, Beilstein 17/9 V 112.]

2(5H)-Furanone Upstream-Materialien And Downstream Produkte

Furan-2(5H)-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

497-23-4, 2(5H)-Furanone Verwandte Suche:

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